tDCS + Cognitive Training for Dementia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether combining non-invasive brain stimulation with brain exercises can improve thinking skills in people with memory and language issues. The researchers use transcranial direct current stimulation (tDCS) to gently stimulate the brain, alongside cognitive training activities. Participants will help determine if these methods can enhance mental abilities in conditions like Primary Progressive Aphasia or mild Alzheimer's. Individuals diagnosed with mild Alzheimer's or dementia who are proficient in English might be suitable for this study. As an unphased study, this trial offers a unique opportunity to contribute to innovative research that could lead to new ways to support cognitive health.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this method is safe for individuals with dementia?
Research has shown that using transcranial direct current stimulation (tDCS) at home is safe and well-tolerated. Studies have demonstrated its safe use for up to 20 days. tDCS helps improve cognitive function, enhancing how well the brain thinks and remembers. One study found that using tDCS at home is safe and practical for people with mild cognitive impairment (MCI), indicating it can be done easily and without issues.
Although tDCS is generally safe, consulting a doctor is important to determine if it's appropriate.12345Why are researchers excited about this trial?
Unlike traditional treatments for dementia that typically focus on medications to manage symptoms, the home-based tDCS (transcranial Direct Current Stimulation) approach offers a non-invasive method that targets the brain's dorsolateral prefrontal cortex (DLPFC) directly. Researchers are excited because this method not only involves electrical stimulation to enhance brain activity but also combines cognitive interventions to potentially improve cognitive function. This dual approach could offer a more holistic way to address cognitive decline, setting it apart from existing drug therapies that primarily aim to slow disease progression. Additionally, the ability to administer this treatment at home could make it more accessible and convenient for patients and caregivers.
What evidence suggests that this trial's treatments could be effective for dementia?
Studies have shown that transcranial direct current stimulation (tDCS) can improve thinking skills in people with Alzheimer's disease. Research indicates that individuals with Alzheimer's benefit more from tDCS than those with mild cognitive impairment (MCI) or other types of dementia. Using tDCS at home has proven safe and practical for people with memory and thinking problems, showing promise for enhancing these skills. Specifically, applying tDCS to a brain area involved in decision-making and problem-solving has improved attention and language skills. In this trial, participants will receive either active tDCS on the DLPFC combined with cognitive interventions or active tDCS on the DLPFC only. Although more research is needed, early findings suggest that combining tDCS with brain exercises could further enhance these benefits.12356
Who Is on the Research Team?
Kyrana Tsapkini, PhD
Principal Investigator
Johns Hopkins University
Are You a Good Fit for This Trial?
This trial is for right-handed individuals who have been clinically diagnosed with Primary Progressive Aphasia (PPA), Frontotemporal Dementia (FTD), Mild Cognitive Impairment (MCI) or mild Alzheimer's Disease, based on neuropsychological and language testing, MRI scans, and clinical assessment. Participants must speak English fluently and have at least a high-school education. Those with uncorrected vision/hearing issues, other learning disorders, inability to follow directions, severe psychiatric conditions or previous neurological disorders like stroke are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 50 treatment sessions of tDCS and/or cognitive training over 10 weeks
Washout
A three-month washout period between treatment phases
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Home-based tDCS
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
Ybrain Inc.
Industry Sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator