Permapen

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Permapen

Treatment for

Gas Gangrene

What is Permapen

Benzylpenicillin

The Generic name of this drug

Treatment Summary

Benzylpenicillin (Penicillin G) is a common antibiotic used to treat infections caused by susceptible bacteria. It is injected into a muscle or vein because it cannot be absorbed through the stomach. Penicillin G is typically used to treat streptococcal infections, staphylococcal infections, and some bacterial infections caused by gram-positive aerobic bacilli. It may also be used to prevent certain bacterial infections in some cases. Penicillin G is not effective against gram-negative bacteria or anaerobic bacteria, and its effectiveness can vary depending on the region.

Bicillin L-A

is the brand name

image of different drug pills on a surface

Permapen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Permapen Affects Patients

Penicillin G is an antibiotic used to treat bacterial infections caused by certain bacteria. It works by stopping the bacteria from building a protective wall around itself, which eventually kills the bacteria. Penicillin G is effective against both gram-positive and gram-negative bacteria, and is resistant to a variety of beta-lactamases, including penicillinases, cephalosporinases, and extended spectrum beta-lactamases.

How Permapen works in the body

Penicillin G works by attaching to proteins inside bacteria cells that help build the cell wall. This prevents the bacteria's cell wall from forming properly, leading to its destruction. Penicillin G may also interfere with a tool the bacteria use to stop its own destruction.

When to interrupt dosage

The measure of Permapen is based on the identified disorder, such as rat bite fever, Haverhill fever and Actinomycosis. The dosage is contingent upon the administration approach (e.g. Intramuscular; Intravenous or Injection, suspension) listed in the table below.

Condition

Dosage

Administration

Botulism

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

Injection, powder, for solution - Intramuscular; Intravenous, , Intramuscular; Intravenous, Injection, powder, for solution, Intramuscular, Injection, suspension, Injection, suspension - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet, Tablet - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Suspension - Intramuscular, Suspension, Suspension - Oral, Injection, powder, for solution - Intravenous

Gonorrhea

Listeriosis

Empyema

Pericarditis

Rat-Bite Fever

Rheumatic Fever

Endocarditis

Lockjaw

Syphilis

Endocarditis

Actinomycosis

Communicable Diseases

Fusospirochetosis

Rat-Bite Fever

Meningitis, Meningococcal

Gas Gangrene

Anthrax

Diphtheria

Bacterial Meningitis

Warnings

Permapen has one contraindication, so it should be avoided when confronting any of the circumstances specified in the accompanying table.

Permapen Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Permapen.

Common Permapen Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Permapen Toxicity & Overdose Risk

The lowest toxic dose of this drug for rats has been measured at 8900mg/kg. Taking too much of this drug may cause seizures, and long-term use of high doses can lead to a decrease in white blood cells.

image of a doctor in a lab doing drug, clinical research

Permapen Novel Uses: Which Conditions Have a Clinical Trial Featuring Permapen?

85 active studies are being conducted to assess the potential of Permapen in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

17 Actively Recruiting

Not Applicable, Early Phase 1, Phase 2, Phase 4

Lockjaw

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Rheumatic Fever

0 Actively Recruiting

Botulism

0 Actively Recruiting

Bacterial Meningitis

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

0 Actively Recruiting

Gas Gangrene

0 Actively Recruiting

Empyema

1 Actively Recruiting

Phase 4

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

0 Actively Recruiting

Rat-Bite Fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Permapen Reviews: What are patients saying about Permapen?

Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my autism re-evaluation last week, and it has helped to reduce my anxiety and itching much better than Zoloft did about 6 years ago. I would highly recommend this drug to anyone who needs help with anxiety.

Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a godsend for my eating disorder. Not only does it help with anxiety, but it also helps immensely with the nausea I experience after eating.

Patient Review

3/30/2022

Permapen for Itching

This treatment was very effective for me in relieving the itching associated with my pityriasis rosea. I didn't experience any negative side effects, and it made me feel much better overall as I waited for the rash to go away on its own.

Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

This has been an amazing addition to my routine. I was struggling with anxiety and insomnia after being hospitalized for Covid, but this medication has helped me get a full night's sleep without any side effects.

Patient Review

3/30/2022

Permapen for Itching

Hydroxyzine was very effective at quelling the itch and making me feel more comfortable. I didn't experience any major negative side effects, just some drowsiness. All in all, it was a very positive experience.

Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my re-evaluation for autism last week, and it has helped with my anxiety and itchiness much better than Zoloft did about six years ago. I would highly recommend this to anyone who needs help in those areas.

Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

I started taking this to help me sleep at night due to anxiety after being hospitalized for Covid. It's been amazing- I'm finally able to get a full night's sleep without any side effects.

Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a lifesaver for me. I have an eating disorder and it's helped me immensely with both my anxiety around food and the nausea I experience when I do eat.

Patient Review

3/30/2022

Permapen for Itching

Hydroxyzine was very effective for me in managing the itchiness associated with pityriasis rosea. I only experienced drowsiness, which was to be expected, and it didn't cause any problems. All in all, a very positive experience.

Patient Review

8/4/2022

Permapen for Anxious

This medicine has helped my anxiety much better than Zoloft did to me about 6 years ago. I would highly recommend it to anyone who needs help with anxiety.

Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

Since taking this medication, I have been able to sleep through the night without any issues. I am a light sleeper by nature, but this has really helped me out.

Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been instrumental in my battle against anorexia. Not only does it help with the anxiety I experience around food, but it also helps immensely with the nausea that comes from eating.

Patient Review

3/30/2022

Permapen for Itching

I was pleased with how well hydroxyzine worked to ease my itching and make me feel more comfortable as I waited for my pityriasis rosea rash to go away. I would definitely recommend it to others in a similar situation.

Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my autism re-evaluation last week, and it has helped my anxiety much better than Zoloft did about 6 years ago. I would highly recommend this to anyone who needs help with anxiety.

Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

This medication has allowed me to get a full night's sleep for the first time in years. I highly recommend it for anyone struggling with anxiety or insomnia.

Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a godsend. It's not only helped my anxiety and eating habits, but it's also relieved the nausea I experience after eating.

4.3

Patient Review

4/28/2022

Permapen for Anxious

I take it for anxiety before bed it works just fine and helps me sleep.

4.3

Patient Review

4/28/2022

Permapen for Anxious

This medication works well for me in terms of reducing anxiety and helping me sleep at night.

4.3

Patient Review

4/28/2022

Permapen for Anxious

I take this before bed to help with my anxiety and it does the job perfectly. I sleep soundly through the night.

4.3

Patient Review

4/28/2022

Permapen for Anxious

This medication has been working well for me in terms of reducing anxiety and promoting sleep.

Patient Review

7/31/2022

Permapen for Anxious

I've found this treatment to be effective, though it can make me feel like a bit of a robot during the day. I have some short-term memory problems and confusion, which can be annoying, but overall this medication has helped me immensely.

Patient Review

7/31/2022

Permapen for Anxious

I'm a tall man, and this treatment worked well for me. The main downside is that I feel pretty zoned out during the day. It's confusing and frustrating at times, but it helps with anxiety tenfold.

Patient Review

7/31/2022

Permapen for Anxious

I'm a tall man and this treatment worked well for me. The main downside is that I feel like a robot on it-- very confused and out of sorts. This can be really annoying, especially when mixed with things like shorter term memory loss (I once waited in the wrong line at the store for 30 minutes). Overall though, I would recommend it to anyone struggling with anxiety or stress.

Patient Review

7/31/2022

Permapen for Anxious

I'm a tall guy and this medication worked great for me. The only downside is that I feel like a robot on it and get confused easily about things. I would recommend taking it before bed or as needed, but it really helped me out when I was going through a lot.

3.7

Patient Review

5/5/2022

Permapen for Hives

This medication quickly and effectively got rid of my chronic hives. However, it caused me to feel very sleepy and groggy afterwards, so I'm looking for another option now.

3.7

Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

This medication prescribed to me for insomnia does work in the sense that it has a calming effect. However, I find that I wake up feeling groggy and then later in the day feel like I've been drugged and need to sleep again. Not very helpful overall.

3.7

Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It was originally prescribed to me for anxiety and panic attacks; however, I noticed that my body began to build a tolerance to it and it stopped working as well as it was supposed to. Definitely not a long-term solution.

3.7

Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this medication for my insomnia and it does help me fall asleep. I wake up feeling groggy but after some tea, I'm doing well. However, about 10 hours later I feel drugged again and have to go back to sleep. So while it does help with falling asleep, it's not very helpful in terms of staying awake and functional during the day.

3.7

Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. I originally started taking it for anxiety and panic attacks; however, I noticed that my body began to build a tolerance to it and it no longer worked as well as it did before. Definitely not a long-term medication.

3.7

Patient Review

5/5/2022

Permapen for Hives

This medication quickly got rid of my hives where Benedryl failed. Though I still breakout occasionally, the itching is gone--which is a huge plus. The only downside is that it leaves me feeling drowsy and tired long after I should be awake and alert. So, I'm discussing other options with my doctor.

3.7

Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for insomnia. It helps me fall asleep but I wake up feeling groggy and then, about 10 hours later, I feel like I've been drugged and have to sleep again. Not very helpful.

3.7

Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It was prescribed to me for anxiety and panic attacks, but I noticed that my body began to build a tolerance to it and it no longer worked as well as it had before. Definitely not a long-term solution.

3.7

Patient Review

5/5/2022

Permapen for Hives

This medication quickly got rid of my chronic hives, which Benedryl did nothing for. Although it does make me groggy, the itching is gone. I'm currently looking for another alternative with my doctor.

3.7

Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this medication for my insomnia and it does help me fall asleep. I wake up feeling groggy, but after some tea I'm doing well. However, about 10 hours later I feel drugged again and have to go back to sleep. So while it does help me fall asleep, I don't think it's a very sustainable solution for my insomnia problem.

3.7

Patient Review

5/5/2022

Permapen for Hives

This medication took care of my chronic hives immediately where Benedryl did nothing. ! I may still break out, but the itching is completely gone. However, it leaves me feeling drowsy and groggy even after I'm up for the day.

3.7

Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It's helped with my anxiety and panic attacks, but I noticed that my body started to build up a tolerance to it and it stopped working as well as it did at first. Definitely not a long-term solution.

Patient Review

8/6/2022

Permapen for Anxious

I was prescribed this medication for my anxiety and it worked very well at first. I felt calm and normal again. However, the next day I experienced an elevated heart rate and felt out of it. I wish there was a pill that could provide the same relief without the side effects.

Patient Review

8/6/2022

Permapen for Anxious

Hydroxyzine worked well in the beginning to calm my anxiety and it let me sleep through the night. However, I experienced an elevated heart rate the next day which was very uncomfortable.

Patient Review

8/6/2022

Permapen for Anxious

This medication was very effective at treating my severe anxiety and panic attacks. I felt calm and normal again within 20 minutes of taking it, and slept through the night. However, the next day I experienced some side effects like an elevated heart rate and feeling out of it. Overall, this is a good medication but I would love to find one without the negative side effects.

Patient Review

8/6/2022

Permapen for Anxious

Hydroxyzine helped me feel normal again after just 20 minutes, which I loved. However, I experienced some less-than-ideal side effects the next day that included an elevated heart rate and feeling "out of it." All things considered, this medication is good but not perfect.

2.3

Patient Review

8/16/2022

Permapen for Itching

I was given this to help with my eczema and anxiety, but it actually made me more irritable and the itching didn't get any better. If you're struggling with depression, I would not recommend this medicine as it seems to make things worse.

2.3

Patient Review

8/16/2022

Permapen for Itching

I was given this medication to help with eczema-induced itching, as well as anxiety. Unfortunately, the former got worse instead of better, and the latter turned me into an intolerable person. If you have depression, I would stay away from this drug altogether.

2.3

Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night as needed and experienced heart palpitations about two hours after taking it. I had no idea that the medication could cause this side effect until reading other reviews.

2.3

Patient Review

8/16/2022

Permapen for Itching

I was given this for my eczema and anxiety. Unfortunately, it didn't help with the itching at all; if anything, it made me more irritable to the point where I couldn't stand being around myself. This medicine made my depression worse, so I had to stop taking it.

2.3

Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night and within about 2 hrs or so, I started experiencing heart palpitations. Didn’t realize it was from this medication until I read these reviews.

2.3

Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night and within about 2 hrs or so, I started experiencing heart palpitations. OMG!!! Didn’t realize it was from this medication until I read these reviews.

2.3

Patient Review

8/16/2022

Permapen for Itching

I didn't find this to be helpful for my eczema or anxiety. If anything, it made me more irritable and depressed.

2.3

Patient Review

3/15/2022

Permapen for Anxious

1.7

Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for my anxiety and depression. I was also hoping it would help me sleep better, but unfortunately it doesn't seem to work at all. In my opinion, it seems like doctors are prescribing this more as a placebo because they're afraid of lawsuits. This is really unfortunate because there are so many people suffering without any real help.

1.7

Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was really hoping this would help with my anxiety and depression, as well as promote better sleep. Unfortunately, I saw zero benefits from taking this medication. In my opinion, it's nothing more than a placebo that doctors are pushing because they're afraid of lawsuits.

1.7

Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was hoping this would help with my anxiety and depression, as well as improve my sleep. Unfortunately, I saw no benefits whatsoever. All it did was drain my wallet.

1.7

Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for my anxiety and depression. I was told it would also help me sleep, but it hasn't done anything at all. In my opinion, it's a placebo that doctors are overprescribing because they're afraid of lawsuits.

Patient Review

11/10/2022

Permapen for Anxious

This medication made my blood pressure go really high, which was especially dangerous when I had to go to the dentist. Overall, not a great experience.

Patient Review

11/10/2022

Permapen for Anxious

This medication made my blood pressure go sky high, which was especially dangerous when I had to go to the dentist.

Patient Review

11/10/2022

Permapen for Anxious

Do not take this medication if you're planning on going to the dentist anytime soon. It made my blood pressure go sky-high and was incredibly dangerous.

Patient Review

11/10/2022

Permapen for Anxious

Be aware that this medication can cause a significant rise in blood pressure, which can be dangerous in certain situations such as at the dentist.

Patient Q&A Section about permapen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much is benzathine penicillin?

"Bicillin L-A is a penicillin antibiotic that treats some infections caused by bacteria. However, it will not work for colds, the flu, or other viruses. The average retail price for the most common version of Bicillin L-A is $3,080.23, but it is currently available for 36% off at $1,956.80."

Answered by AI

What is benzathine penicillin used for?

"Penicillin G benzathine injection is used to treat bacterial infections such as mild to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, and pinta. It is also used to prevent rheumatic fever, chorea, rheumatic heart disease, or acute glomerulonephritis. This medicine is an antibiotic."

Answered by AI

How many units is 2ml of bicillin?

"Please see prescribing information for the Penicillin G Sodium brand of sterile powder for intramuscular use.

The size of the syringe is 2 mL and it contains 1,200,000 units of penicillin G. The needle is 21 gauge, thin-wall and 1-1/2-inches long. The syringe has 0.22 mEq of sodium per 1,200,000 units of penicillin G."

Answered by AI

What is bicillin used to treat?

"Bicillin L-A should never be given intravenously.

The antibiotic penicillin G benzathine is the best choice to treat syphilis. It is given as two injections, one into each hip or buttock muscle. They must be given at the same visit. Bicillin L-A must never be given through a vein."

Answered by AI

Clinical Trials for Permapen

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

New This Month

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc