Exercise Training for Depression in Multiple Sclerosis
(METS in MS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment FLEX-MS, Stretching Program, FLEX-MS, POWER-MS, Exercise Training Program, POWER-MS Exercise Regimen for depression in multiple sclerosis?
Research shows that exercise training can help reduce depressive symptoms in people with multiple sclerosis. Studies have found that exercise improves mood, reduces fatigue, and enhances quality of life in MS patients, suggesting that similar exercise programs like FLEX-MS and POWER-MS could be beneficial.12345
Is exercise training safe for people with multiple sclerosis?
How does the treatment FLEX-MS, POWER-MS differ from other treatments for depression in multiple sclerosis?
FLEX-MS and POWER-MS are unique because they focus on exercise training, which has been shown to improve depressive symptoms, fatigue, and quality of life in people with multiple sclerosis, unlike conventional therapies that often under-treat these symptoms. This approach is particularly beneficial as it is physically accessible and can be tailored to individuals with varying levels of mobility.23457
What is the purpose of this trial?
The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants.This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching program (FLEX-MS) for immediate and sustained reductions in the severity of depression among persons with MS who have MDD.
Research Team
Robert Motl, Ph.D
Principal Investigator
University of Illinois Chicago
Eligibility Criteria
This trial is for people aged 18-64 with Multiple Sclerosis (MS) and Major Depressive Disorder (MDD), who have internet access, speak English, and are willing to participate in exercise testing. They must not have had a relapse or taken steroids recently, should be relatively inactive based on specific questionnaires, and cannot have certain severe mental illnesses.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in either the POWER-MS or FLEX-MS exercise program to manage depression and improve health indicators
Immediate Follow-up
Assessment of exercise behavior, quality of life, physical activity, muscle strength, aerobic capacity, cognitive performance, depression severity, and fatigue severity
Long-term Follow-up
Continued monitoring of exercise behavior, quality of life, physical activity, muscle strength, aerobic capacity, cognitive performance, depression severity, and fatigue severity
Treatment Details
Interventions
- FLEX-MS
- POWER-MS
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Illinois at Chicago
Lead Sponsor
University of Alabama at Birmingham
Lead Sponsor
Congressionally Directed Medical Research Programs
Collaborator