Nexplanon

Contraceptive implant therapy, Birth Control, Reproductive Age + 1 more
Treatment
1 FDA approval
20 Active Studies for Nexplanon

What is Nexplanon

EtonogestrelThe Generic name of this drug
Treatment SummaryEtonogestrel is a hormone-based medication used for contraception. It is a type of progestin and was first developed by Merck's Organon subsidiary and approved by the FDA in 2001. The molecule is a synthetic, biologically active metabolite of desogestrel.
NuvaRingis the brand name
image of different drug pills on a surface
Nexplanon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
NuvaRing
Etonogestrel
2001
15

Approved as Treatment by the FDA

Etonogestrel, otherwise called NuvaRing, is approved by the FDA for 1 uses such as Contraceptive implant therapy .
Contraceptive implant therapy

Effectiveness

How Nexplanon Affects PatientsEtonogestrel is a contraceptive implant that works by preventing the release of the luteinizing hormone, which helps with ovulation. It also makes it harder for sperm to reach an egg, and prevents a fertilized egg from implanting in the uterus. In trials, it prevented 100% of pregnancies over three years, and normal periods returned for 91% of people within 90 days after the implant was removed. The implant releases 40 mcg of etonogestrel a day, and can last up to three years. The failure rate is very low, at 0.1%. Side effects include improved dysmenorrhea
How Nexplanon works in the bodyEtonogestrel connects to the progesterone and estrogen receptors in certain organs in the body like the female reproductive tract, mammary gland, hypothalamus, and pituitary. When connected, it alters the production of proteins, reducing the amount of gonadotropin-releasing hormone and luteinizing hormone.

When to interrupt dosage

The suggested dose of Nexplanon is contingent upon the diagnosed affliction, including Birth Control, Reproductive Age and Contraceptive implant therapy. The dosage also varies in accordance with the form of administration (e.g. Subcutaneous or Insert, extended release) specified in the table below.
Condition
Dosage
Administration
Contraceptive implant therapy
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
Insert, extended release - Vaginal, Vaginal, , Insert, extended release, Ring - Vaginal, Ring, Implant, Implant - Subcutaneous, Subcutaneous
Birth Control
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
Insert, extended release - Vaginal, Vaginal, , Insert, extended release, Ring - Vaginal, Ring, Implant, Implant - Subcutaneous, Subcutaneous
Reproductive Age
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
Insert, extended release - Vaginal, Vaginal, , Insert, extended release, Ring - Vaginal, Ring, Implant, Implant - Subcutaneous, Subcutaneous
Hormonal Contraception
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
Insert, extended release - Vaginal, Vaginal, , Insert, extended release, Ring - Vaginal, Ring, Implant, Implant - Subcutaneous, Subcutaneous

Warnings

Nexplanon Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Etonogestrel may interact with Pulse Frequency
Pulmonary Embolism
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Coronary Disease
Do Not Combine
Liver Failure, Acute
Do Not Combine
Hypersensitivity
Do Not Combine
Atrial Fibrillation
Do Not Combine
Metrorrhagia
Do Not Combine
Hereditary Angioedema Type III
Do Not Combine
diabetes mellitus with vascular disease
Do Not Combine
valvular thrombogenesis
Do Not Combine
Thrombosis
Do Not Combine
Smoking
Do Not Combine
Stroke
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Liver Neoplasms
Do Not Combine
Congenital hypercoagulation
Do Not Combine
Breast
Do Not Combine
Hypertensive disease
Do Not Combine
Liver Neoplasms
Do Not Combine
Hypersensitivity
Do Not Combine
Breast Cancer
Do Not Combine
Venous Thrombosis
Do Not Combine
Aphasia, Acquired
Do Not Combine
There are 20 known major drug interactions with Nexplanon.
Common Nexplanon Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Etonogestrel may increase the thrombogenic activities of Tranexamic acid.
Abacavir
Minor
Etonogestrel may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Etonogestrel.
Aclidinium
Minor
Etonogestrel may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Etonogestrel may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Nexplanon Toxicity & Overdose RiskThe toxic dose of etonogestrel for rats has been found to be higher than 2000mg/kg. Overdosing on etonogestrel only occurs when more than one implant is inserted, and in this case, removal of the implant is recommended. There is no evidence that etonogestrel causes cancer, genetic mutations, or affects fertility.
image of a doctor in a lab doing drug, clinical research

Nexplanon Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexplanon?

38 active studies are currently in progress to assess the potential of Nexplanon to provide Birth Control, Contraceptive implant therapy and Hormonal Contraception.
Condition
Clinical Trials
Trial Phases
Hormonal Contraception
0 Actively Recruiting
Reproductive Age
0 Actively Recruiting
Contraceptive implant therapy
0 Actively Recruiting
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2

Nexplanon Reviews: What are patients saying about Nexplanon?

5Patient Review
9/21/2022
Nexplanon for Birth Control
I've been extremely happy with my decision to get the Nexplanon implant. I had it for three years and just got the second one inserted. I lost my period for the first six months, but it went back to normal after that. I highly recommend this method to anyone considering it.
5Patient Review
9/27/2022
Nexplanon for Birth Control
This implant has been a life-changing experience. I no longer have to worry about my period or unwanted pregnancies for 3 years!
4.3Patient Review
10/20/2022
Nexplanon for Birth Control
The only problem is excessive bleeding. I bleed for months on end. I am highly emotional and angered easily since have the implant.
4Patient Review
8/21/2022
Nexplanon for Birth Control
My menstrual cycle was always irregular, but it became heavier and longer in the second and third years.
2.3Patient Review
9/28/2022
Nexplanon for Birth Control
I'm getting the implant removed in 13 days and I could not be more thrilled. For almost 10 months, I've had to endure heavy bleeding for 21-25 days out of the month with only a 10-14 day reprieve before it starts all over again. It's been awful – cramps, headaches, fatigue, depression, dryness when not bleeding. I can't wait to have this removed!
2.3Patient Review
9/12/2022
Nexplanon for Birth Control
I had a really tough time with this medication. I was constantly bleeding, cramping, and getting headaches. Definitely not worth it in my opinion.
2Patient Review
11/3/2022
Nexplanon for Birth Control
The onsertion was fine, but I started experiencing bruising and pain in my arm after a few days. This pain would come and go, but it became too much to bear after two months, so I had the treatment removed.
2Patient Review
8/23/2022
Nexplanon for Birth Control
I had the implant as i forget to take tablets. The 1st two months I had a period then no period for 4 months which was fantastic. For the last 9 months I had irregular periods that lasted from 2-6 weeks, low mood and severe cramps. It might work for you but it didn't work for me. Ensure you research the implant and consider the side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nexplanon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Nexplanon cause weight gain?

"Some people who use the birth control implant (AKA Nexplanon) may experience weight gain, but this is not a very common side effect and many people use the implant without issue."

Answered by AI

Can you get pregnant with Nexplanon?

"Nexplanon is one of the most effective birth control methods available, with a more than 99% rate of effectiveness. This means that pregnancy occurs in fewer than 1 out of 100 people who use Nexplanon in a year."

Answered by AI

What is Nexplanon and how does it work?

"The Nexplanon implant is a small, thin rod, about the size of a matchstick. The implant releases hormones into your body that prevent pregnancy. A nurse or doctor inserts the implant into your arm, protecting you from pregnancy for up to 5 years."

Answered by AI

What are the side effects of the Nexplanon?

"The side effects of this medication are: nausea, stomach cramping and bloating, dizziness, headache, breast tenderness, acne, hair loss, weight gain, and vaginal irritation and discharge. Additionally, pain, bruising, numbness, infection, and scarring can occur at the site where the rod is placed."

Answered by AI

Clinical Trials for Nexplanon

Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Image of EmpoweRx, Inc in Del Mar, United States.

HAPPI Software for Birth Control Access

18+
All Sexes
Del Mar, CA
The goal of this clinical trial is to learn if use of the HAPPI software can improve pharmacist-provided birth control services. The main questions it aims to answer are: 1. Does the HAPPI software make it easier for pharmacists to provide birth control services in their pharmacy? 2. Does the HAPPI software make it easier for patients to access birth control? Researchers will compare pharmacists' implementation and patients' access when using the HAPPI software and when not using the HAPPI software to see if the software improves implementation and access. Participants will include pharmacists and patients. Pharmacists will be asked to provide birth control services as normal while using the HAPPI software. Patients will be asked to receive birth control services from a pharmacist as normal, while using the HAPPI software.
Recruiting
Has No Placebo
EmpoweRx, Inc
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.Go to Trials
Image of Jackson State University/Department of Behavioral & Environmental Health in Jackson, United States.

PEN-3 Intervention for Postpartum Depression

18 - 45
Female
Jackson, MS
Maternal mortality in the United States is higher than in peer nations and has not decreased since 1990. Beyond mortality, severe maternal mortality impacts far too many women. Not only are these high rates alarming, but notable racial/ethnic and socioeconomic disparities exist. These inequities are highly regional, with women living in the rural southeast part of the United States, including the Mississippi Delta, having the highest rates of maternal mortality and morbidity. Unfortunately, these disparities have proven to be stubbornly resistant to interventions, necessitating an innovative multifaceted approach focused on community practice, building trust, and prioritizing patient voices. To meet this need, this proposal aims to establish the Mississippi Delta Research Center of Excellence for Maternal Health with the goal of addressing preventable maternal mortality, decreasing severe maternal morbidity, and promoting maternal health equity in partnership with the Mississippi Delta community. This patient-clinical linkages intervention study will evaluate the effectiveness of a multilevel and multisector communication and health literacy strategy to increase trust and engagement in postpartum healthcare among women in the Mississippi Delta, with a specific focus on Black women, their families, and their communities. These research projects both have the overarching goal of partnering with the community to determine and meet the needs of pregnant and postpartum women in the Mississippi Delta and address the disparities within maternity health and health care outcomes.
Recruiting
Has No Placebo
Jackson State University/Department of Behavioral & Environmental HealthMary Shaw, PhD
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Birth Control Pills and DNA Interaction

18 - 45
Female
Aurora, CO
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are: * Do individuals with the CYP3A7\*1C variant have increased metabolism of both desogestrel and ethinyl estradiol when taking a combined oral contraceptive pill? * Do individuals with the CYP3A7\*1C variant experience higher rates of breakthrough ovulation while taking a desogestrel/ethinyl estradiol combined oral contraceptive pill? * What novel genetic loci are associated with alterations in steroid hormone pharmacokinetics and pharmacodynamics among a larger cohort of combined oral contraceptive pill users? Participants will take a specific formulation of combined oral contraceptive pill (desogestrel/ethinyl estradiol) and undergo the following procedures: * Blood draw to measure the amount of progestin and estrogen in their system from the combined oral contraceptive pill * Questionnaires to assess side effects possibly caused by the combined oral contraceptive pill * Blood draw to measure endogenous hormone levels and biomarkers that may be affected by the combined oral contraceptive pill * A transvaginal ultrasound to measure any ovarian follicles (optional procedure)
Phase 4
Recruiting
University of Colorado Anschutz Medical Campus (+2 Sites)Aaron M Lazorwitz, MD, PhD
Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.Go to Trials
Image of Greater Boston Health Center in Boston, United States.

SBIRT for Alcohol and Substance Use Disorders

18+
All Sexes
Boston, MA
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance use behaviors while seeking care at a sexual and reproductive health (SRH) clinic. The main questions it aims to answer are: * Does SBIRT impact patients' alcohol and substance use, SRH, mental health, physical health, quality of life, and wellbeing? * Does SBIRT effectiveness differ by ethnicity, socioeconomic status, age, gender, and urbanicity? * Does SBIRT effectiveness differ by delivery mode (in-person vs. telemedicine)? Participants will receive in-person and telemedicine SBIRT, or usual care. Participants will complete surveys at interviews at baseline, 30 days, and 3 months. Researchers will compare patients who received SBIRT to patients who receive usual care to see if patients who receive the SBIRT intervention have a greater reduction in negative outcomes as compared to those who receive usual care. In this setting, usual care consists of basic quantity and frequency questions asked inconsistently as part of the admission process and varying by provider, with no standardized approach to screening, treatment, follow-up, or referral.
Recruiting
Has No Placebo
Greater Boston Health Center (+3 Sites)Kelli S Hall, MD
Image of OHSU in Portland, United States.

Progestin Contraceptives for Birth Control Effects

18 - 40
Female
Portland, OR
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Phase < 1
Recruiting
OHSUAlison Edelman, MD
Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.Go to Trials
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