Permapen

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Permapen

Treatment for

Gas Gangrene

What is Permapen

BenzylpenicillinThe Generic name of this drug

Treatment SummaryBenzylpenicillin (Penicillin G) is a common antibiotic used to treat infections caused by susceptible bacteria. It is injected into a muscle or vein because it cannot be absorbed through the stomach. Penicillin G is typically used to treat streptococcal infections, staphylococcal infections, and some bacterial infections caused by gram-positive aerobic bacilli. It may also be used to prevent certain bacterial infections in some cases. Penicillin G is not effective against gram-negative bacteria or anaerobic bacteria, and its effectiveness can vary depending on the region.

Bicillin L-Ais the brand name

image of different drug pills on a surface

Permapen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Permapen Affects PatientsPenicillin G is an antibiotic used to treat bacterial infections caused by certain bacteria. It works by stopping the bacteria from building a protective wall around itself, which eventually kills the bacteria. Penicillin G is effective against both gram-positive and gram-negative bacteria, and is resistant to a variety of beta-lactamases, including penicillinases, cephalosporinases, and extended spectrum beta-lactamases.

How Permapen works in the bodyPenicillin G works by attaching to proteins inside bacteria cells that help build the cell wall. This prevents the bacteria's cell wall from forming properly, leading to its destruction. Penicillin G may also interfere with a tool the bacteria use to stop its own destruction.

When to interrupt dosage

The measure of Permapen is based on the identified disorder, such as rat bite fever, Haverhill fever and Actinomycosis. The dosage is contingent upon the administration approach (e.g. Intramuscular; Intravenous or Injection, suspension) listed in the table below.

Condition

Dosage

Administration

Botulism

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Anthrax

Endocarditis

Listeriosis

Gram-Negative Bacterial Infections

Communicable Diseases

Bacterial Meningitis

Actinomycosis

Rat-Bite Fever

Fusospirochetosis

Rat-Bite Fever

Rheumatic Fever

Sepsis

Endocarditis

Lockjaw

Diphtheria

Empyema

Pericarditis

Gonorrhea

Meningitis, Meningococcal

Warnings

Permapen has one contraindication, so it should be avoided when confronting any of the circumstances specified in the accompanying table.Permapen Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Permapen.

Common Permapen Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Permapen Toxicity & Overdose RiskThe lowest toxic dose of this drug for rats has been measured at 8900mg/kg. Taking too much of this drug may cause seizures, and long-term use of high doses can lead to a decrease in white blood cells.

image of a doctor in a lab doing drug, clinical research

Permapen Novel Uses: Which Conditions Have a Clinical Trial Featuring Permapen?

85 active studies are being conducted to assess the potential of Permapen in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

19 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 1

Lockjaw

1 Actively Recruiting

Phase 4

Botulism

1 Actively Recruiting

Phase 2

Bacterial Meningitis

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Rheumatic Fever

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

0 Actively Recruiting

Gas Gangrene

0 Actively Recruiting

Empyema

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

1 Actively Recruiting

Phase 4

Rat-Bite Fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

0 Actively Recruiting

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Permapen Reviews: What are patients saying about Permapen?

5Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my autism re-evaluation last week, and it has helped to reduce my anxiety and itching much better than Zoloft did about 6 years ago. I would highly recommend this drug to anyone who needs help with anxiety.

5Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a godsend for my eating disorder. Not only does it help with anxiety, but it also helps immensely with the nausea I experience after eating.

5Patient Review

3/30/2022

Permapen for Itching

This treatment was very effective for me in relieving the itching associated with my pityriasis rosea. I didn't experience any negative side effects, and it made me feel much better overall as I waited for the rash to go away on its own.

5Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

This has been an amazing addition to my routine. I was struggling with anxiety and insomnia after being hospitalized for Covid, but this medication has helped me get a full night's sleep without any side effects.

5Patient Review

3/30/2022

Permapen for Itching

Hydroxyzine was very effective at quelling the itch and making me feel more comfortable. I didn't experience any major negative side effects, just some drowsiness. All in all, it was a very positive experience.

View All Reviews

Patient Q&A Section about permapen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much is benzathine penicillin?

"Bicillin L-A is a penicillin antibiotic that treats some infections caused by bacteria. However, it will not work for colds, the flu, or other viruses. The average retail price for the most common version of Bicillin L-A is $3,080.23, but it is currently available for 36% off at $1,956.80."

Answered by AI

What is benzathine penicillin used for?

"Penicillin G benzathine injection is used to treat bacterial infections such as mild to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, and pinta. It is also used to prevent rheumatic fever, chorea, rheumatic heart disease, or acute glomerulonephritis. This medicine is an antibiotic."

Answered by AI

How many units is 2ml of bicillin?

"Please see prescribing information for the Penicillin G Sodium brand of sterile powder for intramuscular use.

The size of the syringe is 2 mL and it contains 1,200,000 units of penicillin G. The needle is 21 gauge, thin-wall and 1-1/2-inches long. The syringe has 0.22 mEq of sodium per 1,200,000 units of penicillin G."

Answered by AI

What is bicillin used to treat?

"Bicillin L-A should never be given intravenously.

The antibiotic penicillin G benzathine is the best choice to treat syphilis. It is given as two injections, one into each hip or buttock muscle. They must be given at the same visit. Bicillin L-A must never be given through a vein."

Answered by AI

Clinical Trials for Permapen

Have you considered Permapen clinical trials? We made a collection of clinical trials featuring Permapen, we think they might fit your search criteria.

Have you considered Permapen clinical trials? We made a collection of clinical trials featuring Permapen, we think they might fit your search criteria.