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What is Azactam
AztreonamThe Generic name of this drug
Treatment SummaryCiprofloxacin is an antibiotic used to treat infections caused by certain types of bacteria. It is especially effective against gram-negative bacteria, which are commonly found in the meninges, bladder, and kidneys. However, it can cause an overgrowth of gram-positive bacteria, which can lead to a secondary infection.
Azactamis the brand name
Azactam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Azactam
Aztreonam
2009
15
Approved as Treatment by the FDA
Aztreonam, commonly known as Azactam, is approved by the FDA for 7 uses which include Urinary Tract Infection and Communicable Diseases .Urinary Tract Infection
Communicable Diseases
Skin Infections
Intraabdominal Infections
Gram-Negative Bacterial Infections
Septicemia
Lower Respiratory Tract Infection (LRTI)
Effectiveness
How Azactam Affects PatientsAztreonam is an antibiotic used to treat infections caused by certain types of bacteria, like Pseudomonas aeruginosa. It is sometimes called the "magic bullet" for aerobic gram-negative bacteria because it is very effective against them. Unlike other antibiotics, it does not get broken down by beta-lactamases (enzymes produced by some bacteria), so it can be used to treat infections that are resistant to other antibiotics. It works in a wide range of pH levels and can also stay active in the presence of human serum and without oxygen.
How Azactam works in the bodyAztreonam stops bacteria from making the cell walls they need to survive. It does this by attaching itself to a protein found in bacteria called penicillin binding protein 3 (PBP3). By binding to this protein, aztreonam prevents the third and final stage of cell wall synthesis. Bacteria then die as their own enzymes break down their cell walls. Aztreonam may also interfere with an enzyme that prevents bacteria from being destroyed.
When to interrupt dosage
Condition
Dosage
Administration
Osteomyelitis
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Septic Arthritis
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Intraabdominal Infections
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Urinary Tract Infection
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Gonorrhea
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Pseudomonas Aeruginosa Infection
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Bone and Joint Infections
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Lower Respiratory Tract Infection (LRTI)
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Cystic Fibrosis (CF)
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Skin Infections
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Gram-Negative Bacterial Infections
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Communicable Diseases
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Septicemia
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Febrile Neutropenia
100.0 mg/mL, 200.0 mg/mL, , 1000.0 mg, 2000.0 mg, 75.0 mg, 75.0 mg/mL, 500.0 mg
Injection, solution - Intravenous, , Intravenous, Injection, solution, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Powder, for solution, Powder, for solution - Respiratory (inhalation), Respiratory (inhalation), Powder, for suspension, Powder, for suspension - Respiratory (inhalation), Solution - Respiratory (inhalation), Solution
Warnings
There are 20 known major drug interactions with Azactam.Common Azactam Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Aztreonam.
Abacavir
Minor
Aztreonam may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Aztreonam may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Aztreonam may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Aztreonam may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Azactam Novel Uses: Which Conditions Have a Clinical Trial Featuring Azactam?
33 active clinical trials are currently in progress to assess the potential of Azactam to reduce Bone and Joint Infections, Cystic Fibrosis (CF) and Gram-Negative Bacterial Infections.Condition
Clinical Trials
Trial Phases
Bone and Joint Infections
0 Actively Recruiting
Septicemia
1 Actively Recruiting
Not Applicable
Gonorrhea
0 Actively Recruiting
Septic Arthritis
1 Actively Recruiting
Not Applicable
Gram-Negative Bacterial Infections
4 Actively Recruiting
Phase 2, Phase 3
Lower Respiratory Tract Infection (LRTI)
1 Actively Recruiting
Phase 3
Urinary Tract Infection
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Febrile Neutropenia
2 Actively Recruiting
Phase 2, Phase 4
Communicable Diseases
0 Actively Recruiting
Pseudomonas Aeruginosa Infection
0 Actively Recruiting
Osteomyelitis
6 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable
Cystic Fibrosis (CF)
0 Actively Recruiting
Intraabdominal Infections
4 Actively Recruiting
Not Applicable, Phase 4
Skin Infections
2 Actively Recruiting
Phase 2, Not Applicable
Azactam Reviews: What are patients saying about Azactam?
2.7Patient Review
4/29/2013 It worked similarly to Gentamycin, clearing my infection within a few days.
Patient Q&A Section about azactam
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Azactam a penicillin?
"Aztreonam is an antibiotic that was approved in 1986 for the treatment of Gram-negative bacterial infections via intravenous or intramuscular injection (Azactam®). This drug was marketed to treat bacterial infections and is safe for patients with penicillin allergies."
Answered by AI
What is Azactam used for?
"AZACTAM is used to treat serious bacterial infections. It may be used to treat infections in different parts of the body and is sometimes given with other antibiotics. Your doctor may have prescribed AZACTAM for another purpose."
Answered by AI
What bacteria does Azactam cover?
"Aztreonam is an antibiotic that is used to treat infections caused by bacteria. This includes infections of the bones, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis."
Answered by AI
What class of antibiotic is Azactam?
"This medication belongs to a class of drugs called Monobactams. It is not known if it is safe and effective in children younger than 9 months of age."
Answered by AI