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What is Sertraline Hydrochloride
SertralineThe Generic name of this drug
Treatment SummarySertraline is a type of antidepressant medication, also known as an SSRI (selective serotonin reuptake inhibitor). It is similar to other SSRI drugs like Citalopram or Fluoxetine. It may take several weeks before the positive effects of sertraline are seen. It is generally better tolerated than other antidepressant medications, meaning it has fewer side effects such as drowsiness, dizziness, and blurred vision.
Sertraline Hydrochlorideis the brand name
Sertraline Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sertraline Hydrochloride
Sertraline
1992
502
Approved as Treatment by the FDA
Sertraline, also known as Sertraline Hydrochloride, is approved by the FDA for 5 uses like Social Anxiety Disorder and Panic Disorder .Social Anxiety Disorder
Panic Disorder
Post Traumatic Stress Disorder
Depression
Obsessive-Compulsive Disorder
Effectiveness
How Sertraline Hydrochloride Affects PatientsSertraline helps to relieve symptoms of depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder by blocking the reabsorption of serotonin. Studies have also found that it can help improve thinking in people with depression. It has fewer side effects than other medications used to treat depression, such as drowsiness, constipation, and changes in heart rate. It usually takes 4-6 weeks for the drug to start working and its full effects to be seen, although the reason for this is not yet known.
How Sertraline Hydrochloride works in the bodySertraline blocks the reuptake of serotonin in the brain, which increases the amount of serotonin available to help regulate mood. This change in serotonin levels is believed to be responsible for the drug's ability to improve symptoms of depression and other anxiety disorders. In animal studies, sertraline has been shown to reduce the activity of norepinephrine receptors. It also has weak effects on the uptake of norepinephrine and dopamine, but does not affect the activity of the monoamine oxidase enzyme.
When to interrupt dosage
The suggested amount of Sertraline Hydrochloride is contingent upon the confirmed condition, comprising Social Anxiety Disorder, Obsessive-Compulsive Disorder and Post Traumatic Stress Disorder. The measure of dosage is contingent upon the approach of administration (e.g. Tablet, film coated or Concentrate) as stated in the table hereunder.Condition
Dosage
Administration
Binge Eating Disorder (BED)
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Post Traumatic Stress Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Bulimia Nervosa
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Depression
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Obsessive-Compulsive Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Generalized Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Panic Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Social Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Sertraline Hydrochloride presents five contraindications and should not be taken together with the ailments presented in the following table.Sertraline Hydrochloride ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sertraline may interact with Pulse Frequency
Common Sertraline Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of serotonin syndrome can be increased when Sertraline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sertraline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Sertraline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Sertraline.
Azelastine
Major
Sertraline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Sertraline Hydrochloride Toxicity & Overdose RiskThe toxic dose of sertraline in rats is over 2000 mg/kg, while it is 419 - 548 mg/kg in mice and 1327 - 1591mg/kg in rats. Signs and symptoms of an overdose include drowsiness, vomiting, fast heartbeat, nausea, dizziness, restlessness, and shaking. Rarely, serious medical conditions such as serotonin syndrome, high or low blood pressure, loss of consciousness, slow heartbeat, irregular heartbeat, confusion, hallucinations, and pancreatitis may occur. Fatal overdoses from sertraline alone are rare, but may occur when taken with other drugs.
Sertraline Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Sertraline Hydrochloride?
526 investigations are actively assessing the potential of Sertraline Hydrochloride to ameliorate Bulimia Nervosa, Premenstrual Dysphoric Disorder and Obsessive-Compulsive Disorder.Condition
Clinical Trials
Trial Phases
Post Traumatic Stress Disorder
253 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 3
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Binge Eating Disorder (BED)
1 Actively Recruiting
Phase 4
Generalized Anxiety Disorder
32 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Panic Disorder
17 Actively Recruiting
Not Applicable, Phase 2
Bulimia Nervosa
15 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Social Anxiety Disorder
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3
Sertraline Hydrochloride Reviews: What are patients saying about Sertraline Hydrochloride?
5Patient Review
7/3/2022 I was really stressed out and constantly worrying, but I decided to give these a try. They made me feel awful for the first week, but after that my life changed for the better. If you're in a bad place, I advise you to consider taking them and put up with the side effects for the first week.
4Patient Review
8/24/2022 My wife calls these "anti-divorce drugs" because they work so well for me. I'm really grateful to have found something that helps keep our marriage strong.
3.7Patient Review
9/10/2022 I would recommend starting with a lower dosage than what my doctor originally prescribed me. I started out at 50 mg and had to get it lowered to 25 mg because of the unpleasant side effects. However, the medication was much more effective after the two weeks of use.
3Patient Review
8/4/2022 I haven't seen much improvement since starting this medication. I'm still experiencing the same level of depression, suicidal thoughts, and lack of appetite and sleep.
2.7Patient Review
9/7/2022 I had to increase my dosage of sertraline due to worsening anxiety and depression. I was doing well on the drug in the past, but now after increasing my dosage, I feel worse. Can anyone tell me if this is normal and if the drug will eventually start working again?
2.3Patient Review
6/28/2022 I've been taking sertraline for a while now, and I have to say that I haven't seen many benefits. If anything, it's made things worse. I've gained a lot of weight, I'm constantly tired, and my mood swings are through the roof. In my opinion, this medication is not meant to be taken for long-term use.
1.7Patient Review
9/26/2022 I tried this medication for insomnia and was very disappointed. I took 25 mg the first night and could not fall asleep, then 50 mg the second night with no results. On the third night, I took 75 mg and still saw no effect whatsoever. At that point, I stopped taking the prescription entirely.I don't understand why my doctor prescribed me this depression medication for insomnia in the first place; after reading some of these reviews, I wouldn't have taken it even if she upped the dosage.
Patient Q&A Section about sertraline hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the main side effects of sertraline?
"Nausea: Try taking sertraline with or after food. Headaches: Make sure you rest and drink plenty of fluids. Insomnia: Take sertraline first thing in the morning. Sleepiness: Feel free to take naps. Diarrhea: Drink lots of fluids. Dry mouth: Suck on ice chips or sugar-free hard candy. Dizziness: Get up slowly from a lying or sitting position. Fatigue: Drink lots of fluids and get plenty of rest."
Answered by AI
Is sertraline hydrochloride a Xanax?
"There are two different brand names for alprazolam- Xanax and Niravam. Alprazolam belongs to the drug class of benzodiazepines, while sertraline- another brand name drug- is placed under the class of selective serotonin reuptake inhibitor antidepressants."
Answered by AI
Does sertraline hydrochloride make you sleep?
"The two most common side effects of sertraline (Zoloft) are fatigue and tiredness. If you're using sertraline to treat depression, the fatigue and tiredness from the medication can be compounded by the effects of depression on your mood."
Answered by AI
What is the use of sertraline hydrochloride?
"Sertraline is used to treat mental health conditions including depression, obsessive-compulsive disorder, panic attacks, and posttraumatic stress disorder."
Answered by AI