Colonoscopy Techniques for Inflammatory Bowel Disease
Trial Summary
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Dye Spraying Chromocolonoscopy, High Definition Colonoscopy for Inflammatory Bowel Disease?
Research shows that dye-spraying chromoendoscopy, a technique that uses special dyes to highlight areas in the colon, improves the detection of abnormal growths in patients with inflammatory bowel disease. This method is recommended by major medical societies for better detection of dysplasia (abnormal cells that can lead to cancer) compared to standard white light colonoscopy.12345
Is colonoscopy safe for patients with inflammatory bowel disease?
Colonoscopy, including techniques like dye-spraying chromoendoscopy and high-definition colonoscopy, is generally considered safe for patients with inflammatory bowel disease, although specific safety data is limited. These procedures are commonly used for monitoring and detecting changes in the colon, and while they are safe, they may be less comfortable for patients with severe inflammation.46789
How does the treatment Dye Spraying Chromocolonoscopy differ from other treatments for inflammatory bowel disease?
Dye Spraying Chromocolonoscopy is unique because it involves spraying a dye during a colonoscopy to enhance the visibility of the colon lining, making it easier to detect abnormal areas that might indicate dysplasia (abnormal cells that could lead to cancer). This technique is particularly useful for patients with long-standing inflammatory bowel disease, as it provides a more detailed view compared to standard colonoscopy methods.1391011
What is the purpose of this trial?
Inflammatory Bowel Disease (IBD) involving the colon is a known risk for colon cancer. There are two standards-of-care colonoscopy techniques used for screening all patients who suffer from IBD for more than eight years. One method is to obtain random biopsies throughout the colon and the other is by using dye spraying chromo-colonoscopy.This trial aims to study the difference between the two colonoscopy techniques during the era of high definition camera in detecting neoplastic lesions during screening patients with long-standing IBD.
Eligibility Criteria
This trial is for adults over 18 with a history of Ulcerative Colitis, Crohn's disease affecting the colon, or unclassified colitis lasting at least eight years, or any duration if also diagnosed with primary sclerosing cholangitis. Participants must have significant colon involvement and not had a total colectomy or recent colonoscopy.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo either High Definition White Light Colonoscopy (HDWLC) with biopsies every 10 cm or Dye Spraying Chromo-colonoscopy (DSC) based on randomization
Follow-up
Participants are monitored for safety and effectiveness after the colonoscopy procedure
Treatment Details
Interventions
- Dye Spraying Chromocolonoscopy
- High Definition Colonoscopy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor