Metrogel-Vaginal

Pouchitis, Liver Abscess, Amebic, Lung Abscess + 53 more

Treatment

41 FDA approvals

20 Active Studies for Metrogel-Vaginal

What is Metrogel-Vaginal

Metronidazole

The Generic name of this drug

Treatment Summary

Metronidazole is a prescription antibiotic used to treat various infections. It belongs to the nitroimidazole family of antibiotics and is effective in treating bacterial and parasitic infections, such as trichomoniasis, giardiasis, amebiasis, and gastrointestinal infections. Metronidazole is available as a pill, capsule, topical cream, and suppository. It has been used for decades to treat infections and continues to be an effective treatment option.

Flagyl

is the brand name

image of different drug pills on a surface

Metrogel-Vaginal Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Flagyl

Metronidazole

1963

449

Approved as Treatment by the FDA

Metronidazole, commonly known as Flagyl, is approved by the FDA for 41 uses including Abscess and Bone and Joint Infections .

Abscess

Bone and Joint Infections

Liver Abscess

Communicable Diseases

Osteomyelitis

Bacterial Endocarditis

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Bismuth subsalicylate

Abdominal Abscess

Abdominal Infection

Skin and skin structure infections

Gynaecological infection

Lung Abscess

Endometritis

Central Nervous System Bacterial Infections

Bacterial Meningitis

Pneumonia

intra-abdominal bacterial infections

hepatic abscess

Tubo-ovarian abscess

Lung Abscess

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Lower respiratory tract infection bacterial

Bacterial Septicemia

Bacteria, Anaerobic

Bacterial Infections

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Meningitis

Abscess, Intra-Abdominal

Empyema

asymptomatic Trichomoniasis

Exposure via partner

Endomyometritis

Bacterial Peritonitis

Central Nervous System Bacterial Infections

Empyema

Trichomonas Infections

Endometritis

Endometritis

Bacteria

Endocarditis, Bacterial

Communicable Diseases

Effectiveness

How Metrogel-Vaginal Affects Patients

Metronidazole is used to treat certain bacterial and parasitic infections, including amebiasis, trichomoniasis, and giardiasis. It is effective against most anaerobic bacteria, but not against facultative anaerobes or obligate aerobes. This is because it damages the DNA of the microbes it targets. It is important to be aware that taking metronidazole can cause convulsions and peripheral neuropathy, especially at higher doses. If these symptoms occur, the drug should be stopped immediately. Additionally, it has been found to be carcinogenic in mice and rats. The effects on humans

How Metrogel-Vaginal works in the body

Metronidazole works by entering cells and breaking down into toxic metabolites. These metabolites can damage the DNA of certain organisms, like anaerobic bacteria and protozoans. Metronidazole is only toxic to these organisms because of the difference in their electron transport systems. When the nitro group of metronidazole is reduced by ferredoxin or flavodoxin, it creates toxic metabolites that can damage the DNA of the target organisms.

When to interrupt dosage

The dose of Metrogel-Vaginal is contingent upon the determined condition, including Exposure via partner, Skin and Curling Ulcer. The measure likewise differs depending on the method of delivery (e.g. Capsule or Vaginal) featured in the table beneath.

Condition

Dosage

Administration

Bacterial Vaginosis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Bacterial Septicemia

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Bacterial Peritonitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Tubo-ovarian abscess

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Vaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Trichomonas Vaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

post-surgical vaginal cuff infection

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Inflammatory Papule

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Pouchitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Giardiasis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Vulvovaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Uterine Cervicitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Exposure via partner

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Communicable Diseases

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Candida albicans

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Bacterial Meningitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Sinusitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Endocarditis, Bacterial

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Operative Surgical Procedures

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Lockjaw

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Vaginal, Gel - Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Suppository - Rectal, Rectal, Injection - Intravenous, Kit, Kit - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Ointment, Ointment - Topical, Insert - Vaginal, Insert, Solution, Tablet, extended release - Oral, Tablet, extended release, Tablet, coated, Tablet, coated - Oral

Warnings

Metrogel-Vaginal has three contraindications and should not be utilized if you are experiencing any of the conditions in the following table.

Metrogel-Vaginal Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

Pregnancy Trimester, First

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

There are 20 known major drug interactions with Metrogel-Vaginal.

Common Metrogel-Vaginal Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Metronidazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Metronidazole.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Metronidazole.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Metronidazole.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Metronidazole.

Metrogel-Vaginal Toxicity & Overdose Risk

The toxic dose of metronidazole in rats is 5000mg/kg. Overdosing on metronidazole can cause symptoms like nerve damage, brain toxicity, seizures, an unpleasant reaction if combined with alcohol, dark urine, a bad taste in the mouth, nausea, stomach pain, and dizziness, as well as a decrease in white blood cells. If someone overdoses on this drug, activated charcoal can help remove it from the body and poison control centers should be contacted for additional guidance.

image of a doctor in a lab doing drug, clinical research

Metrogel-Vaginal Novel Uses: Which Conditions Have a Clinical Trial Featuring Metrogel-Vaginal?

179 active studies are examining the potential of Metrogel-Vaginal to mitigate Curling Ulcer, Periodontitis and Central Nervous System Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Lockjaw

0 Actively Recruiting

Uterine Cervical Erosion

0 Actively Recruiting

Gum Disease

3 Actively Recruiting

Phase 3, Not Applicable

Abdominal Infection

0 Actively Recruiting

Rosacea

0 Actively Recruiting

Balantidiasis

0 Actively Recruiting

Empyema

1 Actively Recruiting

Phase 4

Abdominal Abscess

2 Actively Recruiting

Phase 4, Phase 1, Phase 2

Bacteria

0 Actively Recruiting

Trichomonas Infections

0 Actively Recruiting

Vulvovaginitis

0 Actively Recruiting

Lung Abscess

0 Actively Recruiting

Pouchitis

5 Actively Recruiting

Phase 2, Phase 3, Early Phase 1, Phase 4

Atopic Dermatitis

12 Actively Recruiting

Phase 2, Phase 3, Phase 4, Not Applicable

Acne Vulgaris

0 Actively Recruiting

Operative Surgical Procedures

0 Actively Recruiting

Liver Abscess, Amebic

0 Actively Recruiting

Trichomonas Vaginitis

2 Actively Recruiting

Phase 2, Phase 4

Amebic colitis

0 Actively Recruiting

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Metrogel-Vaginal Reviews: What are patients saying about Metrogel-Vaginal?

5

Patient Review

10/5/2015

Metrogel-Vaginal for Vaginosis caused by Bacteria

I have BV because of the foul smell when I urinate. As much as I try avoiding to go to gyn, the only thing that takes care of this problem for me is this medicine. It works by the second day, but I take the full five day course 1x/day so it stays at bay for a while. The cottage cheese discharge while using the medicine is normal and I also experience light cramping after tbe third day til I am done with the medicine

5

Patient Review

7/29/2019

Metrogel-Vaginal for Vaginosis caused by Bacteria

I just completed a five-day treatment of this medication and I'm already feeling so much better. I experienced some cramping on day three, as well as the discharge that indicates the medication is working, but those were really the only side effects I noticed.

4.3

Patient Review

10/31/2018

Metrogel-Vaginal for Vaginosis caused by Bacteria

I experienced a lot of pain and cramping while using this treatment. I also had stomach issues and a lot of discharge. The burning sensations and pressure were also very unpleasant. Overall, I hope it worked but it was definitely not a pleasant experience.

4.3

Patient Review

10/25/2022

Metrogel-Vaginal for Vaginosis caused by Bacteria

Some people will complain about anything, but the gel is actually working if you're experiencing clumping of your vaginal discharge. I've had wine while using it with no negative consequences, and it takes away BV after just five days. If you want to be productive, get your male partners treated for BV while you're getting treated yourself.

4

Patient Review

2/4/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I was pleasantly surprised that there wasn't any discomfort when inserting the medication. It didn't leak out, even when I was standing up (although I used it before bed and tried to stay lying down). Currently on day 4, symptoms for BV are gone, now just worried about a possible yeast infection after reading the reviews! Eating lots of yogurt in the meantime. Very happy with this product!

3.7

Patient Review

6/27/2021

Metrogel-Vaginal for Vaginosis caused by Bacteria

I was prescribed this gel by my gyno to treat recurring bv. I used it once per week for six months as directed, but found that each time I did so, I would end up with a week of really heavy discharge afterwards. It was incredibly inconvenient and messy, so I stopped using it after the six months were up.

2.7

Patient Review

3/12/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I have now been using this gel for five days. I experience cramps every night, but they aren't too bad (a four out of ten on the pain scale). The white, wet discharge is really unpleasant though. I hope I don't get a yeast infection after I finish the treatment.

2.7

Patient Review

8/3/2016

Metrogel-Vaginal for Vaginosis caused by Bacteria

I got bacterial vaginosis for the first time post-menopause. My doctor prescribed this gel to use for five nights before bed. It's easy to insert and didn't cause too much leaking when I wake in night time to go to bathroom, but one month later I got BV again. The second time my doctor prescribed this for me again, but it caused inflammation of my internal vaginal tissues, so she told me to stop it after day three. Will not use again.

1

Patient Review

10/6/2019

Metrogel-Vaginal for Vaginosis caused by Bacteria

The cramps, anxiety, and depression I felt after taking this medication were absolutely unbearable. I ended up having to take a different medication (clindimyicin) and it worked much better.

1

Patient Review

6/21/2020

Metrogel-Vaginal for Vaginosis caused by Bacteria

I unfortunately had an allergic reaction in the form of urticaria.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metrogel-vaginal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Metrogel VAG gel used for?

"This drugs is used to treat bacterial infections in the vagina. It works by stopping the growth of the bacteria."

Answered by AI

How long does it take for Metrogel to work for BV?

"Cigna Health states that most BV treatments will get rid of symptoms within two to three days, but it is recommended that you finish the treatment for BV within seven days."

Answered by AI

What are the side effects of Metrogel?

"If you experience any negative effects after taking this medication, such as a burning feeling, skin irritation, dryness, redness, metallic taste, nausea, or headache, tell your doctor or pharmacist right away."

Answered by AI

How do I use Metrogel for BV?

"If you are an adult, insert one 500 milligram tablet high into your vagina once a day in the evening for 10 or 20 days. If you are a child, your doctor will determine how much of the medicine you should use and how often you should use it."

Answered by AI

Clinical Trials for Metrogel-Vaginal

Image of Seeding Labs INC in Austin, United States.

Tailored Recommendations for Infant Gut Microbiome

No minimum age - 3
All Sexes
Austin, TX

The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months delivered via Cesarean section. The study aims to determine whether these interventions can increase beneficial bacteria, decrease C-section-associated microbiome signatures, reduce opportunistic pathogens, and improve functional potential for HMO digestion and SCFA production. The study also seeks to assess whether improvements in microbiome composition are associated with a reduced prevalence of early atopic symptoms. Researchers will compare three groups: a full intervention arm that receives microbiome reports, coaching, personalized recommendations, and educational materials; a limited intervention arm that receives simplified reports and basic recommendations; and a control arm that receives no results until study completion. This design allows evaluation of both a comprehensive intervention and a more scalable, minimal-results model. Participants will: 1. Provide six microbiome stool samples over a 24-month period. 2. Provide additional small stool samples at two timepoints for exploratory metabolomic analysis. 3. Receive microbiome reports and guidance according to their assigned study arm. 4. Complete surveys on infant health history, symptoms, diet, and environmental exposures. 5. Participate in standardized eczema assessment(s) administered by a Nurse Practitioner and evaluated by a Pediatric Allergy Specialist if any symptoms are reported. This study seeks to demonstrate that targeted microbiome support can positively shift gut microbial development in C-section infants and may reduce risks linked to the early stages of the atopic march. Findings may inform scalable strategies for delivering microbiome-based support in early life and improve long-term health outcomes for this high-risk population.

Waitlist Available
Has No Placebo

Seeding Labs INC

Qian Yuan, MD

Seeding, Inc DBA Tiny Health

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17
All Sexes
Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4
Waitlist Available

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc

Have you considered Metrogel-Vaginal clinical trials?

We made a collection of clinical trials featuring Metrogel-Vaginal, we think they might fit your search criteria.
Go to Trials
Image of UNC Chapel Hill in Chapel Hill, United States.

Intrapleural Enzyme Therapy for Pleural Infection

18+
All Sexes
Chapel Hill, NC

The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections). These medications-tissue plasminogen activator (tPA) and deoxyribonuclease (DNase)-are placed through a chest tube into the space between the lung and the chest wall to help clear out the infection. The investigators are trying to learn: * Does using the medicine once a day work just as well as using it twice a day? * Are there any differences in outcomes between patients who get the medicine once a day versus twice a day? * Does more or less fluid remain in the chest (seen on a chest x-ray) depending on how often the medicine is given? Participants will: * Have an infection around their lung and will already be getting normal hospital care, including a chest tube to drain the infected fluid around their lung. * Be asked to give permission to join the study. * Be randomly chosen (like flipping a coin) to get the medications either once a day or twice a day through the chest tube.

Phase 4
Waitlist Available

UNC Chapel Hill

Jason Akulian, MD, MPH

Have you considered Metrogel-Vaginal clinical trials?

We made a collection of clinical trials featuring Metrogel-Vaginal, we think they might fit your search criteria.
Go to Trials
Image of Office of Dental Health, Department of Health and Senior Services in Jefferson City, United States.

Dental Care for Pneumonia Prevention

60 - 100
All Sexes
Jefferson City, MO

The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : * improved dental health * reduced risk of pneumonia * better glucose control for diabetic patients compared to the pre-project dental and general health evaluations of residents and the pre-project facility incidence of pneumonia. Dental infection control treatment includes treating gum infections, stopping or slowing decay with fluoride, and assisting residents with effective tooth brushing and denture cleaning daily. Previous studies indicate dental infections can be inhaled and cause pneumonia or make diabetes worse. A shortage of dentists has limited care for nursing home residents. This project will allow dental hygienists and specially trained dental assistants to treat nursing home residents using telehealth methods (computers, cameras, internet, and telephone) to talk and work with dentists in different locations.

Recruiting
Has No Placebo

Office of Dental Health, Department of Health and Senior Services

Have you considered Metrogel-Vaginal clinical trials?

We made a collection of clinical trials featuring Metrogel-Vaginal, we think they might fit your search criteria.
Go to Trials