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Behavioural Intervention

Antibiotic Stewardship at Discharge for Pneumonia (ROAD Home Trial)

N/A

Waitlist Available

Led By Valerie M Vaughn, MD

Research Sponsored by University of Utah

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Have normal urinary anatomy

Admitted to a general care medicine service

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months; from discharge prescription

Awards & highlights

ROAD Home Trial Summary

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Who is the study for?

This trial is for adult patients hospitalized with pneumonia or a urinary tract infection (UTI) who have normal urinary anatomy, are generally healthy immune-wise, and are admitted to general care. They must not be on antibiotics for other infections and should have received certain antibiotics during their hospital stay.Check my eligibility

What is being tested?

The ROAD Home Intervention aims to reduce antibiotic overuse when patients with community-acquired pneumonia or UTI leave the hospital. It compares customized stewardship plans in some hospitals against standard practices in others, measuring antibiotic use after discharge.See study design

What are the potential side effects?

Since this study focuses on improving antibiotic use rather than testing new drugs, it does not directly involve side effects of medications. However, better stewardship may lead to fewer drug-related complications like resistance or adverse reactions.

ROAD Home Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My urinary system is normal.

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I am currently admitted to a general care unit at a hospital.

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I am not currently being treated for an infection.

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I was diagnosed with pneumonia at my last hospital discharge.

ROAD Home Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months; from discharge prescription

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months; from discharge prescription

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months; from discharge prescription for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Days of antibiotic overuse at hospital discharge

Secondary outcome measures

Number of cases with antibiotic-associated adverse events

Other outcome measures

Number of cases with 30-day C Difficile infection

Number of cases with 30-day mortality

Number of cases with 30-day readmission

+1 more

ROAD Home Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: ROAD Home InterventionExperimental Treatment1 Intervention

Hospitals randomized to receive the ROAD Home Intervention will receive an implementation intervention that includes external facilitation to support them in selecting and implementing evidence-based antibiotic stewardship strategies based on local context and the ROAD Home framework (https://academic.oup.com/cid/article/74/9/1696/6374407).

Group II: Stewardship as UsualActive Control1 Intervention

Hospitals randomized to the control group will continue usual antibiotic stewardship activities. Although control hospitals are part of the HMS collaborative, during the intervention period they will not receive any of the ROAD Home Intervention components including analysis of their baseline data or needs assessment, customized suite of stewardship strategies, supported decision-making in selecting ROAD Home strategies to implement, an implementation blueprint, adaptable stewardship tools, or external facilitation from study investigators.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor

1,099 Previous Clinical Trials

1,778,682 Total Patients Enrolled

University of MichiganOTHER

1,796 Previous Clinical Trials

6,377,916 Total Patients Enrolled

Valerie M Vaughn, MDPrincipal InvestigatorUniversity of Utah

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals currently being invited to join this research project?

"Per the information displayed on clinicaltrials.gov, this medical study is currently closed to new participants; it was initially posted on November 1st 2023 and most recently updated December 5th of the same year. However, there are still 283 other trials recruiting patients at present time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Reducing Overuse of Antibiotics at Discharge Home

Valerie Vaughn 2023. "Reducing Overuse of Antibiotics at Discharge Home". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06106204.