Diet Modification for Chronic Kidney Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether increasing fruit and vegetable intake, including those high in potassium, can be safe and beneficial for people with chronic kidney disease. Researchers aim to determine if a combination of dietary changes, specifically more fruits and vegetables, and a medication called patiromer can help manage potassium levels. It suits adults with chronic kidney disease who have recently experienced high potassium levels and are on certain medications. As an unphased trial, this study provides a unique opportunity to contribute to understanding dietary impacts on kidney health.
Will I have to stop taking my current medications?
The trial requires that if you are taking RASS inhibitors, beta-blockers, or diuretics, you must be on stable doses for 2 weeks. If you are taking other potassium controlling agents, you cannot participate in the trial.
What prior data suggests that this diet modification is safe for chronic kidney disease patients?
Research has shown that eating more fruits and vegetables benefits people with chronic kidney disease (CKD). One study found that consuming three to four servings daily lowered the risk of kidney failure by 25%. Another study demonstrated that this diet reduced kidney damage, as indicated by lower protein levels in urine.
However, monitoring potassium levels is crucial, especially for those with CKD. Some fruits and vegetables contain high potassium levels, which can be harmful if not managed well. To address this, the study uses patiromer, a medication that helps control potassium levels, making it safer for participants to consume more fruits and vegetables.
Overall, evidence suggests that a diet rich in fruits and vegetables is generally safe and well-tolerated for CKD patients when potassium is managed.12345Why are researchers excited about this trial?
Researchers are excited about increasing fruit and vegetable intake for chronic kidney disease (CKD) because it's a natural, non-pharmacological approach that could complement or even reduce the need for standard treatments like medications to control blood pressure or dialysis. Unlike traditional methods, this dietary change focuses on enhancing overall nutrition while maintaining safe potassium levels with the help of patiromer, a medication that helps manage potassium in the blood. This approach not only targets kidney health but also promotes better cardiovascular health and overall well-being, making it a holistic option for CKD patients.
What evidence suggests that increasing fruits and vegetables might be an effective treatment for chronic kidney disease?
Research shows that eating more fruits and vegetables benefits people with chronic kidney disease. This trial will evaluate the effects of increased fruit and vegetable consumption in these patients while maintaining normokalemia with patiromer. Studies have found that a diet rich in plant-based foods might lower the risk of kidney failure. For example, one study discovered that people who ate at least two servings of fruits and vegetables daily had a lower risk of kidney failure than those who ate less. Additionally, diets high in fruits and vegetables can improve a measure of kidney health called ACR in people with mild issues. Overall, these findings suggest that eating more fruits and vegetables supports kidney health.13456
Who Is on the Research Team?
Nand Wadwha, MD
Principal Investigator
NY Health
Are You a Good Fit for This Trial?
This trial is for adults over 18 with chronic kidney disease (eGFR 15-44ml/min/1.73m2) and high potassium levels in their blood (≥5.0 mmol/L). They should be on stable doses of certain heart or blood pressure medicines for at least two weeks. People allergic to patiromer or already taking potassium controlling drugs can't join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Control Period
Participants document their normal daily consumption of fruits and vegetables in a food diary while taking Patiromer (Veltassa) daily
Dietary Intervention
Participants receive dietary/nutritional counseling and increase their fruit and vegetable intake, documenting choices in food diaries
Follow-up
Participants are monitored for safety and effectiveness after treatment, with continued use of Veltassa at the discretion of the investigator
What Are the Treatments Tested in This Trial?
Interventions
- Fruits and Vegetable increase
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nand Wadhwa
Lead Sponsor