Personalized Hydration Strategy for Acute Kidney Injury
(NEPTUNE Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Personalized Hydration Strategy for Acute Kidney Injury?
Research shows that personalized hydration strategies, such as those guided by urine flow rate and central venous pressure, are more effective in preventing acute kidney injury compared to fixed-rate hydration. These tailored approaches help reduce the risk of kidney damage after procedures like coronary interventions.12345
Is the personalized hydration strategy for acute kidney injury safe for humans?
Research shows that personalized hydration strategies, like those guided by urine flow rate or left ventricular end-diastolic pressure, are generally safe for preventing kidney injury in patients undergoing heart procedures. These strategies do not significantly increase the risk of pulmonary edema (fluid in the lungs), suggesting they are safe for use in humans.12678
How is the personalized hydration strategy treatment different from other treatments for acute kidney injury?
The personalized hydration strategy is unique because it tailors the hydration process based on individual patient factors like left ventricular end-diastolic pressure (a measure of heart function), contrast volume, and baseline kidney function, rather than using a fixed-rate approach. This method aims to optimize hydration to prevent kidney injury more effectively by considering each patient's specific needs.12349
What is the purpose of this trial?
The NEPTUNE triple-blind, active-placebo, adaptive, pragmatic, randomized trial aims to evaluate the effectiveness of a new intra-venous hydration strategy guided by left ventricular end-diastolic pressure (LVEDP), amount of contrast used, and baseline renal function, to prevent contrast-induced acute kidney injury (CI-AKI) and patient-oriented clinical endpoints in all-comer patients undergoing coronary angiogram and/or percutaneous coronary intervention (PCI).
Research Team
Guillaume Marquis-Gravel, MD
Principal Investigator
Montreal Heart Institute
Eligibility Criteria
This trial is for adults over 18 who are about to have a heart procedure like coronary angiogram or PCI and can attend follow-up visits. They should expect to live at least 6 more months. It's not for those in shock, having emergency procedures, recent contrast media exposure, severe heart valve disease, very weak hearts (LVEF <30%), or current kidney issues.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a personalized or standard hydration strategy during and after coronary angiogram and/or PCI
Follow-up
Participants are monitored for safety and effectiveness after treatment, with serum creatinine measured at 48 hours, 7 days, and 6 months
Treatment Details
Interventions
- Personalized hydration strategy
- Standard of care
Find a Clinic Near You
Who Is Running the Clinical Trial?
Guillaume Marquis-Gravel
Lead Sponsor
Montreal Heart Institute
Lead Sponsor
Université de Montréal
Collaborator
Canadian Institutes of Health Research (CIHR)
Collaborator