Prostin Vr Pediatric

Impotence, Aquaporin 2, Raynaud Disease
Treatment
20 Active Studies for Prostin Vr Pediatric

What is Prostin Vr Pediatric

AlprostadilThe Generic name of this drug
Treatment SummaryAlprostadil is a medication used to widen blood vessels and improve blood flow. In infants, this drug is used to treat life-threatening heart defects by keeping the ductus arteriosus open until surgery can be performed. In adults, it is used to treat erectile dysfunction caused by a variety of factors, including nerve damage, circulation problems and psychological issues.
Prostin Vr Pediatricis the brand name
image of different drug pills on a surface
Prostin Vr Pediatric Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prostin Vr Pediatric
Alprostadil
1981
28

Effectiveness

How Prostin Vr Pediatric Affects PatientsAlprostadil (prostaglandin E1) is a natural substance that helps relax the walls of blood vessels and increases blood flow. In adult males, this drug increases blood flow to the penis, making it harder. In infants, it increases blood flow in the lungs or body.
How Prostin Vr Pediatric works in the bodyAlprostadil works by causing the blood vessels to widen, either in the lungs or in the penis. In infants with heart conditions, it can increase oxygen supply in the body. In adults, administration of alprostadil through injection or suppository causes the penis to swell and become rigid due to increased arterial blood flow into the corpus cavernosum. This entraps blood and prevents venous outflow.

When to interrupt dosage

The advised dosage of Prostin Vr Pediatric is subject to the diagnosed affliction, including Impotence, Raynaud's Phenomenon and Aquaporin 2. The quantity of dosage shifts, in correlation with the administration process delineated in the accompanying table.
Condition
Dosage
Administration
Impotence
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Kit; Liquid; Powder, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Solution - Intra-arterial; Intravenous, Solution, Intra-arterial; Intravenous, Liquid - Intra-arterial; Intravenous, Liquid, Powder, for solution, Powder, for solution - Intracavernous, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution - Intravascular; Intravenous, Injection, solution, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intracavernous, Solution - Intravascular, Injection - Intravascular; Intravenous, Injection, Injection, solution, concentrate
Aquaporin 2
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Kit; Liquid; Powder, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Solution - Intra-arterial; Intravenous, Solution, Intra-arterial; Intravenous, Liquid - Intra-arterial; Intravenous, Liquid, Powder, for solution, Powder, for solution - Intracavernous, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution - Intravascular; Intravenous, Injection, solution, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intracavernous, Solution - Intravascular, Injection - Intravascular; Intravenous, Injection, Injection, solution, concentrate
Raynaud Disease
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 0.01 mg/mL, 0.02 mg/mL, 0.04 mg/mL, 0.0232 mg, 0.0119 mg, 0.0105 mg/mL, 0.0054 mg/mL, 0.5 mg/mL, 0.0205 mg/mL, 0.1 mg/mL, 0.0411 mg/mL, 0.2 mg/mL, 0.02 mg, 0.0033 mg/mg, 0.0022 mg/mg
, Urethral, Suppository, Suppository - Urethral, Intracavernous, Kit; Liquid; Powder, for solution, Kit; Liquid; Powder, for solution - Intracavernous, Solution - Intra-arterial; Intravenous, Solution, Intra-arterial; Intravenous, Liquid - Intra-arterial; Intravenous, Liquid, Powder, for solution, Powder, for solution - Intracavernous, Topical, Cream - Topical, Cream, Intravascular, Injection, solution, concentrate - Intravascular, Intravascular; Intravenous, Injection, solution - Intravascular; Intravenous, Injection, solution, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intracavernous, Solution - Intravascular, Injection - Intravascular; Intravenous, Injection, Injection, solution, concentrate

Warnings

Prostin Vr Pediatric has fourteen contraindications and should not be employed in concert with the conditions listed in the table below.Prostin Vr Pediatric Contraindications
Condition
Risk Level
Notes
predisposition to multiple myeloma
Do Not Combine
penis
Do Not Combine
Polycythemia
Do Not Combine
Thrombocytosis
Do Not Combine
predisposition to priapism
Do Not Combine
Disease
Do Not Combine
Coitus
Do Not Combine
penile implants
Do Not Combine
leukemia
Do Not Combine
Anemia, Sickle Cell
Do Not Combine
Pulse Frequency
Do Not Combine
Erectile Dysfunction
Do Not Combine
Hyperviscosity syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
There are 17 known major drug interactions with Prostin Vr Pediatric.
Common Prostin Vr Pediatric Drug Interactions
Drug Name
Risk Level
Description
Captopril
Minor
The excretion of Captopril can be decreased when combined with Alprostadil.
Cefdinir
Minor
The excretion of Cefdinir can be decreased when combined with Alprostadil.
Citrulline
Minor
The excretion of Citrulline can be decreased when combined with Alprostadil.
Cyclic adenosine monophosphate
Minor
The excretion of Cyclic adenosine monophosphate can be decreased when combined with Alprostadil.
Didanosine
Minor
The excretion of Didanosine can be decreased when combined with Alprostadil.
Prostin Vr Pediatric Toxicity & Overdose RiskThe lowest toxic dose of this drug in mice is 186mg/kg, and 228mg/kg in rats. Signs of overdose may include difficulty breathing, slow heartbeat, fever, low blood pressure, and flushed skin.
image of a doctor in a lab doing drug, clinical research

Prostin Vr Pediatric Novel Uses: Which Conditions Have a Clinical Trial Featuring Prostin Vr Pediatric?

27 active clinical trials are currently underway to explore the efficacy of Prostin Vr Pediatric in addressing Aquaporin 2 Deficiency, Erectile Dysfunction and Raynaud's Phenomenon.
Condition
Clinical Trials
Trial Phases
Aquaporin 2
3 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Raynaud Disease
1 Actively Recruiting
Phase 4
Impotence
17 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 1, Phase 2

Prostin Vr Pediatric Reviews: What are patients saying about Prostin Vr Pediatric?

5Patient Review
10/15/2010
Prostin Vr Pediatric for Pulmonary Atresia Present at Birth
This treatment saved my baby's life.

Patient Q&A Section about prostin vr pediatric

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is prostin calculated?

"The recommended starting dose of 0.1 micrograms per kilogram of body weight per minute is based on clinical studies; however, reports show that an adequate clinical response can be achieved using a starting dose of 0.05 micrograms per kilogram of body weight per minute."

Answered by AI

How do you inject prostin?

"Inject the medication into a different area on the opposite side of the penis from the site of the last dose each time. Apply pressure to the injection site with an alcohol swab for about 5 minutes after injection to prevent bruising. Do not use a bent needle to inject this medication."

Answered by AI

What is alprostadil used for in babies?

"This medicine is used to treat certain heart, lung, and blood vessel problems in infants. It helps to keep the ductus arteriosus (blood vessel in the heart) open temporarily before having a surgery. This medicine should only be given by or under the supervision of your child's doctor."

Answered by AI

What is prostin medication?

"Prostin E2 is a medication used to treat the symptoms associated with pregnancy termination. It may be used alone or in conjunction with other medications. Prostin E2 belongs to a class of drugs known as prostaglandins, vaginal preparations, and abortifacients."

Answered by AI

Clinical Trials for Prostin Vr Pediatric

Image of Wake Forest University Health Sciences in Winston-Salem, United States.

Exparel/Bupivacaine Mixture for Postoperative Pain in Erectile Dysfunction Surgery

18+
Male
Winston-Salem, NC
The inflatable penile prosthesis (IPP) is the gold standard for surgical management of erectile dysfunction (ED) and there is no consensus on the best postoperative pain management regimen. In the wake of the opioid epidemic, postoperative pain management is heavily scrutinized. The National Institute of Health estimated over 81,000 individuals died following overdose of any opioids in 2022 alone; of these, over 14,000 deaths were linked to prescription opioids. Thus, strategies to minimize postoperative pain should not only improve patient experience but also lessen the need to escalate to opioid usage.
Phase 4
Waitlist Available
Wake Forest University Health SciencesRyan Terlecki, MD
Image of McMaster Children's Hospital - Neonatal Intensive Care Unit in Hamilton, Canada.

Ibuprofen for Patent Ductus Arteriosus

< 18
All Sexes
Hamilton, Canada
Newborns born early are at risk for a serious health problem called patent ductus arteriosus (PDA). PDA is a passageway between heart and lung that can cause life-threatening complications such as bleeding in the brain or even death if it remains open and large. When closure of PDA is needed, doctors make every attempt to do it as soon as possible. Ibuprofen is the best drug to close the PDA, but it only works for 50% of small newborns. The investigators have shown before that small newborns handle ibuprofen differently and the amount of active ibuprofen that reaches their blood can be very unpredictable. Studies have shown if enough ibuprofen reaches the body, it can close the PDA. Therefore the investigators designed this study to see whether it is possible to give each newborn the right amount of ibuprofen that their body needs to close the PDA. The investigators will compare two ways to give ibuprofen in a small number of newborns: 1 - standard amount of ibuprofen to everyone, which is the usual care or 2 - ibuprofen doses that will be changed based on how much active ibuprofen has reached the body and how well the newborn's PDA is closing. The investigators will then compare the number of PDAs closed in each group and closely monitor any possible challenges for this new practice. By doing this project, the goals can be summarized as below: A. Primary goal: To determine if it is feasible to successfully run a larger study in the future. B. Secondary goals 1. To assess how well and how safely the personalized (MIPD) method works, using a tool called WAPPS-PDA to guide dosing. 2. To compare the effectiveness and safety of the personalized method with standard ibuprofen dosing. 3. To identify drug levels in the blood (Cmin, AUC0-24, AUC0-72) that are associated with complete, partial, or no response to treatment.
Phase 2
Recruiting
McMaster Children's Hospital - Neonatal Intensive Care UnitSamira Samiee-Zafarghandy, MD, FRCPC
Have you considered Prostin Vr Pediatric clinical trials? We made a collection of clinical trials featuring Prostin Vr Pediatric, we think they might fit your search criteria.Go to Trials
Image of Mount Sinai Hospital in New York, United States.

SAFE Technique for Erectile Dysfunction

18+
Male
New York, NY
Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the management of localized prostate cancer. However, post-prostatectomy erectile dysfunction (ED) and urinary incontinence still pose a challenge that adversely affects the patient's quality of life. Hydrodissection (HD) was introduced in 1987 in the medical field and it was tested for the first time during a retropubic radical prostatectomy back in 2005. Since then, research has indicated an improvement in erectile function results, presumably because of a less traumatic neural dissection and a decreased risk of neuropraxia. In an effort to achieve a balance between oncological excision and functional preservation, prostate surgery is evolving to incorporate intraoperative real-time evaluation of extracapsular extension. Recently, a micro-ultrasound operating at 29 MHz has been introduced. It provides a resolution down to 70 μ to assess the glandular pattern and cellular density of the prostatic tissue. Given the experience in more than a thousand cases with this technology, and the growing literature showing promising results in the detection and staging of prostate cancer; the researchers decided to implement this tool as guidance for hydrodissection of the layers of the lateral prostatic fascia. Robotic-Assisted Laparoscopic Prostatectomy and SAFE (Saline assisted fascial engorgement) nerve preservation guided by Microultrasound (MUS) is a prospective randomized controlled trial designed to evaluate the impact of normal saline solution hydrodissection (HD) on erectile function outcomes after RALP. This innovative approach consists of a transrectal ultrasound-guided HD using a high-resolution Microultrasound (MUS) (ExactVu micro-ultrasound, Exact Imaging, Markham, Canada). The technique will be applied to those patients who undergo grade 1, 2, or 3 NS approach taking into account the grading system proposed by Tewari et al. The hypothesis is that the SAFE technique could minimize the risk of a traumatic neurovascular bundle dissection while assessing the prostatic capsule integrity with a high-resolution MUS. The researchers also hypothesize that the use of SAFE along with RALP will optimize the post-surgery recovery of erectile function.
Phase 3
Recruiting
Mount Sinai HospitalAshutosh Kumar Tewari, MBBS, MCh, FRCS (Hon.)
Have you considered Prostin Vr Pediatric clinical trials? We made a collection of clinical trials featuring Prostin Vr Pediatric, we think they might fit your search criteria.Go to Trials
Have you considered Prostin Vr Pediatric clinical trials? We made a collection of clinical trials featuring Prostin Vr Pediatric, we think they might fit your search criteria.Go to Trials