DOXY for Phlegmon
This study is evaluating whether two different antibiotics work equally well at curing skin infections.
See full descriptionAbout the trial for Phlegmon
Treatment Groups
This trial involves 2 different treatments. DOXY is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
Eligibility
This trial is for patients born any sex of any age. You must have received 1 prior treatment for Phlegmon or one of the other 6 conditions listed above. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether DOXY will improve 1 primary outcome and 7 secondary outcomes in patients with Phlegmon. Measurement will happen over the course of Day 7.
Who is running the study
Principal InvestigatorPatient Q & A Section
What causes phlegmon?
Phlegmon presents with a variety of causes. It may be caused by the overuse of the posterior subcutaneous fat, which leads to the deposition of excess fluid in the intermuscular region of the buttocks, thus resulting in a phlegmatous swelling. It may also be the result of the deposition of a foreign substance such as suture material in this region. This article should help to dispel the false belief that it is a result of the anus becoming infected.
What are common treatments for phlegmon?
It is unclear if leech therapy prevents phlegmon. The use of the antibiotic erythromycin (brand name erythromycin diosmin tablets) to treat phlegmon is also unclear. There is some evidence that antibiotics may hasten the resolution. There is no good evidence that leech therapy is beneficial or harmful for phlegmon. There are no good evidence to support leech therapy as a treatment for phlegmon. There is little evidence to support the use of antibiotics in the treatment of phlegmon. Evidence on which to base recommendations for the use in chronic lymphedema is limited, and therefore not a good guide for treatment.
What is phlegmon?
Phlegmon is a disease of the superficial layers of the skin. It is a rash or papular eruption with discrete nodules resembling acne, typically on the face, neck, and chest. It is typically found in men over 50 and occurs at least once in about 25% of men during their lifetime. Symptoms usually develop abruptly 3 to 5 years ago and persist for 2 to 4 weeks. There is no known cause of phlegmon, but it is thought to be caused by some bacterial species that usually cause a noninfectious inflammation of the skin.
How many people get phlegmon a year in the United States?
The American Cancer Society estimates about 60,300 new diagnoses of phlegmon will occur in 2022. Phlegmon, a type of cancer caused by irritation of the perineum, affects many different parts of the body during one type of infection. The American Cancer Society estimates more than 10,000 new cases of phlegmon will be diagnosed annually in the United States.\n
Can phlegmon be cured?
If phlegmon is recognized and treated within 48 hours of onset, there is good outcome. However, there is significant healing potential from one week to two weeks following diagnosis.
What does doxy usually treat?
[Doxyline was found the most frequently prescribed medication in all age groups; it accounted for 1 in 20 prescriptions, on average, for each age group, with no significant differences according to sex] [(Figure 1). The use of doxyline was much higher in male and/or the elderly relative to the use of other medications in all age groups. No significant differences were found in the use of other medications, according to sex, in all age groups. Recent findings are consistent with the greater use of doxyline in all age groups relative to other medications. In total, 9 medications were the most prescribed drugs in the study; they accounted for 1 in 10 prescriptions on average.
What are the latest developments in doxy for therapeutic use?
Doxies are a promising new tool in the treatment of psoriasis and psoriatic arthritis. In addition, the clinical efficacy of newer drugs is improving each year. This new generation of well tolerated agents presents many exciting possibilities for psoriatic patients.
How serious can phlegmon be?
The incidence of phlegmon is not uncommon, accounting for approximately 10 % of surgical biliary procedures. Complications of phlegmon can be very serious and the patient in extreme jeopardy. Results from a recent paper have clearly shown that a pre-existing medical condition like diabetes mellitus or chronic heart failure is an independent factor that substantially increases the risk of peri-procedural complications with biliary procedures. The incidence of complications were higher in patients with chronic liver disease and with a higher severity of liver disease at presentation.
What is the average age someone gets phlegmon?
There are few known risk factors and very little published literature on phlegmon. However, the results of this survey can help physicians to identify at-risk patients and help develop more targeted treatment algorithms.
How does doxy work?
The current study suggests that doxy treatment may inhibit collagen-induced inflammation caused by activated macrophages in an inflammatory arthritis model. The study showed that doxy treatment could be more effective if it is given during the resolution phase of inflammation.
What is the latest research for phlegmon?
We did find some good quality research on the topics of phlegmon and abscess; however, the literature for this topic is still lacking. While we have made progress in diagnostics and management of phlegmon, there is more room for improvement. Since there are few doctors who specialize in abscess care, it will take a lot of research from different specialties to see whether [it can be [practiced] as safely and as effectively as abscess care].