Multiple Interventions for Orthostatic Intolerance
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it excludes those taking drugs that could worsen fast heart rates. It's best to discuss your current medications with the trial team.
Is clonidine generally safe for humans?
What makes this drug treatment for orthostatic intolerance unique?
This treatment is unique because it combines multiple drugs, such as midodrine and atomoxetine, which have shown effectiveness in increasing blood pressure and reducing symptoms in patients with orthostatic hypotension. The combination approach may offer a more comprehensive management of symptoms compared to using a single drug.678910
What evidence supports the effectiveness of clonidine as a drug for orthostatic intolerance?
Who Is on the Research Team?
Satish R Raj, MD MSCI
Principal Investigator
Vanderbilt University School of Medicine
Are You a Good Fit for This Trial?
This trial is for people who've felt dizzy or had a rapid heartbeat when standing up, lasting more than 6 months. It's not suitable for those with severe conditions like cancer or heart disease, or if they're taking drugs that could make their symptoms worse.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive various mechanistically unique medications to control heart rate and improve symptoms of orthostatic intolerance
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Abdominal binder
- Acetazolamide
- Atomoxetine
- Breathing Device
- Clonidine
- Drinking Water
- Entacapone
- Indomethacin
- Isosorbide Dinitrate
- IV Saline
- Mecamylamine
- Melatonin
- Memantine
- Midodrine
- Modafinil
- Octreotide
- Placebo
- Propranolol
- Sertraline
Acetazolamide is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Satish R. Raj
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
National Center for Advancing Translational Sciences (NCATS)
Collaborator