Norgestimate And Ethinyl Estradiol

Acne Vulgaris, moderate Vulvovaginal atrophy, Hot flashes + 9 more
Treatment
9 FDA approvals
20 Active Studies for Norgestimate And Ethinyl Estradiol

What is Norgestimate And Ethinyl Estradiol

NorgestimateThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the female hormone estrogen used in many oral contraceptive pills. It was first developed in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering, and was approved by the FDA in 1943. It is more effective than other forms of estrogen due to its higher oral bioavailability, meaning that it can be taken in pill form instead of being injected.
Ortho Tri Cyclenis the brand name
image of different drug pills on a surface
Norgestimate And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113

Approved as Treatment by the FDA

Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 9 uses which include Postmenopausal Osteoporosis and severe menopausal vulvovaginal atrophy .
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol

Effectiveness

How Norgestimate And Ethinyl Estradiol Affects PatientsEthinylestradiol is a man-made form of estrogen that is taken once daily. It works by reducing the hormones that cause ovulation and endometrial vascularization. It is considered to be a safe drug, but there is a risk of blood clots associated with it, so individuals taking it should be aware of the potential risks.
How Norgestimate And Ethinyl Estradiol works in the bodyEthinylestradiol is a synthetic form of the hormone estrogen. It works by preventing ovulation and making it harder for sperm to reach the uterus. It also reduces luteinizing hormone and increases sex hormone binding globulin, which reduces the amount of estrogen in the body. This can lead to decreased bone density.

When to interrupt dosage

The advocated measure of Norgestimate and Ethinyl Estradiol is contingent upon the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The quantity of dosage fluctuates, in accordance with the technique of delivery indicated in the accompanying table.
Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Osteoporosis, Postmenopausal
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Menorrhagia
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Dysmenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral

Warnings

Norgestimate And Ethinyl Estradiol Contraindications
Condition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Liver Neoplasms
Do Not Combine
There are 20 known major drug interactions with Norgestimate And Ethinyl Estradiol.
Common Norgestimate And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Norgestimate And Ethinyl Estradiol Toxicity & Overdose RiskWomen who overdose on this medication may suffer from bleeding, nausea, vomiting, breast pain, abdominal pain, drowsiness, and fatigue. Treatment should include supportive care such as monitoring for potassium and sodium levels, as well as signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Norgestimate And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norgestimate And Ethinyl Estradiol?

38 active clinical studies are exploring the potential of Norgestimate and Ethinyl Estradiol in providing Folate supplementation therapy, relieving Premenstrual Dysphoric Disorder and treating Menopause.
Condition
Clinical Trials
Trial Phases
Dysmenorrhea
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Oral Contraceptives
0 Actively Recruiting
Menopause
0 Actively Recruiting
Polycystic Ovarian Syndrome
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Hot flashes
16 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting

Norgestimate And Ethinyl Estradiol Reviews: What are patients saying about Norgestimate And Ethinyl Estradiol?

5Patient Review
7/12/2016
Norgestimate And Ethinyl Estradiol for Acne
I'm really happy with this birth control. I started using it when I was 23 and had never dealt with acne before, but then I suddenly got it really bad. After just five months of use, my face cleared up and has stayed that way ever since.
5Patient Review
4/6/2017
Norgestimate And Ethinyl Estradiol for Birth Control
I had extremely negative experiences with my last birth control pill in terms of mental health, so I was really relieved to find that this one didn't have the same issue! It's also been great in clearing up my acne and making my periods shorter. The only downside is that I experienced some spotting when I first started taking them, but that's par for the course with any BC pill. All things considered, I'm very happy with this form of contraception.
5Patient Review
12/4/2016
Norgestimate And Ethinyl Estradiol for Birth Control
It took me a long time to find the right birth control, but this one has really worked well for me. I would urge other women who are struggling to find something that works for them to keep trying different options and not give up hope.
5Patient Review
2/24/2022
Norgestimate And Ethinyl Estradiol for Abnormal Bleeding from the Uterus
I have found that this treatment provides me with energy and no negative side effects like headaches or cramps.
4.3Patient Review
3/8/2018
Norgestimate And Ethinyl Estradiol for Birth Control
I've been using this birth control for a little over a year and it's been effective. However, one downside is that it's caused me to break out on my face occasionally and also has resulted in melasma.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about norgestimate and ethinyl estradiol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is norgestimate and ethinyl estradiol a good birth control?

"Norgestimate and ethinyl estradiol birth control pills have a high success rate of over 99 percent when used correctly, and are still 91 percent effective in everyday use."

Answered by AI

What is the side effects of norgestimate ethinyl estradiol?

"The following side effects may occur: nausea, vomiting, headache, bloating, breast tenderness, swelling of ankles/feet (fluid retention), or weight change. Spotting (vaginal bleeding between periods) or missed/irregular periods may occur, especially during the first few months of use."

Answered by AI

What kind of birth control is norgestimate and ethinyl estradiol?

"This medication prevents ovulation and pregnancy by combining the hormones estrogen and progestin. It may also be used to treat acne."

Answered by AI

Do you get a period on norgestimate?

"As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional.

When you first start using this contraception method, you may experience vaginal bleeding of various amounts between your regular menstrual periods. This is sometimes called spotting when it is light, or breakthrough bleeding when it is heavier. If this should occur, continue with your regular dosing schedule. As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional."

Answered by AI

Clinical Trials for Norgestimate And Ethinyl Estradiol

Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.
Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.
Image of University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory in Aurora, United States.

MitoQ + Exercise for Menopause-Related Vascular Health

50 - 120
Female
Aurora, CO
This trial tests whether combining moderate aerobic exercise with the antioxidant MitoQ can improve blood vessel function in postmenopausal women who lack estrogen. MitoQ aims to reduce oxidative stress and enhance blood flow by improving mitochondrial function. The study will compare the effects of exercise with MitoQ, exercise alone, and MitoQ alone. MitoQ is a mitochondria-targeted antioxidant that has been studied for its potential to enhance exercise-induced muscle adaptations and improve peak power in untrained middle-aged men.
Phase < 1
Waitlist Available
Paid Trial
University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research LaboratoryKerrie L Moreau, PhD
Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.
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