Sertraline Hydrochloride

Bulimia Nervosa, Panic Disorder, Social Anxiety Disorder + 5 more
Treatment
10 FDA approvals
20 Active Studies for Sertraline Hydrochloride

What is Sertraline Hydrochloride

SertralineThe Generic name of this drug
Treatment SummarySertraline is a type of antidepressant medication, also known as an SSRI (selective serotonin reuptake inhibitor). It is similar to other SSRI drugs like Citalopram or Fluoxetine. It may take several weeks before the positive effects of sertraline are seen. It is generally better tolerated than other antidepressant medications, meaning it has fewer side effects such as drowsiness, dizziness, and blurred vision.
Sertraline Hydrochlorideis the brand name
image of different drug pills on a surface
Sertraline Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sertraline Hydrochloride
Sertraline
1992
502

Approved as Treatment by the FDA

Sertraline, also known as Sertraline Hydrochloride, is approved by the FDA for 10 uses like Panic Disorder and Social Anxiety Disorder (SAD) .
Panic Disorder
Social Anxiety Disorder (SAD)
Post Traumatic Stress Disorder (PTSD)
Obsessive Compulsive Disorder (OCD)
Premenstrual Dysphoric Disorder (PMDD)
Social Anxiety Disorder
Depression
Post Traumatic Stress Disorder
Panic Disorder
Obsessive-Compulsive Disorder

Effectiveness

How Sertraline Hydrochloride Affects PatientsSertraline helps to relieve symptoms of depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder by blocking the reabsorption of serotonin. Studies have also found that it can help improve thinking in people with depression. It has fewer side effects than other medications used to treat depression, such as drowsiness, constipation, and changes in heart rate. It usually takes 4-6 weeks for the drug to start working and its full effects to be seen, although the reason for this is not yet known.
How Sertraline Hydrochloride works in the bodySertraline blocks the reuptake of serotonin in the brain, which increases the amount of serotonin available to help regulate mood. This change in serotonin levels is believed to be responsible for the drug's ability to improve symptoms of depression and other anxiety disorders. In animal studies, sertraline has been shown to reduce the activity of norepinephrine receptors. It also has weak effects on the uptake of norepinephrine and dopamine, but does not affect the activity of the monoamine oxidase enzyme.

When to interrupt dosage

The suggested amount of Sertraline Hydrochloride is contingent upon the confirmed condition, comprising Social Anxiety Disorder, Obsessive-Compulsive Disorder and Post Traumatic Stress Disorder. The measure of dosage is contingent upon the approach of administration (e.g. Tablet, film coated or Concentrate) as stated in the table hereunder.
Condition
Dosage
Administration
Bulimia Nervosa
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Panic Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Social Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Obsessive-Compulsive Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Generalized Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Depression
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Post Traumatic Stress Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release
Binge-Eating Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Sertraline Hydrochloride presents five contraindications and should not be taken together with the ailments presented in the following table.Sertraline Hydrochloride Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sertraline may interact with Pulse Frequency
There are 20 known major drug interactions with Sertraline Hydrochloride.
Common Sertraline Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of serotonin syndrome can be increased when Sertraline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sertraline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Sertraline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Sertraline.
Azelastine
Major
Sertraline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Sertraline Hydrochloride Toxicity & Overdose RiskThe toxic dose of sertraline in rats is over 2000 mg/kg, while it is 419 - 548 mg/kg in mice and 1327 - 1591mg/kg in rats. Signs and symptoms of an overdose include drowsiness, vomiting, fast heartbeat, nausea, dizziness, restlessness, and shaking. Rarely, serious medical conditions such as serotonin syndrome, high or low blood pressure, loss of consciousness, slow heartbeat, irregular heartbeat, confusion, hallucinations, and pancreatitis may occur. Fatal overdoses from sertraline alone are rare, but may occur when taken with other drugs.
image of a doctor in a lab doing drug, clinical research

Sertraline Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Sertraline Hydrochloride?

526 investigations are actively assessing the potential of Sertraline Hydrochloride to ameliorate Bulimia Nervosa, Premenstrual Dysphoric Disorder and Obsessive-Compulsive Disorder.
Condition
Clinical Trials
Trial Phases
Depression
213 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Generalized Anxiety Disorder
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Post Traumatic Stress Disorder
239 Actively Recruiting
Not Applicable, Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Bulimia Nervosa
0 Actively Recruiting
Obsessive-Compulsive Disorder
67 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Panic Disorder
14 Actively Recruiting
Not Applicable
Social Anxiety Disorder
16 Actively Recruiting
Not Applicable
Binge-Eating Disorder
2 Actively Recruiting
Phase 2, Not Applicable

Sertraline Hydrochloride Reviews: What are patients saying about Sertraline Hydrochloride?

5Patient Review
7/3/2022
Sertraline Hydrochloride for Depression
I was really stressed out and constantly worrying, but I decided to give these a try. They made me feel awful for the first week, but after that my life changed for the better. If you're in a bad place, I advise you to consider taking them and put up with the side effects for the first week.
4Patient Review
8/24/2022
Sertraline Hydrochloride for Depression
My wife calls these "anti-divorce drugs" because they work so well for me. I'm really grateful to have found something that helps keep our marriage strong.
3.7Patient Review
9/10/2022
Sertraline Hydrochloride for Posttraumatic Stress Syndrome
I would recommend starting with a lower dosage than what my doctor originally prescribed me. I started out at 50 mg and had to get it lowered to 25 mg because of the unpleasant side effects. However, the medication was much more effective after the two weeks of use.
3Patient Review
8/4/2022
Sertraline Hydrochloride for Depression
I haven't seen much improvement since starting this medication. I'm still experiencing the same level of depression, suicidal thoughts, and lack of appetite and sleep.
2.7Patient Review
9/7/2022
Sertraline Hydrochloride for Anxiousness associated with Depression
I had to increase my dosage of sertraline due to worsening anxiety and depression. I was doing well on the drug in the past, but now after increasing my dosage, I feel worse. Can anyone tell me if this is normal and if the drug will eventually start working again?
2.3Patient Review
6/28/2022
Sertraline Hydrochloride for Posttraumatic Stress Syndrome
I've been taking sertraline for a while now, and I have to say that I haven't seen many benefits. If anything, it's made things worse. I've gained a lot of weight, I'm constantly tired, and my mood swings are through the roof. In my opinion, this medication is not meant to be taken for long-term use.
1.7Patient Review
9/26/2022
Sertraline Hydrochloride for Depression
I tried this medication for insomnia and was very disappointed. I took 25 mg the first night and could not fall asleep, then 50 mg the second night with no results. On the third night, I took 75 mg and still saw no effect whatsoever. At that point, I stopped taking the prescription entirely.I don't understand why my doctor prescribed me this depression medication for insomnia in the first place; after reading some of these reviews, I wouldn't have taken it even if she upped the dosage.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sertraline hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the main side effects of sertraline?

"Nausea: Try taking sertraline with or after food. Headaches: Make sure you rest and drink plenty of fluids. Insomnia: Take sertraline first thing in the morning. Sleepiness: Feel free to take naps. Diarrhea: Drink lots of fluids. Dry mouth: Suck on ice chips or sugar-free hard candy. Dizziness: Get up slowly from a lying or sitting position. Fatigue: Drink lots of fluids and get plenty of rest."

Answered by AI

Is sertraline hydrochloride a Xanax?

"There are two different brand names for alprazolam- Xanax and Niravam. Alprazolam belongs to the drug class of benzodiazepines, while sertraline- another brand name drug- is placed under the class of selective serotonin reuptake inhibitor antidepressants."

Answered by AI

Does sertraline hydrochloride make you sleep?

"The two most common side effects of sertraline (Zoloft) are fatigue and tiredness. If you're using sertraline to treat depression, the fatigue and tiredness from the medication can be compounded by the effects of depression on your mood."

Answered by AI

What is the use of sertraline hydrochloride?

"Sertraline is used to treat mental health conditions including depression, obsessive-compulsive disorder, panic attacks, and posttraumatic stress disorder."

Answered by AI

Clinical Trials for Sertraline Hydrochloride

Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Image of Duke University School of Medicine in Durham, United States.

Cognitive Rehabilitation for Anger in TBI and PTSD

18+
All Sexes
Durham, NC
This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD. The investigators hypothesize that compared to an active control group, Veterans randomized to the CALM group will demonstrate: * Significantly larger decreases in anger dysregulation, impulsivity, and executive dysfunction. * Significantly larger improvements in social and adaptive functioning including less aggression. * Significantly larger reduction in PTSD symptoms and suicidal ideation. The study targets Veterans who experience difficulties with anger and impulsivity due to TBI and PTSD. These issues are common, with up to 38% of Veterans with TBI also having PTSD. These conditions often make it challenging for Veterans to control their emotions and interact successfully in social and work settings. Our research will test the CALM (Cognitive Applications for Life Management) mobile app, which helps Veterans manage their goals, remember important tasks, and improve their attention. Initial tests of CALM have shown it can reduce levels of anger and related issues in Veterans. The investigators will conduct a study with 100 pairings of Veterans and a family member or friend. These pairs will be randomly assigned to one of two groups: one using the CALM mobile platform and the other receiving brain health education. Both groups will use their assigned intervention for three months and will receive support through videoconference calls at the beginning, middle, and end of the program.
Waitlist Available
Has No Placebo
Duke University School of MedicineEric Elbogen
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Integrated Treatment for PTSD and Chronic Pain

18+
All Sexes
New York, NY
Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as well as greater anxiety, depression, disability, and opioid use) compared to those with only one of those conditions. Gold standard treatments exist for both PTSD (e.g., Prolonged Exposure; PE) and chronic pain (e.g., Cognitive Behavioral Therapy for Chronic Pain; CBT-CP) and are generally offered sequentially (i.e., one at a time for the condition that is most prominent). Treating these conditions separately may overlook their interconnected nature, which may reduce efficacy and increase dropout. Thus, there is a need for an intervention to target both simultaneously, which may be more effective and efficient than treating conditions sequentially. This is a single-arm pilot study to assess the feasibility and acceptability of an integrated treatment for adults with comorbid PTSD and chronic pain. The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment draws from modules in PE and CBT-CP including psychoeducation, exposure to feared/avoided situations and activities, processing of exposures, behavioral activation, breathing and relaxation techniques, sleep hygiene, symptom monitoring, and structured homework assignments. Baseline and post-treatment assessments will be conducted.
Waitlist Available
Has No Placebo
Weill Cornell MedicineJoAnn Difede, PhD
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Inhaled Cannabis for PTSD

18+
All Sexes
Cave Creek, AZ
The rationale for the use of inhalational cannabis to potentially treat PTSD symptoms is based on the many reports of cannabis attenuating PTSD symptom expression among individuals with PTSD, including veterans. Study MJP2 is intended to build off MJP-1 through use of a larger sample size, a parallel study design, and subjective bias mitigation methods to re-examine the use of inhaled high THC-containing cannabis versus placebo for management of PTSD symptoms in a U.S. Veteran sample. Together these studies are intended to provide valuable insights on the already widespread use of cannabis in individuals with PTSD, for which there is currently a lack of controlled evidence available reflective of this real-world use.
Phase 2
Waitlist Available
Scottsdale Research Institute
Have you considered Sertraline Hydrochloride clinical trials? We made a collection of clinical trials featuring Sertraline Hydrochloride, we think they might fit your search criteria.Go to Trials
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Peer-Delivered Behavioral Activation for Depression

18+
All Sexes
Detroit, MI
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.
Waitlist Available
Has No Placebo
Detroit Recovery Project
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Transcranial Direct Current Stimulation for Depression

18 - 85
All Sexes
San Diego, CA
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.
Recruiting
Has No Placebo
UCSD Interventional Psychiatry
Have you considered Sertraline Hydrochloride clinical trials? We made a collection of clinical trials featuring Sertraline Hydrochloride, we think they might fit your search criteria.Go to Trials
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