Clindesse

Babesiosis, Mitral Valve Prolapse, Toxoplasmosis + 39 more

Treatment

19 Active Studies for Clindesse

What is Clindesse

Clindamycin

The Generic name of this drug

Treatment Summary

Clindamycin is a type of antibiotic that can be used to treat a range of bacterial infections. It is most effective against anaerobic bacteria, gram-positive cocci and bacilli, and gram-negative bacilli. It can also be used off-label to treat protozoal infections such as toxoplasmosis, malaria, and babesiosis. Clindamycin is a semi-synthetic form of lincomycin, a naturally occurring antibiotic discovered in soil samples from Lincoln, Nebraska. It is a more effective form of the drug, and it has largely replaced lincomycin in

Cleocin Hydrochloride

is the brand name

image of different drug pills on a surface

Clindesse Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cleocin Hydrochloride

Clindamycin

1970

507

Effectiveness

How Clindesse Affects Patients

Clindamycin is an antibiotic that stops the growth of bacteria. It needs to be taken every 6 hours to work properly. Clindamycin can cause severe diarrhea, especially in those who use it for a long time. It can also cause overgrowth of a dangerous bacteria, _Clostridium difficile_. Therefore, it should only be used to treat serious infections when other, less toxic drugs won't work. Clindamycin works against a variety of bacteria, including both gram-positive and gram-negative anaerobes. However, resistance to clindamycin can develop, so it's important to

How Clindesse works in the body

Clindamycin prevents bacteria from reproducing by stopping their proteins from being made. It does this by blocking the bacterial ribosome's ability to assemble and translate the proteins. Clindamycin's shape is similar to certain molecules in the bacteria, which helps it to interfere with their protein production. We don't know exactly how it helps to clear up acne, but it may have something to do with its ability to fight the bacteria that causes it.

When to interrupt dosage

The suggested measure of Clindesse is contingent upon the diagnosed disorder, including viridans group streptococci, Vaginal Infections and Surgical Intervention. The degree of dosage can be found in the following table, depending on the method of delivery (e.g. Cream - Vaginal or Suspension - Topical).

Condition

Dosage

Administration

viridans group streptococci

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Heart Valve Prosthesis

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Communicable Diseases

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Bacteria, Anaerobic

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Respiratory Tract Infections

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Malaria

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Bone and Bones

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Heart Defects, Congenital

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Acne Vulgaris

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

penicillins

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Hypertrophic Cardiomyopathy

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Surgical Intervention

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Bone and Bones

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Endometritis caused by Anaerobic Bacterial Infection

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

prophylaxis of Bacterial endocarditis

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Acne Vulgaris

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Endocarditis, Bacterial

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Candidiasis, Vulvovaginal

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Pneumonia, Pneumocystis

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Mixed Vaginal Infections

150.0 mg, 300.0 mg, , 0.02 mg/mg, 75.0 mg/mL, 150.0 mg/mL, 75.0 mg, 0.01 mg/mg, 10.0 mg/mL, 6.0 mg/mL, 12.0 mg/mL, 18.0 mg/mL, 100.0 mg/mL, 10.0 mg, 0.1 mg/mg, 100.0 mg, 1.0 %, 1.2 %, 30.0 mg/mL, 60.0 mg/mL, 90.0 mg/mL, 0.012 mg/mg, 11.9 mg/mL, 5.0 mg/mg, 0.007 mg/mg, 0.01 mg/mL

, Capsule - Oral, Oral, Capsule, Vaginal, Cream, Cream - Vaginal, Injection, solution, concentrate - Intravenous, Intravenous, Topical, Gel - Topical, Gel, Suspension, Suspension - Topical, Solution, Solution - Topical, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Swab - Topical, Swab, Kit, Kit - Topical, Aerosol, foam, Aerosol, foam - Topical, Lotion, Lotion - Topical, Granule, for solution - Oral, Granule, for solution, Capsule, gelatin coated - Oral, Kit - Intramuscular; Intravenous, Powder, for solution - Oral, Powder, for solution, Solution - Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Solution - Intravenous, Cream - Topical, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Suppository, Suppository - Vaginal, Capsule, gelatin coated, Liquid, Injection - Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Intramuscular; Intravenous, Gel - Vaginal, Injection, solution, concentrate - Intramuscular; Intravenous

Warnings

Clindesse has four contraindications. It should not be administered when dealing with any of the conditions shown in the following table.

Clindesse Contraindications

Condition

Risk Level

Notes

Enterocolitis, Pseudomembranous

Do Not Combine

Crohn Disease

Do Not Combine

Ulcerative Colitis

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Clindamycin may interact with Pulse Frequency

There are 20 known major drug interactions with Clindesse.

Common Clindesse Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Clindamycin.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Clindamycin.

Bromocriptine

Major

The serum concentration of Bromocriptine can be increased when it is combined with Clindamycin.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Clindamycin.

Cabergoline

Major

The serum concentration of Cabergoline can be increased when it is combined with Clindamycin.

Clindesse Toxicity & Overdose Risk

The most toxic dose of clindamycin in mice was 2540mg/kg and in rats it was 2190mg/kg. There have not been any reports of overdose yet, but symptoms could include abdominal pain, nausea, vomiting, and diarrhea. In clinical trials, one 3-year-old child was given a daily dose of 100mg/kg for 5 days and only had mild stomach pain and diarrhea. Activated charcoal can be used to help remove unabsorbed drug, but dialysis is not effective. General supportive care is recommended in cases of clindamycin overdose.

image of a doctor in a lab doing drug, clinical research

Clindesse Novel Uses: Which Conditions Have a Clinical Trial Featuring Clindesse?

73 active trials are being conducted to assess the potential of Clindesse in providing Bacterial Endocarditis, Acne and Pneumocystis Jirovecii Pneumonia relief.

Condition

Clinical Trials

Trial Phases

Respiratory Tract Infections (RTI) caused by susceptible streptococci

0 Actively Recruiting

Acne Vulgaris

3 Actively Recruiting

Phase 1, Phase 2, Early Phase 1, Phase 4

Mitral Valve Prolapse

1 Actively Recruiting

Not Applicable

Hypertrophic Cardiomyopathy

4 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Surgically constructed systemic-pulmonary shunt

0 Actively Recruiting

Respiratory Tract Infections

0 Actively Recruiting

Bacteria, Anaerobic

0 Actively Recruiting

Heart Defects, Congenital

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Bone and Bones

0 Actively Recruiting

Babesiosis

1 Actively Recruiting

Phase 2

Mixed Vaginal Infections

0 Actively Recruiting

Toxoplasmosis

1 Actively Recruiting

Phase 4

Surgical Intervention

0 Actively Recruiting

Pelvic cellulitis caused by Anaerobic Bacterial Infection

0 Actively Recruiting

Bacterial Endocarditis

0 Actively Recruiting

Malaria

0 Actively Recruiting

Acne Vulgaris

0 Actively Recruiting

Vaginal Infections

0 Actively Recruiting

Acquired Immunodeficiency Syndrome

5 Actively Recruiting

Phase 1, Phase 2, Not Applicable

Clindesse Reviews: What are patients saying about Clindesse?

5

Patient Review

12/17/2014

Clindesse for Vaginosis caused by Bacteria

Cleocin did not help with the burning or pain associated with my bacterial vaginosis and, in fact, made it much worse. It also caused nausea and stomach pains. I'm now trying boric acid suppositories at the recommendation of my doctor.

5

Patient Review

10/19/2022

Clindesse for Vaginosis caused by Bacteria

I didn't experience any of the negative side effects I read about before taking this medication. There was some light discharge for the first few days, but nothing a liner couldn't handle. All in all, this treatment was very successful and only cost me $125 with insurance.

5

Patient Review

4/22/2014

Clindesse for Vaginosis caused by Bacteria

I am using the vaginal insert, not the pill. How long until the odor is gone?

5

Patient Review

1/18/2016

Clindesse for Vaginosis caused by Bacteria

Worked very quickly and overnight as advertised. The horrible smell was gone by the morning, which is a huge relief. I usually get bacterial vaginosis (BV) constantly, and my doctor usually prescribes me Flagyl; however, that always makes me violently ill. With this product, I only had mild pelvic pain and white, clumpy discharge; but it's way better than explosive and painful diarrhea.

4.7

Patient Review

10/22/2015

Clindesse for Vaginosis caused by Bacteria

Though it may make sex feel quite uncomfortable, this medication really helped me clear up a tough bacterial infection. I had tried other prescribed medications to no avail, but Clindesse did the trick within just a day or so.

4.3

Patient Review

5/25/2018

Clindesse for Vaginosis caused by Bacteria

I'm on day six of this medication, and while it was easy enough to administer, the itching has been driving me up the wall. The discharge is still present, but there does seem to be a reduction in odor.

3.7

Patient Review

1/30/2009

Clindesse for Vaginosis caused by Bacteria

3.7

Patient Review

8/17/2011

Clindesse for Vaginosis caused by Bacteria

I had severe abdominal pain after taking this medication, to the point where I thought it might be from my period. However, even after my period ended, the pain persisted. This stuff is not worth it in my opinion.

2

Patient Review

8/7/2014

Clindesse for Vaginosis caused by Bacteria

This worked well for me.

2

Patient Review

4/4/2017

Clindesse for Vaginosis caused by Bacteria

Unfortunately, this medication didn't provide any relief for me. In fact, I think it made things worse.

1

Patient Review

10/27/2016

Clindesse for Vaginosis caused by Bacteria

I had been struggling with bacterial vaginosis for four years before I finally found Clindesse. This medication cleared up my symptoms in just a month and I haven't had any issues since!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clindesse

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Clindesse an antibiotic?

"Clindesse is a single-dose antibiotic cream used to treat bacterial vaginosis (vaginal infections caused by certain bacteria) in non-pregnant women. Clindesse Cream works by slowing the growth of these bacteria."

Answered by AI

Does Clindesse cause yeast infection?

"If these effects persist or worsen, stop using this product and consult your doctor or pharmacist.

Although mild stomach upset is uncommon, it may occur. If your symptoms persist or worsen, consult your doctor or pharmacist. You may have a new vaginal infection if you experience discomfort, burning, itching, or discharge. These symptoms may worsen while using this product. If your symptoms persist or worsen, stop using the product and consult your doctor or pharmacist."

Answered by AI

How long does Clindesse stay in the vagina?

"If you have sex while the mineral oil is still in your vagina, your condom or vaginal diaphragm could break.

The mineral oil in Clindesse (clindamycin) can make latex products like condoms and vaginal diaphragms weaker. It stays in your vagina for 5 days after you use it, so if you have sex during that time, your condom or vaginal diaphragm could break."

Answered by AI

What is Clindesse used for?

"This medication is used to treat bacterial vaginosis, a type of vaginal infection, in women who are not pregnant. Clindamycin, an antibiotic, works by stopping the growth of bacteria."

Answered by AI

Clinical Trials for Clindesse

Image of New Jersey Community Research Initiative in Newark, United States.

Treatment for HIV/AIDS

18+
All Sexes
Newark, NJ

One in four older persons living with HIV/AIDS (PLWHA) report at least one suicide attempt in their lifetime, and the risk for death by suicide is 100 times higher in PLWHA than in the general population. Currently, there are no behavioral interventions that specifically address suicide prevention for older PLWHA, despite their unique biopsychosocial and structural risk factors. Through this work, investigators will adapt Dialectical Behavior Therapy, an evidence-based intervention for suicide prevention, for patients with PLWHA to be delivered by an AI-powered conversational Agent developed by our industry partner, Empower Health. Investigators will then pilot test the feasibility, usability, acceptability and preliminary efficacy to improve self-efficacy to manage negative emotions in n=50 older adults living with HIV/AIDS.

Recruiting
Has No Placebo

New Jersey Community Research Initiative (+1 Sites)

Elissa Kozlov, PhD

Image of McGill university Health Centre (Royal victoria Hospital and Montreal General Hospital in Montreal, Canada.

Systemic Corticosteroids for Pneumocystis Pneumonia

18+
All Sexes
Montreal, Canada

The HOW LONG trial is an international, multicenter, Phase IV randomized clinical trial evaluating the optimal duration of adjunctive systemic corticosteroids in immunocompromised adults with severe Pneumocystis jirovecii pneumonia (PCP) who demonstrate early clinical recovery. Participants who no longer require supplemental oxygen by day 10 of corticosteroid therapy are randomized to discontinue corticosteroids at day 10 (or hospital discharge, if earlier) versus continue corticosteroids for a total of 21 days. The trial assesses whether earlier discontinuation reduces steroid-related complications while maintaining clinical outcomes.

Phase 4
Waitlist Available

McGill university Health Centre (Royal victoria Hospital and Montreal General Hospital

Image of Los Angeles General Medical Center in Los Angeles, United States.

Decision Support Tool for HIV Treatment

18+
All Sexes
Los Angeles, CA

This study is testing software designed to help healthcare providers choose the best HIV treatment combinations for their patients. HIV medicines, known as antiretroviral therapy (ART), can be complex to manage because the right regimen depends on many factors-such as drug resistance, other health conditions, and medication schedules. Many people with HIV are cared for by general clinicians who may not have access to HIV specialists, which can make treatment decisions more challenging. In this study, healthcare providers will use patient cases to compare standard HIV treatment resources with a new clinical decision support tool that gives evidence-based ART recommendations at the point of care. The investigators hypothesize that using the tool will help providers select treatment plans that better match clinical guidelines, make decisions faster, reduce mental effort, and increase overall satisfaction with the prescribing process.

Waitlist Available
Has No Placebo

Los Angeles General Medical Center

Hayoun Lee, PhD

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Image of Montefiore Medical Center in Bronx, United States.

myPACE+ Algorithm for Hypertrophic Cardiomyopathy

18+
All Sexes
Bronx, NY

This will be a two-arm investigator-initiated randomized controlled study of patients with nHCM and LV ejection fraction ≥50% and NYHA II-III symptoms, normal intrinsic conduction system and pre-existing suitable dual-chamber implantable cardioverter defibrillators (ICD) systems. Patients will be randomly assigned to either personalized accelerated pacing (using the myPACE+ algorithm with mono-fractional exponent) or usual care groups. At baseline and after 3 months of pacing all patients will undergo a CPET, echocardiogram, blood work for NT-proBNP levels and complete the KCCQ-OSS and HCMSQ, questionnaires. The investigator team hypothesizes that personalized accelerated pacing will be safe and improve symptoms and heart-failure related quality of life, physical activity, pVO2, biomarkers (i.e. NT-proBNP), diastolic parameters and cardiac structure.

Recruiting
Has No Placebo

Montefiore Medical Center (+1 Sites)

Sandhya Murthy, MD

Medtronic

Image of Texas Tech University Health Sciences Center in Lubbock, United States.

Amoxicillin Challenge for Penicillin Allergy

18 - 89
All Sexes
Lubbock, TX

The goal of this clinical trial is to learn about dosing when testing to see if a penicillin allergy label can be removed from adults that had been labeled as "penicillin-allergic" previously. The main question it aims to answer is: \- In penicillin-allergic patients that are at low risk of having an allergic reaction, is a one-dose oral challenge with amoxicillin (a penicillin-based antibiotic) as safe and effective as a two-dose oral challenge? Participants will, after being identified as having a low-risk penicillin allergy, be administered oral amoxicillin in a controlled setting and then monitored for an allergic reaction. Researchers will compare participants that took one dose of amoxicillin to participants that took two doses of amoxicillin (a small dose and then a larger dose) to see if either group was more likely to develop an allergic reaction.

Phase 3
Recruiting

Texas Tech University Health Sciences Center

James A Tarbox, MD

Image of Medical University of South Carolina in Charleston, United States.

Isotretinoin vs Tetracycline for Acne

Any Age
All Sexes
Charleston, SC

In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.

Phase < 1
Recruiting

Medical University of South Carolina

Alex Richmond, MD, MSCR

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Image of University of California - San Francisco in San Francisco, United States.

Exercise Program for Hypertrophic Cardiomyopathy

18 - 80
All Sexes
San Francisco, CA

The EXCITE-HCM study is a randomized, controlled, blinded clinical trial designed to evaluate the effect of moderate intensity exercise training versus usual physicial activity on the improvement of HCM-related symptoms and cardiac function. About 70 participants will be recruited and randomized on a 1:1 ratio to either moderate intensity training or usual physicial activity interventions. Patients will be followed during a period of 24 weeks and assesesments as physical examination, questionnaires, 12 lead ecg's, biomarker levels, echocardiogram, Cardiac Magnetic resonance, PET and CPET will be performed to evaluate their response to the intervention.

Recruiting
Has No Placebo

University of California - San Francisco

Theodore P Abraham, M.D

Image of Rush University Medical Center in Chicago, United States.

Menstrual Cups for Vaginal Infections

15 - 35
Female
Chicago, IL

HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV. The HIV and sexually transmitted infection (STI) epidemics overlap with broader reproductive health concerns. Menstrual hygiene management is a big problem in low- and middle-income countries and a lack of menstrual products negatively impacts women's work-life. This comes from cultural taboos, stigma, and discrimination, promoting secrecy around menstruation, high cost of menstrual products, use of traditional materials (e.g. rags, cotton wool, etc.) causing leakage and odor, and lack of water and safe hygiene facilities. Menstrual cups designed for use during sex may help women prevent Bacterial vaginosis (BV) and STIs through hygienic period practices, and may help them avoid bad practices in an attempt to maintain vaginal dryness. The goal of this interventional trial is to test the impact of menstrual cups on vaginal microbiome, BV, and STIs of poor women at high risk for STIs and HIV. We predict to see 25% less BV, our primary outcome, over one year. This trial aims to learn more about the safety of the intervention, and understand what is needed to fully implement the program.

Phase 2
Waitlist Available

Rush University Medical Center

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