DISC-0974 for Anemia in Chronic Kidney Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new drug called DISC-0974 in adults with chronic kidney disease who are not on dialysis and have anemia. It aims to see if the drug is safe and how it behaves in and affects the body.
Will I have to stop taking my current medications?
The trial requires a 2-day break from oral iron supplements and a 30-day break from certain anemia treatments like blood transfusions, ESAs, or IV iron before starting. Other medications are not specifically mentioned, so it's best to discuss with the study team.
How is the drug DISC-0974 different from other treatments for anemia in chronic kidney disease?
DISC-0974 is unique because it may offer a new approach to treating anemia in chronic kidney disease, potentially addressing limitations of current treatments like erythropoiesis-stimulating agents (ESAs), which some patients are resistant to. While existing treatments focus on stimulating red blood cell production, DISC-0974 might work through a different mechanism, although specific details about its action are not provided in the available research.12345
Who Is on the Research Team?
Will Savage, MD PhD
Principal Investigator
Disc Medicine
Are You a Good Fit for This Trial?
Adults with non-dialysis chronic kidney disease stages 2-5 and anemia can join this trial. They must have specific levels of hemoglobin, bilirubin, ferritin, and transferrin saturation. BMI should be between 18.5 to 45 kg/m2. People with recent heart attacks, strokes, certain infections or surgeries, or those on recent iron supplements or anemia treatments cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive single or multiple doses of DISC-0974 or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- DISC-0974
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Disc Medicine, Inc
Lead Sponsor