Norgestimate And Ethinyl Estradiol

Acne Vulgaris, moderate Vulvovaginal atrophy, Hot flashes + 9 more
Treatment
9 FDA approvals
20 Active Studies for Norgestimate And Ethinyl Estradiol

What is Norgestimate And Ethinyl Estradiol

NorgestimateThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the female hormone estrogen used in many oral contraceptive pills. It was first developed in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering, and was approved by the FDA in 1943. It is more effective than other forms of estrogen due to its higher oral bioavailability, meaning that it can be taken in pill form instead of being injected.
Ortho Tri Cyclenis the brand name
image of different drug pills on a surface
Norgestimate And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Tri Cyclen
Norgestimate
1989
113

Approved as Treatment by the FDA

Norgestimate, commonly known as Ortho Tri Cyclen, is approved by the FDA for 9 uses which include Postmenopausal Osteoporosis and severe menopausal vulvovaginal atrophy .
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
severe menopausal vulvovaginal atrophy
Used to treat severe menopausal vulvovaginal atrophy in combination with Estradiol
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Ethinylestradiol
Acne Vulgaris
Used to treat moderate Acne vulgaris in combination with Ethinylestradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
moderate Vulvovaginal atrophy
Used to treat moderate Vulvovaginal atrophy in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol

Effectiveness

How Norgestimate And Ethinyl Estradiol Affects PatientsEthinylestradiol is a man-made form of estrogen that is taken once daily. It works by reducing the hormones that cause ovulation and endometrial vascularization. It is considered to be a safe drug, but there is a risk of blood clots associated with it, so individuals taking it should be aware of the potential risks.
How Norgestimate And Ethinyl Estradiol works in the bodyEthinylestradiol is a synthetic form of the hormone estrogen. It works by preventing ovulation and making it harder for sperm to reach the uterus. It also reduces luteinizing hormone and increases sex hormone binding globulin, which reduces the amount of estrogen in the body. This can lead to decreased bone density.

When to interrupt dosage

The advocated measure of Norgestimate and Ethinyl Estradiol is contingent upon the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The quantity of dosage fluctuates, in accordance with the technique of delivery indicated in the accompanying table.
Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
moderate Vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
severe menopausal vulvovaginal atrophy
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Menopause
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Osteoporosis, Postmenopausal
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Oral Contraceptives
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Menorrhagia
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Hirsutism
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
moderate Menopausal Vasomotor Symptoms
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Hot flashes
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Acne Vulgaris
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral
Dysmenorrhea
, 0.25 mg, 0.215 mg, 0.18 mg, 0.09 mg, 0.645 mg
Kit, , Oral, Tablet, Kit - Oral, Tablet - Oral

Warnings

Norgestimate And Ethinyl Estradiol Contraindications
Condition
Risk Level
Notes
Breast
Do Not Combine
Breast Cancer
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Metrorrhagia
Do Not Combine
Liver Neoplasms
Do Not Combine
There are 20 known major drug interactions with Norgestimate And Ethinyl Estradiol.
Common Norgestimate And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Norgestimate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Norgestimate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Norgestimate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Norgestimate.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Norgestimate.
Norgestimate And Ethinyl Estradiol Toxicity & Overdose RiskWomen who overdose on this medication may suffer from bleeding, nausea, vomiting, breast pain, abdominal pain, drowsiness, and fatigue. Treatment should include supportive care such as monitoring for potassium and sodium levels, as well as signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Norgestimate And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norgestimate And Ethinyl Estradiol?

38 active clinical studies are exploring the potential of Norgestimate and Ethinyl Estradiol in providing Folate supplementation therapy, relieving Premenstrual Dysphoric Disorder and treating Menopause.
Condition
Clinical Trials
Trial Phases
Dysmenorrhea
1 Actively Recruiting
Not Applicable
Acne Vulgaris
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Oral Contraceptives
1 Actively Recruiting
Not Applicable
Menopause
0 Actively Recruiting
Polycystic Ovarian Syndrome
6 Actively Recruiting
Not Applicable, Phase 1
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Hirsutism
0 Actively Recruiting
Hot flashes
19 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3
moderate Vulvovaginal atrophy
0 Actively Recruiting
Menorrhagia
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
severe menopausal vulvovaginal atrophy
0 Actively Recruiting

Norgestimate And Ethinyl Estradiol Reviews: What are patients saying about Norgestimate And Ethinyl Estradiol?

5Patient Review
7/12/2016
Norgestimate And Ethinyl Estradiol for Acne
I'm really happy with this birth control. I started using it when I was 23 and had never dealt with acne before, but then I suddenly got it really bad. After just five months of use, my face cleared up and has stayed that way ever since.
5Patient Review
4/6/2017
Norgestimate And Ethinyl Estradiol for Birth Control
I had extremely negative experiences with my last birth control pill in terms of mental health, so I was really relieved to find that this one didn't have the same issue! It's also been great in clearing up my acne and making my periods shorter. The only downside is that I experienced some spotting when I first started taking them, but that's par for the course with any BC pill. All things considered, I'm very happy with this form of contraception.
5Patient Review
12/4/2016
Norgestimate And Ethinyl Estradiol for Birth Control
It took me a long time to find the right birth control, but this one has really worked well for me. I would urge other women who are struggling to find something that works for them to keep trying different options and not give up hope.
5Patient Review
2/24/2022
Norgestimate And Ethinyl Estradiol for Abnormal Bleeding from the Uterus
I have found that this treatment provides me with energy and no negative side effects like headaches or cramps.
4.3Patient Review
3/8/2018
Norgestimate And Ethinyl Estradiol for Birth Control
I've been using this birth control for a little over a year and it's been effective. However, one downside is that it's caused me to break out on my face occasionally and also has resulted in melasma.
3.7Patient Review
1/24/2018
Norgestimate And Ethinyl Estradiol for Birth Control
I had such bad cystic acne after Nexplanon that my doctor recommended I try Starylla. Unfortunately, this didn't work out too well for me. After just two days of taking the pills (as directed, before bed), I woke up in the middle of the night with nausea and ended up vomiting both nights. I also had a headache and felt dizzy all day long.
2.7Patient Review
3/17/2021
Norgestimate And Ethinyl Estradiol for Abnormally Long or Heavy Periods
I started using this treatment last month and have had really heavy periods with bad cramps. It's like I'm not even on birth control! I'll try for the next two months and see if there are any changes, but I'm worried about the possible side effect of blood clots.
2Patient Review
5/3/2016
Norgestimate And Ethinyl Estradiol for Premenstrual Disorder with a State of Unhappiness
It's been three months and I've been taking BC to treat my PMS symptoms. The first month was really tough with nausea and vomiting, but that has passed. Now I'm just dealing with some weight gain, acne, and bleeding between periods. I'm hoping everything will be alright after the third month.
2Patient Review
6/4/2017
Norgestimate And Ethinyl Estradiol for Birth Control
I started taking this medication a few months ago and have already experienced some bad side effects. For example, I've had a continuous period for three weeks now, with no break in between cycles. Additionally, I often feel nauseous and have been getting blurred vision and migraines more frequently. I never had such problems when taking Ortho Tri Cyclen.
1.7Patient Review
1/22/2019
Norgestimate And Ethinyl Estradiol for Abnormally Long or Heavy Periods
I started this medication in order to help with my periods and cysts, but it's only made things worse. I've been moody, crying, vomiting, and in the second month of taking it I started a period that hasn't gone away yet. And on top of all that, I had a yeast infection the first month. They say you should give it three months to work, but I'm already miserable.
1.7Patient Review
12/3/2018
Norgestimate And Ethinyl Estradiol for Birth Control
I am a healthy 25 year old and began taking the pill again after giving my body a break from birth control. I am experiencing extremely bad mood swings very often and crying more than I ever have before. This definitely is not like me and I am going to stop taking this immediately.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about norgestimate and ethinyl estradiol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is norgestimate and ethinyl estradiol a good birth control?

"Norgestimate and ethinyl estradiol birth control pills have a high success rate of over 99 percent when used correctly, and are still 91 percent effective in everyday use."

Answered by AI

What is the side effects of norgestimate ethinyl estradiol?

"The following side effects may occur: nausea, vomiting, headache, bloating, breast tenderness, swelling of ankles/feet (fluid retention), or weight change. Spotting (vaginal bleeding between periods) or missed/irregular periods may occur, especially during the first few months of use."

Answered by AI

What kind of birth control is norgestimate and ethinyl estradiol?

"This medication prevents ovulation and pregnancy by combining the hormones estrogen and progestin. It may also be used to treat acne."

Answered by AI

Do you get a period on norgestimate?

"As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional.

When you first start using this contraception method, you may experience vaginal bleeding of various amounts between your regular menstrual periods. This is sometimes called spotting when it is light, or breakthrough bleeding when it is heavier. If this should occur, continue with your regular dosing schedule. As your body adjusts to this method of contraception, the bleeding should become less and eventually stop. If breakthrough bleeding continues off-and-on for more than 1 week or occurs after your period, call your healthcare professional."

Answered by AI

Clinical Trials for Norgestimate And Ethinyl Estradiol

Image of Goldring Center for High Performance Sport in Toronto, Canada.

Menstrual Cycle vs. Birth Control Pills for Protein Metabolism

18 - 40
Female
Toronto, Canada
The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover. Protein turnover is essential for maintaining healthy muscle. Despite its importance, females have historically been underrepresented in protein metabolism research. A long-standing assumption has been that fluctuations in female sex hormones such as estrogen and progesterone, whether across the natural menstrual cycle or in individuals using oral contraceptives (OCs), make metabolism and training responses too variable to study. Because of this, many researchers have excluded female participants for logistical reasons. Resistance exercise, such as weightlifting, is the most effective way to increase muscle size and strength. Each resistance-training session triggers muscle protein synthesis (MPS), the process by which new muscle proteins are built. Consuming dietary protein or individual amino acids further increases the rate at which new proteins are formed. Over time, higher rates of protein synthesis support muscle growth and the maintenance of other lean tissues in the body. The purpose of this study is to examine how menstrual cycle phases and OC use influence the synthesis of proteins in both muscle tissue and the rest of the body. Improving scientific understanding in this area will support more effective, evidence-based training and nutrition recommendations for females.
Recruiting
Has No Placebo
Goldring Center for High Performance Sport
Image of Erevna Innovations Inc. in Montreal, Canada.

Sculptra + Restylane for Post-Menopausal Skin Concerns

40 - 65
Female
Montreal, Canada
The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity. To address these concerns, aesthetic injectables products such as Sculptra® Aesthetic (poly-L-lactic-acid \[PLLA- SCA\]) and Restylane Skinboosters®\[HASBV\] (small-particle hyaluronic acid - SP-HA) can be used. PLLA-SCA stimulates collagen production via cellular activation (biostimulator), gradually improving dermal structure. HASBV enhances hydration, elasticity, and skin texture when injected under the skin. Considering that hydration and laxity represent the primary aesthetic concerns in this patient population. Targeted treatment with SP-HA (HASBV) to improve hydration and PLLA-SCA to address laxity have been shown to produce significant clinical outcomes by directly addressing these key dermal deficiencies. This approach forms the basis of the current study.
Phase 4
Recruiting
Erevna Innovations Inc.Andreas Nikolis, MD, PhD
Image of Center for Human Nutrition in Fayetteville, United States.

Higher Protein Diet for PCOS

18 - 50
Female
Fayetteville, AR
Polycystic ovary syndrome (PCOS) is a significant public health problem and is one of the most common hormonal disturbances affecting women of reproductive age. Women with PCOS are often insulin resistant, increasing their risk for cardiometabolic health problems (e.g., type 2 diabetes, heart disease, high blood pressure, sleep apnea, anxiety, depression, and stroke) especially if they are overweight. Lifestyle modifications, including dietary changes and regular physical activity, may alleviate metabolic dysfunction in women with PCOS and are often the first line of management for patients with PCOS. Several studies have identified protein as a key nutrient for regulation of energy balance, maintenance of skeletal muscle mass, and improving cardiometabolic health across the lifespan. However, the effect of increased protein intake (30% of total energy intake) on cardiometabolic health in women with PCOS has not been well-defined and mechanisms for these effects have not been identified. There is an evident need for well-designed, randomized controlled trials evaluating the efficacy of increased protein intake in women with PCOS on markers of cardiometabolic health. Preliminary data from collaborative projects with the investigators on this proposal suggest that increasing protein in the diet has the potential to improve markers of cardiometabolic health, potentially through improvements in body composition and/or changes in cortisol, energy metabolism, inflammation, and neurological regulators
Recruiting
Has No Placebo
Center for Human Nutrition
Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.Go to Trials
Image of William J. Hybl Sports Medicine and Performance Center in Colorado Springs, United States.

Moderate Aerobic Exercise for Menstrual Symptoms

18 - 40
Female
Colorado Springs, CO
The goal of this clinical trial is to evaluate the impact of moderate aerobic exercise on menstrual symptom management in sedentary women both using and not using hormonal contraceptives. The main questions it aims to answer are: Is there a reduction in physical and/or psychological menstrual cycle related symptom burden with participation in moderate aerobic exercise for sedentary women using and not using hormonal contraceptives? Is there a difference in physical and/or psychological menstrual cycle related symptom burden between hormonal contraceptive and non-hormonal contraceptive users? Is a moderate aerobic exercise intervention more effective in reducing physical and/or psychological menstrual related symptom burden for sedentary women using or not using hormonal contraceptives? Participants will: * Have their body composition assessed using dual energy X-ray absorptiometry pre and post exercise intervention. * Complete a Menstrual Symptom Index (MSi) to report daily menstrual cycle related symptom burden in addition to the Premenstrual Symptom Screening Tool (PSST) and Heavy Menstrual Bleeding (HMB) questionnaire monthly. * Utilize an at-home monitor to test urinary luteinizing hormone, estrone-3-glucuronide, and pregnanediol glucuronide approximately 10 times per month and report menstrual cycle length. * Record physical activity habits by continuously wearing a wrist-based accelerometer and chest-strap heart rate monitor during planned aerobic exercise sessions and complete the International Physical Activity Questionnaire (IPAQ) monthly. * Maintain their usual sedentary activity habits for one menstrual cycle followed by completion of an exercise intervention designed to progress individuals to meet minimum recommended aerobic physical activity guidelines of 150 minutes per week set by the American College of Sports Medicine for two menstrual cycles.
Recruiting
Has No Placebo
William J. Hybl Sports Medicine and Performance Center
Image of School of Allied Health Professions in Loma Linda, United States.

Seed Cycling for Menstrual Disorder

18 - 45
Female
Loma Linda, CA
The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea. The research seeks to provide evidence-based insights into the potential benefits of seed cycling as a holistic approach to women's reproductive health. It is expected that your participation will last 3 months. Procedures and Activities. You will be provided with and asked to consume specific seeds daily. The seeds are to be consumed as follows: follicular phase (the period from the first day of menstruation (day 1) to ovulation (day 14) in a typical 28-day cycle): 1 tablespoon flax seeds and 1 tablespoon pumpkin seeds, and luteal phase (the period between ovulation and the start of the next period; typically days 15-28): 1 tablespoon sunflower seeds and 1 tablespoon sesame seeds. Before the intervention and once monthly for a total of 3 cycles, you will be asked to complete an online menstrual health symptom questionnaire (MHSQ) and keep track of your menstrual cycle days on the built-in health tracking app on your electronic device. Risks. Some of the foreseeable risks or discomforts of your participation include the potential for mild gastrointestinal side effects, the potential for allergic reactions, and the possibility of no significant benefit. Benefits. Possible benefits include the potential for improved menstrual cycle regularity, the potential for a reduction in premenstrual syndrome (PMS) symptoms, and the potential for nutritional benefits. Societal benefits include additional knowledge on seed cycling to help manage menstrual regularity and PMS symptoms.
Waitlist Available
Has No Placebo
School of Allied Health Professions
Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.Go to Trials
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Estradiol and Elagolix for Menopause

42 - 64
Female
University Park, PA
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Phase 4
Recruiting
Noll LaboratoryW. Larry Kenney, Ph.D.
Have you considered Norgestimate And Ethinyl Estradiol clinical trials? We made a collection of clinical trials featuring Norgestimate And Ethinyl Estradiol, we think they might fit your search criteria.Go to Trials
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