Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies how creatine monohydrate affects ulcerative colitis. Creatine provides energy to colon cells, helping them form a tight barrier that may reduce inflammation. Creatine is critical for maintaining intestinal health under inflammatory stress.
Will I have to stop taking my current medications?
The trial allows certain medications like mesalamine and thiopurines if they have been used at stable doses for a specified period. However, you must stop using over-the-counter supplements and certain medications like NSAIDs and ACE inhibitors two weeks before and during the study.
Is creatine monohydrate safe for human use?
Creatine monohydrate is generally considered safe for healthy adults when taken at recommended doses (up to 3 grams per day). Some side effects like weight gain and gastrointestinal issues have been reported, but serious adverse effects are rare. It's important to ensure the product is free from contaminants and to consult a healthcare provider, especially for higher doses or if you have health concerns.12345
How does creatine monohydrate differ from other treatments for this condition?
Creatine monohydrate is unique because it enhances muscle performance during short, high-intensity exercises by increasing the muscle's creatine and phosphocreatine levels, which helps produce energy quickly. This makes it particularly beneficial for vegetarians who have lower natural creatine stores compared to those who consume meat.16789
What data supports the effectiveness of the drug Creatine monohydrate?
Who Is on the Research Team?
Mark Gerich, MD
Principal Investigator
University of Colorado Denver, Division of Gastroenterology
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive creatine monohydrate or placebo for 8 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Open-label extension (optional)
Participants from the placebo arm may opt into continuation of creatine monohydrate treatment for 8 weeks
What Are the Treatments Tested in This Trial?
Interventions
- Creatine monohydrate
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor