Prostin E2
Uterus evacuation, Medically induced abortion, Cervix Uteri + 4 more
Treatment
0 Active Studies for Prostin E2
Treatment for
Uterus evacuation
What is Prostin E2
Dinoprostone
The Generic name of this drug
Treatment Summary
Dinoprostone is a hormone-like substance used to soften the cervix and induce labor. It is naturally found in the body and is also available as a prescription drug in the form of a vaginal suppository. Dinoprostone helps the cervix prepare for childbirth and can also have an effect on bone resorption.
Prostin E2
is the brand name
Prostin E2 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prostin E2
Dinoprostone
1978
5
Effectiveness
How Prostin E2 Affects Patients
Dinoprostone is similar to the hormone prostaglandin E2 (PGE2). It induces labor and delivery by causing the uterus to contract, and can be used to end a pregnancy. It can also cause the muscles of the digestive system to spasm, resulting in vomiting and/or diarrhea which is a common side effect of dinoprostone.
How Prostin E2 works in the body
Dinoprostone is used to induce labor by causing the uterus to contract. We don't know exactly how it works, but it is thought that it affects the calcium levels in the cell membranes and increases intracellular concentrations of a type of adenosine. Dinoprostone also causes the cervix to soften, efface, and dilate, possibly due to the enzyme collagenase which it releases.
When to interrupt dosage
The advocated measure of Prostin E2 is contingent upon the established condition, including Uterine dilation and evacuation, Cervix Uteri and Labour. The volume of dosage varies, as per the technique of delivery featured in the table underneath.
Condition
Dosage
Administration
Uterus evacuation
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Medically induced abortion
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Cervix Uteri
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Uterine dilation and evacuation
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Induction of Labour
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Gestational Trophoblastic Disease
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Labour
, 0.1 mg/mg, 10.0 mg, 0.5 mg, 20.0 mg, 0.0005 mg/mg, 0.5 mg/mL, 0.002 mg/mg, 0.001 mg/mg
Vaginal, , Insert - Vaginal, Insert, Insert, extended release - Vaginal, Insert, extended release, Gel - Endocervical, Gel, Endocervical, Gel - Vaginal, Oral, Suppository, Suppository - Vaginal, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Prostin E2.
Common Prostin E2 Drug Interactions
Drug Name
Risk Level
Description
Carbetocin
Major
The risk or severity of adverse effects can be increased when Dinoprostone is combined with Carbetocin.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Dinoprostone.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Dinoprostone.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Dinoprostone.
Dofetilide
Major
The serum concentration of Dofetilide can be increased when it is combined with Dinoprostone.
Prostin E2 Toxicity & Overdose Risk
The lowest toxic dose of this drug in mice has been found to be 750 mg/kg, and in rats it is 500 mg/kg.
Prostin E2 Novel Uses: Which Conditions Have a Clinical Trial Featuring Prostin E2?
Three ongoing trials are assessing the potential of Prostin E2 to provide treatment for Cervix Uteri, Medically-Induced Abortion and Uterine Dilation and Evacuation.
Condition
Clinical Trials
Trial Phases
Medically induced abortion
0 Actively Recruiting
Uterine dilation and evacuation
0 Actively Recruiting
Induction of Labour
0 Actively Recruiting
Gestational Trophoblastic Disease
0 Actively Recruiting
Labour
0 Actively Recruiting
Cervix Uteri
0 Actively Recruiting
Uterus evacuation
0 Actively Recruiting
Prostin E2 Reviews: What are patients saying about Prostin E2?
3.7
Patient Review
2/5/2009
Prostin E2 for Abortion
Patient Q&A Section about prostin e2
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is prostin E2 used for?
"This medication can be used to cause an abortion during the second to third trimesters of pregnancy. It can also be used to help vaginally remove any remaining material in the womb from a miscarriage or missed abortion."
Answered by AI
How does prostaglandin E2 work?
"PGE2 softens and Ripens the cervix by stimulating uterine contractions and also by directly acting on the collagenase present in the cervix. There are currently two formulations of PGE2 analog available for use in cervical ripening: Prepidil, a vaginal gel, and Cervidil, a vaginal insert."
Answered by AI
How do you use prostin E2 for abortion?
"The patient should insert a suppository containing 20 mg of dinoprostone high into the vagina, remaining in the supine position for ten minutes following insertion. additional intravaginal administration of each subsequent suppository should be at 3-to 5-hour intervals until abortion occurs."
Answered by AI
How fast does prostin work?
"If you don't start having contractions after 6 hours of taking prostin, you will be given another tablet or gel. It can take up to 24 hours for a controlled-release pessary to start working. If you don't have contractions after 24 hours, you could be given another dose."
Answered by AI