Nexplanon

Contraceptive implant therapy, Birth Control, Reproductive Age + 1 more
Treatment
1 FDA approval
20 Active Studies for Nexplanon

What is Nexplanon

EtonogestrelThe Generic name of this drug
Treatment SummaryEtonogestrel is a hormone-based medication used for contraception. It is a type of progestin and was first developed by Merck's Organon subsidiary and approved by the FDA in 2001. The molecule is a synthetic, biologically active metabolite of desogestrel.
NuvaRingis the brand name
image of different drug pills on a surface
Nexplanon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
NuvaRing
Etonogestrel
2001
15

Approved as Treatment by the FDA

Etonogestrel, otherwise called NuvaRing, is approved by the FDA for 1 uses such as Contraceptive implant therapy .
Contraceptive implant therapy

Effectiveness

How Nexplanon Affects PatientsEtonogestrel is a contraceptive implant that works by preventing the release of the luteinizing hormone, which helps with ovulation. It also makes it harder for sperm to reach an egg, and prevents a fertilized egg from implanting in the uterus. In trials, it prevented 100% of pregnancies over three years, and normal periods returned for 91% of people within 90 days after the implant was removed. The implant releases 40 mcg of etonogestrel a day, and can last up to three years. The failure rate is very low, at 0.1%. Side effects include improved dysmenorrhea
How Nexplanon works in the bodyEtonogestrel connects to the progesterone and estrogen receptors in certain organs in the body like the female reproductive tract, mammary gland, hypothalamus, and pituitary. When connected, it alters the production of proteins, reducing the amount of gonadotropin-releasing hormone and luteinizing hormone.

When to interrupt dosage

The suggested dose of Nexplanon is contingent upon the diagnosed affliction, including Birth Control, Reproductive Age and Contraceptive implant therapy. The dosage also varies in accordance with the form of administration (e.g. Subcutaneous or Insert, extended release) specified in the table below.
Condition
Dosage
Administration
Hormonal Contraception
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
, Vaginal, Insert, extended release, Insert, extended release - Vaginal, Ring, Ring - Vaginal, Subcutaneous, Implant - Subcutaneous, Implant
Birth Control
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
, Vaginal, Insert, extended release, Insert, extended release - Vaginal, Ring, Ring - Vaginal, Subcutaneous, Implant - Subcutaneous, Implant
Reproductive Age
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
, Vaginal, Insert, extended release, Insert, extended release - Vaginal, Ring, Ring - Vaginal, Subcutaneous, Implant - Subcutaneous, Implant
Contraceptive implant therapy
11.7 mg, , 11.4 mg, 0.012 mg/hour, 68.0 mg
, Vaginal, Insert, extended release, Insert, extended release - Vaginal, Ring, Ring - Vaginal, Subcutaneous, Implant - Subcutaneous, Implant

Warnings

Nexplanon Contraindications
Condition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
acute liver disease
Do Not Combine
Hypersensitivity
Do Not Combine
thrombogenic rhythm
Do Not Combine
Metrorrhagia
Do Not Combine
Hereditary Angioedema Type III
Do Not Combine
diabetes mellitus with vascular disease
Do Not Combine
valvular thrombogenesis
Do Not Combine
Thrombosis
Do Not Combine
Smokers
Do Not Combine
Cerebrovascular Diseases
Do Not Combine
Pulmonary Embolism
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Congenital hypercoagulation
Do Not Combine
Breast
Do Not Combine
Hypertensive disease
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Hypersensitivity
Do Not Combine
Breast Cancer
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etonogestrel may interact with Pulse Frequency
history of deep venous thrombosis
Do Not Combine
Aphasia, Acquired
Do Not Combine
There are 20 known major drug interactions with Nexplanon.
Common Nexplanon Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Etonogestrel may increase the thrombogenic activities of Tranexamic acid.
Abacavir
Minor
Etonogestrel may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Etonogestrel.
Aclidinium
Minor
Etonogestrel may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Etonogestrel may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Nexplanon Toxicity & Overdose RiskThe toxic dose of etonogestrel for rats has been found to be higher than 2000mg/kg. Overdosing on etonogestrel only occurs when more than one implant is inserted, and in this case, removal of the implant is recommended. There is no evidence that etonogestrel causes cancer, genetic mutations, or affects fertility.
image of a doctor in a lab doing drug, clinical research

Nexplanon Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexplanon?

38 active studies are currently in progress to assess the potential of Nexplanon to provide Birth Control, Contraceptive implant therapy and Hormonal Contraception.
Condition
Clinical Trials
Trial Phases
Reproductive Age
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Contraceptive implant therapy
0 Actively Recruiting
Birth Control
32 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Early Phase 1

Nexplanon Reviews: What are patients saying about Nexplanon?

5Patient Review
9/21/2022
Nexplanon for Birth Control
I've been extremely happy with my decision to get the Nexplanon implant. I had it for three years and just got the second one inserted. I lost my period for the first six months, but it went back to normal after that. I highly recommend this method to anyone considering it.
5Patient Review
9/27/2022
Nexplanon for Birth Control
This implant has been a life-changing experience. I no longer have to worry about my period or unwanted pregnancies for 3 years!
4.3Patient Review
10/20/2022
Nexplanon for Birth Control
The only problem is excessive bleeding. I bleed for months on end. I am highly emotional and angered easily since have the implant.
4Patient Review
8/21/2022
Nexplanon for Birth Control
My menstrual cycle was always irregular, but it became heavier and longer in the second and third years.
2.3Patient Review
9/28/2022
Nexplanon for Birth Control
I'm getting the implant removed in 13 days and I could not be more thrilled. For almost 10 months, I've had to endure heavy bleeding for 21-25 days out of the month with only a 10-14 day reprieve before it starts all over again. It's been awful – cramps, headaches, fatigue, depression, dryness when not bleeding. I can't wait to have this removed!
2.3Patient Review
9/12/2022
Nexplanon for Birth Control
I had a really tough time with this medication. I was constantly bleeding, cramping, and getting headaches. Definitely not worth it in my opinion.
2Patient Review
11/3/2022
Nexplanon for Birth Control
The onsertion was fine, but I started experiencing bruising and pain in my arm after a few days. This pain would come and go, but it became too much to bear after two months, so I had the treatment removed.
2Patient Review
8/23/2022
Nexplanon for Birth Control
I had the implant as i forget to take tablets. The 1st two months I had a period then no period for 4 months which was fantastic. For the last 9 months I had irregular periods that lasted from 2-6 weeks, low mood and severe cramps. It might work for you but it didn't work for me. Ensure you research the implant and consider the side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nexplanon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Nexplanon cause weight gain?

"Some people who use the birth control implant (AKA Nexplanon) may experience weight gain, but this is not a very common side effect and many people use the implant without issue."

Answered by AI

Can you get pregnant with Nexplanon?

"Nexplanon is one of the most effective birth control methods available, with a more than 99% rate of effectiveness. This means that pregnancy occurs in fewer than 1 out of 100 people who use Nexplanon in a year."

Answered by AI

What is Nexplanon and how does it work?

"The Nexplanon implant is a small, thin rod, about the size of a matchstick. The implant releases hormones into your body that prevent pregnancy. A nurse or doctor inserts the implant into your arm, protecting you from pregnancy for up to 5 years."

Answered by AI

What are the side effects of the Nexplanon?

"The side effects of this medication are: nausea, stomach cramping and bloating, dizziness, headache, breast tenderness, acne, hair loss, weight gain, and vaginal irritation and discharge. Additionally, pain, bruising, numbness, infection, and scarring can occur at the site where the rod is placed."

Answered by AI

Clinical Trials for Nexplanon

Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.
Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.
Have you considered Nexplanon clinical trials? We made a collection of clinical trials featuring Nexplanon, we think they might fit your search criteria.