Radiation + Androgen Suppression for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to compare the effects, good and/or bad of two treatment methods on subjects and their cancer.Proton beam radiation therapy is one of the treatments for men with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy (28 treatments) alone to proton therapy with androgen suppression therapy.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on certain blood thinners like warfarin or Plavix unless they can be stopped for treatment-related reasons.
Is the combination of radiation and androgen suppression therapy safe for prostate cancer treatment?
Studies show that proton beam therapy (a type of radiation) for prostate cancer generally has manageable side effects, with some patients experiencing mild to moderate issues like gastrointestinal and genitourinary problems. Combining it with androgen deprivation therapy (hormone therapy) is common, but the exact safety profile can vary, so discussing personal risks with a doctor is important.12345
How is proton beam therapy different from other treatments for prostate cancer?
Proton beam therapy (PBT) is unique because it uses protons to deliver high doses of radiation directly to the prostate tumor while minimizing exposure to surrounding healthy tissues, thanks to its precise dose deposition properties. This can potentially reduce side effects compared to traditional X-ray radiation therapies.56789
What data supports the effectiveness of the treatment Radiation + Androgen Suppression for Prostate Cancer?
Research shows that combining androgen deprivation therapy (ADT) with proton beam therapy (PBT) benefits patients with intermediate- and high-risk prostate cancer. Additionally, PBT has been shown to reduce the dose to normal tissues, potentially minimizing side effects while effectively targeting the tumor.145710
Who Is on the Research Team?
Carlos Vargas, MD
Principal Investigator
Proton Collaborative Group
Are You a Good Fit for This Trial?
Men with intermediate-risk prostate cancer who have not had previous prostate surgery, androgen suppression therapy, or pelvic radiation. They must be in good physical condition (ECOG 0-1), have a Gleason Score of 7, PSA levels between 10-20 ng/ml, T stage T2b-T2c, and no major medical issues that could affect the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive hypofraction proton therapy alone or with androgen suppression therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Androgen Suppression Therapy
- Proton Beam Radiation Therapy
Proton Beam Radiation Therapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
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Who Is Running the Clinical Trial?
Proton Collaborative Group
Lead Sponsor