Lysodren

Adrenocortical Carcinoma, Cushing Syndrome

Treatment

2 FDA approvals

0 Active Studies for Lysodren

What is Lysodren

Mitotane

The Generic name of this drug

Treatment Summary

Mitotane is a medication derived from an insecticide used to treat adrenocortical tumors. It works by blocking the production of hormones in the adrenal cortex. Although it has been known to cause damage to the central nervous system, it does not affect the bone marrow.

Lysodren

is the brand name

image of different drug pills on a surface

Lysodren Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lysodren

Mitotane

2009

2

Approved as Treatment by the FDA

Mitotane, also known as Lysodren, is approved by the FDA for 2 uses which include inoperable Adrenocortical carcinoma and Adrenocortical Carcinoma .

inoperable Adrenocortical carcinoma

Adrenocortical Carcinoma

Effectiveness

How Lysodren Affects Patients

Mitotane is a medicine used to treat cancer of the adrenal glands. It changes the way the body processes cortisol, a hormone released by the adrenal glands, and can stop the cancerous cells from growing without completely destroying them. It makes the body produce more of a certain kind of cortisol, which lowers levels of other types of cortisol.

How Lysodren works in the body

We don't know exactly how it works, but studies suggest this drug alters how your body processes hormones and reduces activity in the adrenal cortex.

When to interrupt dosage

The recommended dosage of Lysodren is determined by the determined condition. The amount varies, contingent upon the method of delivery featured in the table below.

Condition

Dosage

Administration

Adrenocortical Carcinoma

, 500.0 mg

Tablet - Oral, , Oral, Tablet

Cushing Syndrome

, 500.0 mg

Tablet - Oral, , Oral, Tablet

Warnings

Lysodren has one contraindication and should not be taken in tandem with the ailments listed in the following table.

Lysodren Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Lysodren.

Common Lysodren Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Mitotane.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Mitotane.

5-androstenedione

Major

The metabolism of 5-androstenedione can be increased when combined with Mitotane.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Mitotane.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Mitotane.

image of a doctor in a lab doing drug, clinical research

Lysodren Novel Uses: Which Conditions Have a Clinical Trial Featuring Lysodren?

Two ongoing clinical trials are investigating the potential of Lysodren in providing therapeutic relief from Cushing's Syndrome.

Condition

Clinical Trials

Trial Phases

Adrenocortical Carcinoma

0 Actively Recruiting

Cushing Syndrome

0 Actively Recruiting

Lysodren Reviews: What are patients saying about Lysodren?

5

Patient Review

5/16/2008

Lysodren for Cushing's Syndrome

This medication has been prescribed for my Llaso Apso who was diagnosed with Cushing's Disease. The treatment has been working and he has not experienced, so far, any extreme side effects from the medication. He is a 13 year old canine, and has been on this medication for one year now.

5

Patient Review

12/1/2009

Lysodren for Cushing's Syndrome

I've been very happy with this treatment for my dog. She's been on it for over a year now with no problems.

5

Patient Review

8/17/2013

Lysodren for Cushing's Syndrome

My Boston Terrier has been on lysodren for a few months to treat cushings, and she's had no negative side effects so far. The only thing is that she gets a little drowsy.

4

Patient Review

5/9/2009

Lysodren for Cushing's Syndrome

We used this on our dog for cushings and it worked well.

3.7

Patient Review

12/28/2009

Lysodren for Cushing's Syndrome

My cocker spaniel has been on this medication for less than a year and has experienced some of the common side effects, such as drowsiness and loss of appetite. She also has atypical Cushing's which requires us to medicate with melatonin. This is likely adding to her drowsiness.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lysodren

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Lysodren used for?

"Lysodren is an anticancer medication used to treat cancer of the adrenal gland."

Answered by AI

What are side effects of mitotane?

"If you experience any of the following side effects, you should call your doctor: darkening of the skin, dizziness or lightheadedness, mental depression, nausea or vomiting, skin rash."

Answered by AI

What is Lysodren used for in dogs?

"Mitotane is an anticancer medication that is toxic to adrenal gland cells and is used to treat hyperadrenocorticism (Cushing's disease) or adrenal gland carcinoma. Its use in dogs and ferrets to treat adrenal disorders is 'off label' or 'extra label'."

Answered by AI

Is Lysodren a chemotherapy drug?

"Mitotane is a chemotherapy drug used to treat adrenal gland cancer. It may also be called Lysodren."

Answered by AI