Paxil Cr

Premature Ejaculation, Panic Disorder, Social Anxiety Disorder + 7 more
Treatment
3 FDA approvals
20 Active Studies for Paxil Cr

What is Paxil Cr

ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine, sold under the brand name Paxil, is a medication used to treat anxiety, depression, post-traumatic stress disorder, and symptoms of menopause. It is a type of selective serotonin reuptake inhibitor (SSRI), meaning it specifically affects serotonin levels in the brain. Paroxetine is usually well tolerated but can cause withdrawal symptoms when stopped. To reduce nausea, there is a controlled release formula of the drug available.
Paxilis the brand name
image of different drug pills on a surface
Paxil Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429

Approved as Treatment by the FDA

Paroxetine, also known as Paxil, is approved by the FDA for 3 uses which include Vasomotor Symptoms Associated With Menopause and Hot Flashes .
Vasomotor Symptoms Associated With Menopause
Helps manage Vasomotor Symptoms Associated With Menopause
Hot Flashes
Helps manage Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause

Effectiveness

How Paxil Cr Affects PatientsParoxetine is used to treat depression, anxiety, post-traumatic stress disorder, obsessive-compulsive disorder, and menopause symptoms by preventing the reabsorption of serotonin. It usually takes about 6 weeks for the effects to be felt. Taking it with other drugs that affect serotonin levels, like MAO inhibitors, can cause dangerous side effects. It is important to wait 2 weeks after discontinuing any MAO inhibitor before taking paroxetine.
How Paxil Cr works in the bodyParoxetine helps regulate serotonin levels in the body. It does this by blocking the serotonin (SERT) receptor from taking serotonin away from the synapse. This raises serotonin levels, which can relieve symptoms. Paroxetine has been proven to be more effective at blocking serotonin reuptake than other drugs in its class. The exact way Paroxetine treats menopausal symptoms is still unknown, but it may be related to how it affects temperature regulation. Paroxetine also has a mild effect on certain receptors in the body, including adrenergic, dopamine, histamine, and serotonin receptors. Its delayed effects may be

When to interrupt dosage

The suggested dosage of Paxil Cr is contingent upon the recognized situation, like Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The measure of dosage may differ, depending on the approach of delivery (e.g. Oral or Capsule - Oral) noted in the table beneath.
Condition
Dosage
Administration
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot Flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral

Warnings

Paxil Cr has five contraindications, and thus should not be engaged when one is faced with the conditions in the subsequent table.Paxil Cr Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
There are 20 known major drug interactions with Paxil Cr.
Common Paxil Cr Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Paxil Cr Toxicity & Overdose RiskThe most toxic dose of paroxetine for mice and rats is 350 mg/kg. The lowest reported fatal dose of paroxetine is 400 mg; the highest reported dose of paroxetine that someone has survived is 2000 mg. Symptoms of paroxetine overdose can include tiredness, fever, high blood pressure, fast heartbeat, nausea, vomiting, drowsiness, trembling, confusion, anxiety, headache, sweating, dilated pupils, seizures, tingling sensations, serotonin syndrome, muscle contraction, and changes in mental status. There is no known antidote for paroxetine overdose.
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Paxil Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Paxil Cr?

539 active trials are currently being conducted to examine the utility of Paxil CR in Post Traumatic Stress Disorder, Premature Ejaculation and Menopausal symptoms.
Condition
Clinical Trials
Trial Phases
Social Anxiety Disorder
15 Actively Recruiting
Not Applicable
Obsessive-Compulsive Disorder
66 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Generalized Anxiety Disorder
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Depression
212 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Post Traumatic Stress Disorder
236 Actively Recruiting
Not Applicable, Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Panic Disorder
13 Actively Recruiting
Not Applicable
Irritable Bowel Syndrome
5 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1
Hot Flashes
4 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Premature Ejaculation
0 Actively Recruiting
Hot flashes
19 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 3

Paxil Cr Reviews: What are patients saying about Paxil Cr?

5Patient Review
11/13/2014
Paxil Cr for Major Depressive Disorder
Paxil has been a game-changer for me. I've suffered from depression since childhood, and this medication has helped alleviate many of the symptoms. I'm so grateful to have found something that helps me feel more like myself.
5Patient Review
7/19/2015
Paxil Cr for Repeated Episodes of Anxiety
Paxil has been a life-saver for me. It's helped me manage my anxiety for 15 years without any negative side effects. I'm able to live a joyful and positive life thanks to this medication!
5Patient Review
4/7/2015
Paxil Cr for Panic Disorder
Paxil has been a game-changer for me. I haven't had a panic attack in 20 years, and even just forgetting to take it on vacation for 3 days brought the attacks back.
5Patient Review
9/23/2014
Paxil Cr for Panic Disorder
Paxil is an excellent drug for those suffering from OCD or panic disorder. I experienced very few side effects, and they were all manageable.
4.3Patient Review
6/15/2016
Paxil Cr for Repeated Episodes of Anxiety
I come from a family with a history of anxiety, so my FNP put me on Paxil CR about 10 years ago. Over time, the dosage increased as needed. I was really struggling to function without the medication; however, it has helped me immensely and allowed me to enjoy life much more.
3.3Patient Review
10/14/2018
Paxil Cr for Extreme Apprehension or Fear of Social Interaction
It took me an hour to ejaculate, but the results were worth it.
3Patient Review
7/28/2016
Paxil Cr for Anxiousness associated with Depression
Though this medication helped me, I was still anxious. My doctor decided to switch me to Wellbutrin, but that turned out to be a mistake. I got very sick from it and had to withdraw from the Paxil. Be careful when changing medications!
3Patient Review
9/6/2018
Paxil Cr for Extreme Apprehension or Fear of Social Interaction
I was convinced to take an SSRI in high school but Paxil had very little effect. The worst part was that it interfered with my sex life; I could barely ejaculate!
2.3Patient Review
1/25/2015
Paxil Cr for Repeated Episodes of Anxiety
I've tried a lot of different antidepressants and, by far, Paxil was the worst experience. I constantly got migraines (even though I'd never had them before), slept for 16 hours a day, and couldn't focus or function when I was awake because of the headaches. There are so many better options out there than this one.
2Patient Review
4/15/2014
Paxil Cr for Bipolar Depression
I found myself feeling really hyper one day, and then really down the next.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about paxil cr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Paxil CR used for?

"Paroxetine is a medication used to treat various forms of mental illness. These include depression, anxiety, panic attacks, and a severe form of premenstrual syndrome known as premenstrual dysphoric disorder. The drug works by correcting imbalances of the neurotransmitter serotonin in the brain."

Answered by AI

How long does it take for Paxil CR to work?

"In the first week or two, you may see some improvement in your sleep, energy levels, or appetite. This can be a good sign that the medication is working. However, it can take up to eight weeks for your mood and interest in activities to fully improve."

Answered by AI

Whats the difference between Paxil and Paxil CR?

"Paxil is a prescription medication that is used to treat depression, anxiety disorders, and other serious mental health problems. The medication is manufactured by GlaxoSmithKline and was the first medication to be approved for the treatment of social anxiety disorder (SAD). Paxil CR is the longer-acting, controlled-release version of the medication."

Answered by AI

What does the CR stand for in Paxil CR?

"Paxil and Paxil CR are indicated for the treatment of major depressive disorder, panic disorder and obsessive-compulsive disorder. Paxil was approved in May 1996."

Answered by AI

Clinical Trials for Paxil Cr

Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Psychotherapy for Depression

18 - 65
Female
Hamilton, Canada
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, The investigators ask questions about participants' physical and mental health and take blood samples.
Recruiting
Has No Placebo
St. Joseph's Healthcare HamiltonSheryl Green, PhD
Image of Stanford Digestive Health Clinic in Redwood City, United States.

MITI-001 for Irritable Bowel Syndrome

18 - 65
All Sexes
Redwood City, CA
While the pathophysiology of diarrhea-predominant irritable bowel syndrome (IBS-D) is complex and heterogeneous, dysbiosis of the gut microbiome is frequently observed, suggesting that a substantial subset of patients with irritable bowel syndrome (IBS) have symptoms that are initiated and/or perpetuated by a microbiome dysfunction. Successful randomized controlled trials (RCT) for IBS-D (Ford 2018; Black 2022) leveraging microbiome-targeted therapies (antibiotics or low microbiome fermentation diets) suggest the gut microbiome is at least partially involved in IBS symptoms. Furthermore, fecal microbiota transplantation (FMT) for patients with IBS-D has demonstrated promising results (El-Salhy 2020), supporting the possibility that altering the microbiome composition could ameliorate IBS-D symptoms. MITI-001 is a transplantable gut bacterial community composed of 157 live bacterial strains, encompassing 79 genera of commensal bacteria, that have been isolated from healthy donor stool, purified, and banked. The hypothesis of the proposed research is that MITI-001 can target the pathophysiologic lesion in a subset of IBS-D patients, restore the altered microbial metabolic process, and thus alleviate IBS-D symptoms.
Phase < 1
Waitlist Available
Stanford Digestive Health Clinic (+1 Sites)Sean P Spencer, MD, PhD
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Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Image of Duke University School of Medicine in Durham, United States.

Cognitive Rehabilitation for Anger in TBI and PTSD

18+
All Sexes
Durham, NC
This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD. The investigators hypothesize that compared to an active control group, Veterans randomized to the CALM group will demonstrate: * Significantly larger decreases in anger dysregulation, impulsivity, and executive dysfunction. * Significantly larger improvements in social and adaptive functioning including less aggression. * Significantly larger reduction in PTSD symptoms and suicidal ideation. The study targets Veterans who experience difficulties with anger and impulsivity due to TBI and PTSD. These issues are common, with up to 38% of Veterans with TBI also having PTSD. These conditions often make it challenging for Veterans to control their emotions and interact successfully in social and work settings. Our research will test the CALM (Cognitive Applications for Life Management) mobile app, which helps Veterans manage their goals, remember important tasks, and improve their attention. Initial tests of CALM have shown it can reduce levels of anger and related issues in Veterans. The investigators will conduct a study with 100 pairings of Veterans and a family member or friend. These pairs will be randomly assigned to one of two groups: one using the CALM mobile platform and the other receiving brain health education. Both groups will use their assigned intervention for three months and will receive support through videoconference calls at the beginning, middle, and end of the program.
Waitlist Available
Has No Placebo
Duke University School of MedicineEric Elbogen
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Integrated Treatment for PTSD and Chronic Pain

18+
All Sexes
New York, NY
Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as well as greater anxiety, depression, disability, and opioid use) compared to those with only one of those conditions. Gold standard treatments exist for both PTSD (e.g., Prolonged Exposure; PE) and chronic pain (e.g., Cognitive Behavioral Therapy for Chronic Pain; CBT-CP) and are generally offered sequentially (i.e., one at a time for the condition that is most prominent). Treating these conditions separately may overlook their interconnected nature, which may reduce efficacy and increase dropout. Thus, there is a need for an intervention to target both simultaneously, which may be more effective and efficient than treating conditions sequentially. This is a single-arm pilot study to assess the feasibility and acceptability of an integrated treatment for adults with comorbid PTSD and chronic pain. The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment draws from modules in PE and CBT-CP including psychoeducation, exposure to feared/avoided situations and activities, processing of exposures, behavioral activation, breathing and relaxation techniques, sleep hygiene, symptom monitoring, and structured homework assignments. Baseline and post-treatment assessments will be conducted.
Waitlist Available
Has No Placebo
Weill Cornell MedicineJoAnn Difede, PhD
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Inhaled Cannabis for PTSD

18+
All Sexes
Cave Creek, AZ
The rationale for the use of inhalational cannabis to potentially treat PTSD symptoms is based on the many reports of cannabis attenuating PTSD symptom expression among individuals with PTSD, including veterans. Study MJP2 is intended to build off MJP-1 through use of a larger sample size, a parallel study design, and subjective bias mitigation methods to re-examine the use of inhaled high THC-containing cannabis versus placebo for management of PTSD symptoms in a U.S. Veteran sample. Together these studies are intended to provide valuable insights on the already widespread use of cannabis in individuals with PTSD, for which there is currently a lack of controlled evidence available reflective of this real-world use.
Phase 2
Waitlist Available
Scottsdale Research Institute
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Integrated Health Care for Post-Traumatic Stress Disorder

18+
All Sexes
Phoenix, AZ
The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with posttraumatic stress disorder (PTSD). The main aims are: 1. To evaluate the impact of integrative care approaches on functional outcomes among Veterans with PTSD. 2. To examine factors relevant to the implementation of integrated treatments for PTSD from the perspective of patients, providers and administrators in the VA Healthcare System. Participants will: 1. Complete assessments at the beginning of the study and 12- and 24-weeks later. 2. Engage in 12 weeks of integrated care, with the type being randomly assigned.
Waitlist Available
Has No Placebo
VA Phoenix Healthcare System (+4 Sites)
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