This trial is evaluating whether Treatment will improve 1 primary outcome and 5 secondary outcomes in patients with Kidney Failure, Chronic. Measurement will happen over the course of up to 5 years.
This trial requires 2750 total participants across 2 different treatment groups
This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
"Data from a recent study of the trials provide support for conclusions that the standard of care regimen is highly effective from the patients' perspective." - Anonymous Online Contributor
"Infections with pathogens such as tuberculosis and syphilis can cause kidney diseases. Furthermore, the development of nephritis can occur in people whose immune systems have failed to eliminate these pathogens. Diabetes, high blood pressure and tobacco smoking are all risk factors for kidney diseases." - Anonymous Online Contributor
"Over 12.9 million US adults are estimated to have CKD. This makes up about 7.1% of the adult population. Approximately 9.6 million individuals with CKD have some degree of end stage kidney disease. The most common cause of CKD is hypertension. CKD is on the rise among the United States population with a rate of increase between 1.5% and 2.0% per year. This increasing trend has been observed since 1980, and is now accelerating at four times the normal rate." - Anonymous Online Contributor
"Kidney disease was common in adults in the USA, affecting 1 in 9 people living in the USA in 2000 and affecting 1 in 4 people between the age of 5 and 64 years. The majority of people would have preferred to keep their kidney disease secret. They reported significant impact of living with kidney disease on family, work and other social and economic considerations. A national initiative to support people living with kidney disease may reduce associated personal, social and economic burden." - Anonymous Online Contributor
"Results from a recent clinical trial has shown that serum creatinine is the only independent predictor of mortality in patients with CKD. Other factors such as proteinuria should be considered in more specific contexts. We also found no relationship between the occurrence of CKD and a particular risk factor, although there was a strong association of diabetes." - Anonymous Online Contributor
"Although kidney diseases are highly prevalent, they are not inevitable. The development of kidney disease could be prevented at early stages, if there are no aggravating factors, such as smoking, and if the person seeks and completes an appropriate treatment for the cause of the disease. The treatment is only effective and feasible if the causative factors are removed while the disease is still reversible." - Anonymous Online Contributor
"Various techniques are used to treat kidney diseases, including dietary restrictions, blood or drug restriction, and avoidance of certain kinds of substances. There is a need to make more information about the effects of drug use and the use of certain herbal medicines and foods so that people can minimize potential harm in their everyday lives." - Anonymous Online Contributor
"The primary cause of kidney diseases is an imbalance between high concentration of uric acid in the urine and water losses due to perspiration. The loss of water due to perspiration is an important fact, particularly in elderly persons. As for the high concentration of uric acid in the urine, it occurs as a consequence of an increase in the kidney’s excretion of uric acid. The excretion of uric acid is affected by hyperuricemia (high concentration of hyperuricemia in the serum)." - Anonymous Online Contributor
"The condition of chronic kidney disease (CKD) is severe in terms of reduced quality of life, healthcare use, and mortality. Especially in this regard, women seem to present a higher risk of severe disease than males. The prevalence of CKD seems to be steadily increasing, especially in men. Recent findings show that an individual risk factor has been significantly associated with CKD in the general population in both men and women. However, a strong and reproducible association was established only in women." - Anonymous Online Contributor
"There are still several unknown risk factors that contribute to developing kidney diseases and [chronic kidney disease]. Although it seems like the average age people get kidney diseases is steadily increasing, the incidence of kidney diseases differs by gender and ethnicity. Women and African Americans are at a higher risk of developing chronic kidney disease. For men, [blood tests for creatinine(Cr) level] is the most used diagnostic tool to help identify individuals at risk. [CKDATAT:Kidney Disease Network of America Toxicity Score (CKD-USA)] is the first tool that provides an estimation of the risk of developing chronic kidney disease." - Anonymous Online Contributor
"In the last fifteen years, few new drugs for kidney diseases were developed, while in the previous fifteen years, we have seen new drugs for kidney diseases not only for kidney diseases, but also for other renal disorders, such as kidney function and proteinuria with or without renal disorders, as well as for kidney diseases and urinary diseases. So we can say that knowledge of kidney diseases is useful, but knowledge on kidney diseases do not advance very fast." - Anonymous Online Contributor
"Clinical trials for kidney diseases often require significant patient recruitment and monitoring of patients for outcomes; trials with large populations could require years to complete. On the basis of these data, patients who consider a trial should carefully consider possible risks when it is not required for their immediate care needs or they are on a specific therapy that they have ongoing access to." - Anonymous Online Contributor