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Behavioural Intervention

tDCS + Cognitive Training for Dementia

N/A
Waitlist Available
Led By Kyrana Tsapkini, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before intervention, immediately after intervention
Awards & highlights

Study Summary

This trial tests if non-invasive brain stimulation and computerized cognitive training can improve executive functioning in people with PPA, MCI or dementia.

Who is the study for?
This trial is for right-handed individuals who have been clinically diagnosed with Primary Progressive Aphasia (PPA), Frontotemporal Dementia (FTD), Mild Cognitive Impairment (MCI) or mild Alzheimer's Disease, based on neuropsychological and language testing, MRI scans, and clinical assessment. Participants must speak English fluently and have at least a high-school education. Those with uncorrected vision/hearing issues, other learning disorders, inability to follow directions, severe psychiatric conditions or previous neurological disorders like stroke are excluded.Check my eligibility
What is being tested?
The study tests the effects of non-invasive brain stimulation using transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex combined with computerized cognitive training from BrainHQ. The goal is to improve executive functioning in patients with PPA associated with FTD or Alzheimer's Disease pathology as well as those with MCI/Alzheimer's Disease.See study design
What are the potential side effects?
Potential side effects of tDCS may include discomfort at the electrode site such as itching or tingling during application, headache, fatigue after treatment sessions, nausea or insomnia. However individual experiences can vary.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before intervention, immediately after intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and before intervention, immediately after intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Executive Composite Outcome
Change in Global Cognitive Scores
Change in language composite outcome
Secondary outcome measures
Change in Selective attention and cognitive flexibility
Change in attention and task switching
Change in level of Depressive Symptoms
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Active tDCS on the DLPFC onlyExperimental Treatment1 Intervention
Participants will receive active tDCS on the DLPFC-only intervention first and then receive active tDCS + Cognitive Intervention(s) after a three-month washout period.
Group II: Active tDCS on the DLPFC + Cognitive Intervention(s)Experimental Treatment2 Interventions
Participants will receive active tDCS on DLPFC + Cognitive Intervention(s) first and then receive only active tDCS Intervention after a three-month washout period.

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Who is running the clinical trial?

Ybrain Inc.Industry Sponsor
11 Previous Clinical Trials
636 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,259 Previous Clinical Trials
14,820,603 Total Patients Enrolled
Kyrana Tsapkini, PhDPrincipal InvestigatorJohns Hopkins University
6 Previous Clinical Trials
370 Total Patients Enrolled

Media Library

Home-based tDCS (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05978804 — N/A
Primary Progressive Aphasia Research Study Groups: Active tDCS on the DLPFC + Cognitive Intervention(s), Active tDCS on the DLPFC only
Primary Progressive Aphasia Clinical Trial 2023: Home-based tDCS Highlights & Side Effects. Trial Name: NCT05978804 — N/A
Home-based tDCS (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05978804 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities currently available to join this trial?

"According to clinicaltrials.gov, this experiment is enrolling patients as of now. The trial was initially advertised on August 10th 2023 and has been revised most recently on the 7th of August 2023."

Answered by AI

Am I qualified to be a research subject for this experiment?

"To be part of this trial, patients must have dementia and lie in the age range between 50 to 90 years. The study is seeking a total of fifty individuals."

Answered by AI

To what extent is this experiment being tested upon individuals?

"Affirmative. The clinicaltrials.gov website indicates that this trial, initiated on August 10th 2023, is actively enrolling participants. There are 50 spaces available at one medical institution."

Answered by AI

What is the intended outcome of this experiment?

"The primary goal of this clinical study is to evaluate the efficacy of intervention by tracking changes in executive composite outcome. Additionally, researchers will measure participants' attention and task switching with Trail Making Task and N-Back (2-back) scores, assess their working memory capacity via Digit Span Backward for verbal working memory as well as Spatial Span Backward for spatial working memory, and monitor depressive symptoms through Hamilton Depression Rating Scale (HAM-D)."

Answered by AI

Does this clinical trial cater to individuals younger than 45 years of age?

"This clinical trial is enrolling persons aged between 50 and 90 years old."

Answered by AI

Who else is applying?

What state do they live in?
Indiana
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
2023. "Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05978804.
All > Aphasia > Frontotemporal Dementia
~31 spots leftby Aug 2025
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