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Behavioral Intervention

HD-tDCS + Speech Therapy for Aphasia

N/A

Recruiting

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must be adults and have English-language fluency

Patients must be 18 or older

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b

Awards & highlights

Study Summary

This trial will look at how mild electricity and speech therapy can help stroke survivors with language issues. #strokerecovery

Who is the study for?

This trial is for adults over 18 with aphasia from left-sided brain damage like a stroke, who can speak English and are MRI-eligible. It's not for those with advanced neurodegenerative diseases, unmanaged seizure disorders, severe mental health issues, major hearing or vision problems, developmental disabilities, or MRI contraindications such as metal implants.Check my eligibility

What is being tested?

The study tests if mild electrical stimulation to the brain (HD-tDCS) combined with speech therapy helps language recovery in people who have speech difficulties after a stroke. Participants will receive this combination treatment and their progress will be monitored.See study design

What are the potential side effects?

Possible side effects of HD-tDCS may include discomfort at the electrode site on the head, itching or tingling during stimulation, headache, fatigue and in rare cases nausea. Speech therapy typically does not have physical side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am an adult who speaks and understands English fluently.

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I am 18 years old or older.

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I have difficulty with language due to a stroke or tumor on the left side of my brain.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 time points: pre-assessment, 10 weeks post-therapy cycle a and 10 weeks post-therapy cycle b for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Behavioral outcome

Secondary outcome measures

fMRI

Trial Design

2Treatment groups

Experimental Treatment

Group I: Speech TherapyExperimental Treatment1 Intervention

Participants will be randomized to receive either phonologic-focused speech therapy or semantic-focused speech therapy

Group II: HD-tDCSExperimental Treatment1 Intervention

Participants will be randomized to receive either anodal HD-tDCS or sham-tDCS.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Speech Therapy

2021

Completed Phase 2

~80

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor

610 Previous Clinical Trials

1,162,513 Total Patients Enrolled

6 Trials studying Aphasia

333 Patients Enrolled for Aphasia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this test seek participants who are senior citizens?

"Qualified applicants must be older than 18 years of age and not exceed 85 years in age."

Answered by AI

How many individuals have enrolled in the experiment thus far?

"Affirmative. According to the records on clinicaltrials.gov, this trial is actively recruiting and began enrolling patients since August 25th 2023. 200 individuals need to be recruited at a single medical centre as of last editing on 8/23/2023."

Answered by AI

For whom is this clinical experiment open?

"Qualified participants of this trial must be afflicted with aphasia and between the ages of 18-85. Approximately 200 individuals are expected to join this medical study."

Answered by AI

Are there currently any enrollment slots available for this investigation?

"Indeed, this clinical trial is actively recruiting participants. The details of the study were posted on August 25th 2023 and revised lastly on August 23rd in the same year according to information available from clinicaltrials.gov."

Answered by AI

Recent research and studies

StrokeJournal

The One-year Attributable Cost of Poststroke Aphasia

Ellis, Charles, Annie N. Simpson, Heather Bonilha, Patrick D. Mauldin, and Kit N. Simpson. 2012. “The One-year Attributable Cost of Poststroke Aphasia”. Stroke. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/strokeaha.111.647339.

NeuroRehabilitationJournal

Longitudinal Trends in Aphasia in the United States

Ellis, Charles, Clara Dismuke, and Kathryn K. Edwards. 2010. “Longitudinal Trends in Aphasia in the United States”. Neurorehabilitation. IOS Press. doi:10.3233/nre-2010-0616.

Proceedings of the National Academy of SciencesJournal

Noninvasive Cortical Stimulation Enhances Motor Skill Acquisition over Multiple Days Through an Effect on Consolidation

Reis, Janine, Heidi M. Schambra, Leonardo G. Cohen, Ethan R. Buch, Brita Fritsch, Eric Zarahn, Pablo A. Celnik, and John W. Krakauer. 2009. “Noninvasive Cortical Stimulation Enhances Motor Skill Acquisition over Multiple Days Through an Effect on Consolidation”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.0805413106.

Current BiologyJournal