Hexadrol

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

106 FDA approvals

20 Active Studies for Hexadrol

Treatment for

Pemphigus

What is Hexadrol

DexamethasoneThe Generic name of this drug

Treatment SummaryDexamethasone (MK-125) is a type of steroid that was developed in 1957 and approved by the FDA in 1958. It is used to treat a wide range of conditions, including endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and others. In 2020, a clinical trial recommended the use of dexamethasone for COVID-19 patients with severe respiratory symptoms, as it was found to reduce deaths by one third in those requiring ventilation and by one fifth in those requiring oxygen.

Decadronis the brand name

image of different drug pills on a surface

Hexadrol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 106 uses which include Choroiditis and Drug Allergy .

Choroiditis

Helps manage Choroiditis

Drug Allergy

Helps manage Drug hypersensitivity reaction

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Berylliosis

Helps manage Berylliosis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Crohn Disease

Helps manage Regional Enteritis

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Bursitis

Helps manage Bursitis

Cushing Syndrome

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Optic Neuritis

Helps manage Optic Neuritis

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Ulcerative Colitis

Helps manage Ulcerative Colitis

Adrenocortical Hyperfunction

Inflammation

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Asthma

Helps manage Asthma

Erythroblastopenia

Helps manage Erythroblastopenia

Hypercalcemia

Helps manage Hypercalcemia

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Choroiditis

Helps manage Choroiditis

Tenosynovitis

Helps manage Tenosynovitis

Epicondylitis

Helps manage Epicondylitis

Cancer

Helps manage Cancer

Keratitis

Helps manage Keratitis

Trichinosis

Helps manage Trichinosis

Multiple Myeloma (MM)

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Adrenal Gland Hyperfunction

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

Iridocyclitis

Helps manage Iridocyclitis

Cushing's Syndrome

Immune Thrombocytopenia (ITP)

Helps manage Immune Thrombocytopenia (ITP)

Serum Sickness

Helps manage Serum Sickness

Berylliosis

Helps manage Berylliosis

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Regional Enteritis

Helps manage Regional Enteritis

severe Psoriasis

Helps manage severe Psoriasis

Synovitis

Helps manage Synovitis

Acute Coryza

Helps manage acute rheumatic carditis

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Edema of the cerebrum

Helps manage Edema of the cerebrum

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Atopic Dermatitis

Helps manage Atopic Dermatitis

Severe Seborrheic Dermatitis

Helps manage Severe Seborrheic Dermatitis

Malignant Lymphomas

Helps manage Malignant Lymphomas

exfoliative erythroderma

Helps manage exfoliative erythroderma

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Optic Neuritis

Helps manage Optic Neuritis

Synovitis

Helps manage Synovitis

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Bursitis

Helps manage Bursitis

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Sarcoidosis

Helps manage Sarcoidosis

Uveitis

Helps manage Uveitis

Chorioretinitis

Helps manage Chorioretinitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

Contact Dermatitis

Helps manage Contact Dermatitis

Tuberculosis

Helps manage Tuberculosis (TB)

Loeffler's syndrome

Helps manage Loeffler's syndrome

Pemphigus

Helps manage Pemphigus

Uveitis

Helps manage Uveitis

Iritis

Helps manage Iritis

Acute Gouty Arthritis

Helps manage Acute Gouty Arthritis

Hypercalcemia

Helps manage Hypercalcemia

Asthma

Helps manage Asthma

Rosacea

Helps manage Rosacea

Posttraumatic Osteoarthritis

Helps manage Posttraumatic Osteoarthritis

Brain

Helps manage Edema of the cerebrum

Inflammation

Iridocyclitis

Helps manage Iridocyclitis

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Ulcerative Colitis

Helps manage Ulcerative Colitis

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Hexadrol Affects PatientsCorticosteroids are drugs that reduce inflammation by blocking certain signals from being sent to the body. The amount of time these drugs stay in the body depends on how they are taken. As the amount of corticosteroids people need to take is usually more than what their bodies naturally produce, they have a wide therapeutic window. It is important to warn people taking corticosteroids that they are at risk for their body's natural hormone system being suppressed and for getting infections more easily.

How Hexadrol works in the bodyCorticosteroids reduce inflammation in the body by decreasing the activity of certain proteins and genes. This helps to shrink blood vessels and reduce the number of white blood cells going to the site of inflammation. Low doses of corticosteroids work to reduce inflammation and high doses can suppress your immune system. Taking glucocorticoids over a long period of time can cause an increase in sodium levels and a decrease in potassium levels.

When to interrupt dosage

The measure of Hexadrol is based upon the diagnosed ailment, like Pink Eye, Brain and Keloids Scars. The degree of dosage also depends on the technique of delivery as detailed in the table below.

Condition

Dosage

Administration

Chorioretinitis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Stevens-Johnson Syndrome

Ophthalmia, Sympathetic

Scleritis

Iritis

Sarcoidosis

Berylliosis

Hypercalcemia

Otitis Externa

Infection

Otitis Media

Necrobiosis Lipoidica

Uveitis

Seborrheic dermatitis

Ocular Infections, Irritations and Inflammations

Aspiration Pneumonitis

Keloids Scars

Communicable Diseases

Bacterial Infections

Communicable Diseases

Warnings

Hexadrol has nineteen contraindications, so it should be avoided for the conditions presented in the following table.Hexadrol Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Hexadrol.

Common Hexadrol Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Hexadrol Toxicity & Overdose RiskIn mice, the toxic dose of this drug taken orally is 6.5g/kg and intravenously is 794mg/kg. Taking too much of this drug over a long period of time can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle weakness, mood swings, psychosis, thinning of the skin, allergies, acne, increased body hair, reduced resistance to infections, facial swelling, high blood sugar, low calcium levels, low phosphorous levels, and slowed growth. If you think you’ve taken too much of this drug,

image of a doctor in a lab doing drug, clinical research

Hexadrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Hexadrol?

345 active studies are currently underway to determine the potential of Hexadrol for handling Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Thyroiditis

0 Actively Recruiting

Lupus

63 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1

Acute Coryza

0 Actively Recruiting

Inflammation

58 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Tuberculosis

2 Actively Recruiting

Phase 3, Phase 2

Pulmonary Eosinophilia

8 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 1

Open-angle glaucoma

45 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1

Uveitis

3 Actively Recruiting

Not Applicable, Phase 3

Asthma

92 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

53 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Acute Myeloid Leukemia (AML)

32 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 3

Diabetic Macular Edema

20 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Thrombocytopenia

0 Actively Recruiting

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Bacterial Infections

0 Actively Recruiting

Atopic Dermatitis

10 Actively Recruiting

Phase 2, Phase 3, Phase 4

Skin Diseases

0 Actively Recruiting

Trichinosis

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Patient Q&A Section about hexadrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Dexamethasone Sodium Phosphate injection used for?

"Dexamethasone injection is a medication used to treat severe allergic reactions, edema, gastrointestinal disease, and certain types of arthritis. It is also used for diagnostic testing."

Answered by AI

Is Decadron a steroid?

"Steroids like dexamethasone help to prevent the release of substances in the body that cause inflammation. Dexamethasone is used to treat many conditions such as allergies, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders."

Answered by AI

What is in a Decadron shot?

"This medication is used to treat a variety of conditions, including arthritis, blood/hormone disorders, allergic reactions, skin diseases, eye problems, breathing problems, bowel disorders, cancer, and immune system disorders."

Answered by AI

What are the side effects of dexamethasone?

"The possible side effects of the medication are an upset stomach, stomach irritation, vomiting, headache, dizziness, insomnia, restlessness, and depression."

Answered by AI

Clinical Trials for Hexadrol

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+

All Sexes

Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Our Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What We Think: We believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What We're Doing: We will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing we'll look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. We'll also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: We've already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. We've also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, we need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4

Waitlist Available

Has No Placebo

Sunnybrook Health Sciences Centre (+4 Sites)

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.