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Cheese Consumption for Inflammation

N/A
Waitlist Available
Led By Angela M. Zivkovic, PhD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-65 years
Two or more components of metabolic syndrome: Central obesity, fasting blood triglycerides, plasma HDL cholesterol, blood pressure, fasting glucose, or BMI equal to or greater than 30
Must not have
Cancer
Gastrointestinal disorders including Crohn's Disease, colitis, diverticulitis, irritable bowel disease, celiac, malabsorption syndrome
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0, 1, 3, 6 hr postprandial
Awards & highlights

Summary

This trial is testing whether cheese or a cheese substitute impacts inflammation over six hours.

Who is the study for?
This trial is for adults aged 18-65 with metabolic syndrome, characterized by conditions like central obesity or high blood pressure. Participants should not have eating disorders, immune diseases, severe allergies to study foods, diabetes, recent changes in exercise or diet habits, a BMI over 40 or weight over 400 lbs., and must not be planning pregnancy.Check my eligibility
What is being tested?
The study compares the effects of consuming cheddar cheese versus vegan cheese on inflammation in individuals with metabolic syndrome. Over six hours, researchers will monitor how these two types of cheese influence inflammatory responses.See study design
What are the potential side effects?
Potential side effects are not specified but may include digestive discomfort due to lactose intolerance for those sensitive to dairy products. Vegan cheese could also cause issues if participants have unknown allergies to its components.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 65 years old.
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I have at least two symptoms of metabolic syndrome.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have cancer.
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I have a gastrointestinal disorder such as Crohn's, colitis, or celiac disease.
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I use anti-inflammatory pain medication every day.
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I do not have major liver or kidney diseases.
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I have an immune-related condition like autoimmune disease or asthma.
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I have lost or gained more than 10% of my weight in the last 6 months.
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I have Type II diabetes.
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I have not used corticosteroid medications in the last 12 weeks.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0, 1, 3, 6 hr postprandial
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 1, 3, 6 hr postprandial for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Inflammation
Secondary outcome measures
Plasma bone markers
Plasma glucose
Plasma lipid profile
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CheeseExperimental Treatment1 Intervention
Cheese sandwich plus supplemental beverage will deliver 40% of each participants' energy expenditure and will be made up of 50% of energy as fat, 35% of energy as carbohydrate and 15% of energy as protein. The sandwich will contain medium cheddar cheese and whole wheat bread. The supplemental beverage will contain fruit sorbet, glucose polymer, protein powder, high oleic sunflower oil, high polyunsaturated fatty acids (PUFA) sunflower oil, and canola oil.
Group II: Vegan cheeseActive Control1 Intervention
Non-dairy cheese alternative sandwich plus supplemental beverage will deliver 40% of each participants' energy expenditure and will be made up of 50% of energy as fat, 35% of energy as carbohydrate and 15% of energy as protein. The sandwich will contain vegan cheese and whole wheat bread. The supplemental beverage will contain fruit sorbet, glucose polymer, protein powder, cream of tartar, high oleic sunflower oil, high PUFA sunflower oil, and palm oil.

Find a Location

Who is running the clinical trial?

Dairy Research InstituteOTHER
17 Previous Clinical Trials
991 Total Patients Enrolled
4 Trials studying Metabolic Syndrome
270 Patients Enrolled for Metabolic Syndrome
University of California, DavisLead Sponsor
919 Previous Clinical Trials
4,720,872 Total Patients Enrolled
12 Trials studying Metabolic Syndrome
652 Patients Enrolled for Metabolic Syndrome
Angela M. Zivkovic, PhDPrincipal InvestigatorUniversity of California, Davis
1 Previous Clinical Trials
38 Total Patients Enrolled
1 Trials studying Metabolic Syndrome
38 Patients Enrolled for Metabolic Syndrome

Media Library

Cheddar cheese (N/A) Clinical Trial Eligibility Overview. Trial Name: NCT01803633 — N/A
Metabolic Syndrome Research Study Groups: Vegan cheese, Cheese
Metabolic Syndrome Clinical Trial 2023: Cheddar cheese Highlights & Side Effects. Trial Name: NCT01803633 — N/A
Cheddar cheese (N/A) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01803633 — N/A
~2 spots leftby Jul 2025