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Supplement

Creatine monohydrate for Ulcerative Colitis

Phase < 1
Waitlist Available
Led By Mark Gerich, MD
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Study Summary

This trial will see if creatine can help make the barrier stronger, and therefore help reduce disease activity in ulcerative colitis.

Eligible Conditions
  • Ulcerative Colitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ulcerative Colitis
Secondary outcome measures
Clinical remission of ulcerative colitis disease activity.
Clinical response in ulcerative colitis disease activity.
Colonic inflammation
+4 more

Side effects data

From 2015 Phase 4 trial • 14 Patients • NCT01514630
71%
Cold and flu symptoms
29%
Diarrhea
21%
Stomach Discomfort
14%
Muscle Cramps
7%
Lightheaded
7%
Numbness and Tingling in hands
7%
Headache
7%
Indigestion
7%
Polydipsia
7%
Swelling in Hands
7%
Nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Creatine Monohydrate

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment armExperimental Treatment1 Intervention
6 patients with mild-moderate ulcerative colitis treated with creatine monohydrate 21 grams per day in three divided doses taken with water for 8 weeks.
Group II: Optional Open-Label Treatment armExperimental Treatment1 Intervention
Up to 6 patients, who were randomized to the placebo arm, will be given the option to continue with open-label creatine monohydrate treatment at 21 grams per day in three divided doses, taken with water, for 8 weeks. Only non-invasive testing will be performed.
Group III: Placebo armPlacebo Group1 Intervention
6 patients with mild-moderate ulcerative colitis treated with placebo (matching creatine monohydrate) 21 grams per day in three divided doses taken with water for 8 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Creatine monohydrate
2005
Completed Phase 4
~620

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,732 Previous Clinical Trials
2,143,548 Total Patients Enrolled
2 Trials studying Ulcerative Colitis
72 Patients Enrolled for Ulcerative Colitis
Mark Gerich, MDPrincipal InvestigatorUniversity of Colorado Denver, Division of Gastroenterology

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does my profile align with the criteria to join this experiment?

"Candidates must meet the criteria of 18-70 years old and have a diagnosis of colitis or ulcerative in order to be eligible for this clinical trial. At present, only 12 individuals are needed by researchers."

Answered by AI

Are there any current opportunities to join this trial?

"According to the details found on clinicaltrials.gov, this particular medical trial is not presently accepting candidates as it was last updated on February 18th 2022. Nevertheless there are 538 other trials that are currently enrolling patients."

Answered by AI

Does this clinical trial offer the opportunity to participate for those over sixty years of age?

"People aged between 18 and 70 may participate in this trial, with 106 studies available for those younger than 18 and 448 specifically aimed at individuals 65 or older."

Answered by AI

Who else is applying?

What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD)
2022. "Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02463305.
~0 spots leftby Apr 2025
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