LTG-001 for Acute Pain
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you must stop all current medications, but it excludes those who use NSAIDs, benzodiazepines, opioids, or medications that affect heart rhythms. It's best to discuss your specific medications with the trial team.
What is the purpose of this trial?
The goal of this clinical trial is to learn if LTG-001 works to treat pain after third molar removal surgery in adults. It will also learn about the safety of LTG-001. The main questions it aims to answer are:Does drug LTG-001 treat the acute pain after surgical removal of impacted third molars (wisdom teeth) over 12 hours? How tolerable is LTG-001 after surgical removal of impacted third molars (wisdom teeth) over 12 hours?Researchers in Part 1 will compare drug LTG-001 to a placebo (a look-alike substance that contains no drug) and in Part 2 to a placebo and a comparator to see if drug LTG-001 treats the post-surgical pain.Participants will:Take LTG-001 one time after the surgical removal of impacted third molars. Remain at the clinic for 12 hours after study dosing and return after a week for a safety check up.Report the pain relief during the 12 hours after dosing to record changes in the post-operative pain
Eligibility Criteria
Adults who've had their impacted third molars (wisdom teeth) surgically removed and are experiencing acute pain can participate. Specific details about eligibility criteria are not provided, but typically participants must be in good health aside from the condition being studied.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take LTG-001 one time after the surgical removal of impacted third molars and remain at the clinic for 12 hours for monitoring
Follow-up
Participants return after a week for a safety check-up
Treatment Details
Interventions
- LTG-001
Find a Clinic Near You
Who Is Running the Clinical Trial?
Latigo Biotherapeutics
Lead Sponsor