Atomoxetine Hydrochloride

Attention Deficit Hyperactivity Disorder
Treatment
1 FDA approval
20 Active Studies for Atomoxetine Hydrochloride

What is Atomoxetine Hydrochloride

AtomoxetineThe Generic name of this drug
Treatment SummaryAtomoxetine, also known as Strattera, is a medication used to treat attention deficit hyperactivity disorder (ADHD). It works by increasing the levels of norepinephrine and dopamine in the prefrontal cortex of the brain, which can improve focus and reduce impulsivity and hyperactivity. Atomoxetine is a non-stimulant medication, which makes it a good alternative to stimulant drugs like Ritalin, Adderall, and Concerta. It has fewer side effects than stimulants and has a lower potential for abuse. Atomoxetine is usually prescribed along with other treatments such as psychological therapy,
Stratterais the brand name
image of different drug pills on a surface
Atomoxetine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Strattera
Atomoxetine
2002
183

Approved as Treatment by the FDA

Atomoxetine, commonly known as Strattera, is approved by the FDA for 1 uses like Attention Deficit Hyperactivity Disorder .
Attention Deficit Hyperactivity Disorder
Helps manage Attention Deficit Hyperactivity Disorder (ADHD)

Effectiveness

How Atomoxetine Hydrochloride Affects PatientsAtomoxetine is a medication used to treat attention deficit hyperactivity disorder (ADHD). It works by increasing the levels of norepinephrine and dopamine in the brain, which improves ADHD symptoms. However, it can also affect the cardiovascular system, causing an increase in blood pressure and heart rate. Therefore, it should be used cautiously in patients with existing heart or blood vessel issues. In addition, it can cause psychotic or manic symptoms in people without a prior history of such illnesses, so if such symptoms occur the medication should be stopped. Atomoxetine can also increase the risk of suicidal thoughts in children and adolescents with ADHD.
How Atomoxetine Hydrochloride works in the bodyAtomoxetine is used to treat ADHD. It works by blocking the reuptake of norepinephrine and serotonin in the brain, which increases their availability and helps reduce symptoms of ADHD. It also affects the glutamatergic system in the brain, which is thought to play a role in ADHD.

When to interrupt dosage

The dosage of Atomoxetine Hydrochloride is contingent upon the diagnosed condition. The quantity of dosage varies, depending on the technique of administration enumerated in the table below.
Condition
Dosage
Administration
Attention Deficit Hyperactivity Disorder
, 10.0 mg, 18.0 mg, 25.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 100.0 mg
Oral, Capsule, Capsule - Oral, , Kit, Kit - Oral

Warnings

Atomoxetine Hydrochloride Contraindications
Condition
Risk Level
Notes
Cardiovascular Diseases
Do Not Combine
advanced arteriosclerosis
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pheochromocytoma
Do Not Combine
Hyperthyroidism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Atomoxetine may interact with Pulse Frequency
There are 20 known major drug interactions with Atomoxetine Hydrochloride.
Common Atomoxetine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Atomoxetine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Atomoxetine.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Atomoxetine.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Atomoxetine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Hydroxyzine.
Atomoxetine Hydrochloride Toxicity & Overdose RiskThere have been very few cases of overdose on atomoxetine. In some cases, people have died from mixing atomoxetine with other drugs, but no deaths from overdose of atomoxetine alone have been reported, even when taken in amounts of up to 1400mg. Symptoms of overdose include stomach issues, drowsiness, dizziness, trembling, hyperactivity, agitation, increased heart rate and blood pressure, dry mouth, confusion, and hallucinations. If you suspect an overdose of atomoxetine, contact a poison control center.
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Atomoxetine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Atomoxetine Hydrochloride?

At present, 77 active studies are evaluating the potential of Atomoxetine Hydrochloride to treat Attention Deficit Hyperactivity Disorder.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
63 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

Atomoxetine Hydrochloride Reviews: What are patients saying about Atomoxetine Hydrochloride?

5Patient Review
9/2/2022
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
From the very first day I took this medication, I noticed a significant difference. My thinking was more clear and focused, anxiety and negative thoughts lessened, and I felt generally more peaceful and content.
5Patient Review
2/7/2022
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
After years of struggling with anxiety and focus, this medication has completely changed my life for the better. I'm so grateful to have found a doctor that knew this would help me.
4.7Patient Review
6/13/2014
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
This treatment, in conjunction with Adderall, put me into a manic state. I found that Depakote (750mg) helped me to achieve mental balance. For anxiety, I used Tenex and supplemented it with L-theanine (from green tea). This combination made me more aware and calm, without the drowsy feeling.
4.7Patient Review
9/19/2017
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I'm feeling pretty good after taking this drug. I'm more focused and have less energy, but in a calm way. I'm sometimes sleepy, but overall it's a positive experience.
4.3Patient Review
1/19/2012
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I was really struggling with my addiction to Vyvanse, so my doctor decided to try Strattera instead. I have to say that it works better for me than any stimulant has in the past. Plus, I don't have to worry about becoming addicted to it.
4Patient Review
2/26/2021
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I found this to be much more effective than adderall or ritalin, with none of the jitters, sweating, anxiety, or mood swings. However, I find the effects to be inconsistent. Some days I feel like I haven't taken anything while others I can be a bit of a zombie, but most of the time I feel like a productive normie. Best part is its not a stimulant.
4Patient Review
8/23/2011
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
3Patient Review
11/12/2022
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I experienced no negative side effects, but unfortunately this treatment did not provide any relief for me.
3Patient Review
10/9/2012
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
It took a little bit of trial and error to get the dosage right, but this medication has been working well for me for several years now.
2.7Patient Review
10/5/2019
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
This treatment was very painful and resulted in an extremely unpleasant ejaculation.
2.3Patient Review
3/13/2022
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
As someone with ADHD, this medication just made me feel exhausted and unable to focus on anything. If I took it at night, I would be more hyperactive the next day than if I hadn't taken it at all.
2.3Patient Review
10/12/2013
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I'm concerned about the fact that this is a controlled substance.
2.3Patient Review
10/12/2013
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I found that this, alongside Adderall, put me in a manic state. I now use depakote 750mg to maintain mental balance, and for anxiety tenex. I also supplement with L-theanine (from green tea), which helps me stay calm and aware.
1.3Patient Review
11/14/2011
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
On the first day that I took Strattera, I felt like a new person. No anxiety, more organized, and able to focus on one thing at a time. My wife even said that I went from a 1 to an 8. It's amazing how this medication has changed my life and made me feel normal for the first time in 54 years.
1Patient Review
5/10/2018
Atomoxetine Hydrochloride for Attention Deficit Disorder with Hyperactivity
I had a really negative reaction to this medication. I became nauseous and jittery, and then got a headache that wouldn't go away no matter what painkillers I took. Overall, my health was negatively impacted.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about atomoxetine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does atomoxetine make you feel?

"Atomoxetine may cause fatigue and drowsiness. It may also make it difficult to fall asleep and stay asleep for some people. Additionally, some people may wake up earlier than usual in the morning and be unable to fall back asleep. If you experience any of these issues, talk to your doctor."

Answered by AI

What are side effects of atomoxetine?

"If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If you experience any of the following side effects, you should tell your doctor or pharmacist: stomach upset, nausea, vomiting, constipation, tiredness, loss of appetite/weight loss, dry mouth, dizziness, drowsiness, trouble sleeping, or decrease in sexual ability/desire. In addition, women may experience menstrual cramps or missed/irregular periods. If any of these effects persist or worsen, tell your doctor or pharmacist."

Answered by AI

What is atomoxetine Hydrochloride used for?

"Atomoxetine is a medication used to treat ADHD that increases the ability to pay attention and decreases impulsiveness and hyperactivity. Atomoxetine belongs to a class of medications called selective norepinephrine reuptake inhibitors."

Answered by AI

Is atomoxetine the same as Adderall?

"Amphetamines are central nervous system (CNS) stimulants that work by increasing levels of the neurotransmitters dopamine and norepinephrine in the brain. Strattera, on the other hand, is a norepinephrine reuptake inhibitor that also works to increase levels of dopamine and norepinephrine in the brain by preventing them from being taken up by neurons. While Strattera and Adderall are both used to treat ADHD, they are completely different drugs. Adderall is a combination of two drugs in the amphetamine class of medication. Amphetamines are central nervous system (CNS) stimulants that work by increasing levels of the neurotransmitters dopamine and norepinephrine in the brain. Strattera, on the other hand, is a norepinephrine reuptake inhibitor that also works to increase levels of dopamine and norepinephrine in the brain by preventing them from being taken up by neurons."

Answered by AI

Clinical Trials for Atomoxetine Hydrochloride

Image of St. Jude Children's Research Hospital in Memphis, United States.

Methylphenidate for Sickle Cell Disease

8 - 17
All Sexes
Memphis, TN
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any thinking or attention problems participants may have both before taking this drug and after. Additionally, the study will assess the decision-making process of the caregiver that may influence using this drug or not. Primary Objective: • Assess the feasibility, acceptability, and adherence to MPH treatment in children with SCD and EF deficits. Secondary Objective: • Evaluate neurobehavioral and safety outcomes following MPH treatment. Exploratory Objective: • Evaluate decision-making and determinants influencing methylphenidate utilization among parents.
Phase 1
Recruiting
St. Jude Children's Research HospitalAndrew Heitzer, PhD
Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of UCSF Nancy Friend Pritzker Psychiatry Building in San Francisco, United States.

Trigeminal Nerve Stimulation for ADHD in Children with Autism

7 - 14
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD). It will also learn about the efficacy and tolerability of the eTNS device. The main questions it aims to answer are: * Does eTNS reduce ADHD symptoms? * Does eTNS improve core and associated features of ASD? Participation spans 8-12 weeks and includes: * 4-5 in-person visits * 4 brief virtual check-ins * Nightly use of the eTNS device with a small sticky patch applied to child's forehead * Randomized assignment (those who start with the sham device may try the active device later)
Recruiting
Device
UCSF Nancy Friend Pritzker Psychiatry Building
Have you considered Atomoxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Atomoxetine Hydrochloride, we think they might fit your search criteria.Go to Trials
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Biofeedback and Lifestyle Interventions for ADHD

7 - 18
All Sexes
Gillette, WY
The Pediatric Healing Minds II intervention includes a biofeedback component, breathing practices nutrition and exercise counseling. Biofeedback is a type of mind-body technique used to control body functions such as heart, lung and muscle responses. Biofeedback uses therapeutic techniques that aim to help study participants gain more awareness and control over certain physiological functions in their bodies. It involves the use of electronic monitoring equipment to provide real-time information about physiological processes such as heart rate, HRV, coherence and muscle tension. This information is then provided back to the study participant, allowing them to learn how to consciously regulate these processes. During the sessions parents are expected to attend and participate. Study participants and parents will have access to a video that provides instructions for placement of the Heart Math single small ear lobe or finger sensor. Breathing Practices include alternate nostril, qi gong and other breathing practices. Nutrition counseling includes nutrition supplementation to correct deficiencies, dietary education and an age-and gender-specific diet prescription based on the Mediterranean Diet. Exercise counseling includes developmentally appropriate guidelines for cardiopulmonary, strength and flexibility activities based on guidelines from the American College of Sports Medicine (ACSM) and the American Academy of Pediatrics (AAP). The objective of this research proposal is to examine the combined effects of an integrative approach including biofeedback, breathing practices, nutrition and exercise counseling intervention (Healing Minds II), on symptoms and severity of ADHD, impulsivity and attention (e.g., QB continuous performance test) in youth 7-18 years of age. The investigators hypothesize that ADHD symptoms and severity, impulsivity and attention will be significantly improved and coherence increased after participation in the 6-month intervention. The investigators also propose that ADHD severity in those patients with prescribed medication but poorly-controlled ADHD will demonstrate the greatest improvement compared to those not prescribed medication and those who have well-controlled ADHD.
Waitlist Available
Has No Placebo
Hoskinson Health and Wellness ClinicInara McMaster, MDHoskinson Health and Wellness Clinic
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Virtual Reality for ADHD

18 - 25
All Sexes
Baton Rouge, LA
The goal of this larger parallel group randomized trial is to test the impact of a virtual reality program for improving the ability of emerging adults (age 18-25) with attention deficit hyperactivity disorder (ADHD) to stay focused while completing homework and studying. This study compares the impact of using a virtual reality headset to using a virtual reality headset while also receiving feedback about levels of focus to a control group. The main question is whether participants demonstrate significantly improved concentration while completing homework and studying in virtual reality and whether they enjoy and prefer working in a virtual reality environment. Concentration is measured both through participant report and also using keyboard and mouse click data to assess work productivity objectively.
Phase 4
Waitlist Available
Louisiana State University (+1 Sites)Joshua M Langberg, PhD
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Organizational Skills Training vs Mindfulness for ADHD

13 - 17
All Sexes
Durham, NC
This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program. Both treatments are eight 90 minute sessions. The research component will involve a pre-treatment assessment and post-treatment assessment. Both assessments will involve adolescents and one caregiver to complete questionnaires over REDCap. Rating scales will include ADHD symptom severity (Conners 3: self and parent report), functional impairment (IRS: self and parent report), executive functioning (BRIEF-2: parent report), emotion dysregulation (DERS: self and parent report), trait mindfulness (FFMQ: self report), organizational skills (BRIEF-2: parent report), treatment satisfaction (self report and parent report) and credibility (self report and parent report). Post-treatment assessments for feasibility will include attendance (measured over the course of treatment) and homework completion rates on a scale of 1 to 5 in which 5 indicates higher homework completion. We will also assess acceptability via individual items on a Likert scale (self report): overall satisfaction, how much was learned about ADHD, usefulness of information learned, content relevance to individual experience, comprehension of strategies, confidence about using strategies, likelihood of using strategies, helpfulness to share with the group, benefits from hearing from other group members, willingness to recommend the same treatment to others, and whether or not treatment was beneficial.
Recruiting
Has No Placebo
Duke UniversityJohn Mitchell, PhD
Have you considered Atomoxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Atomoxetine Hydrochloride, we think they might fit your search criteria.Go to Trials
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Speech-Gesture Combinations for Autism

Any Age
All Sexes
Bozeman, MT
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are especially disadvantaged by the lack of accessible services in their rural communities. Individuals with other cognitive profiles, including Developmental Language Disorder (DLD), ADHD, Dyslexia, and others are welcome too. The study uses methods of eye tracking and recording of brain activity to understand how hand gestures adapted from signs from American Sign Language, such as \[cry\], can promote successful understanding of words like "cry". The overarching goal is to help families effectively utilize gestures to support communication with their children.
Recruiting
Has No Placebo
Montana State University
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Measurement Feedback App for Autism Spectrum Disorder

18+
All Sexes
Philadelphia, PA
The goal of this clinical trial is to test whether a smartphone-based data collection and feedback application ("Footsteps") improves the quality of behavioral data collected by one-to-one aides and leads to better youth mental health outcomes in school-aged youth (ages 4-17) who receive one-to-one support in schools. The main questions it aims to answer are: 1. Does the Footsteps app improve aides' data collection quality (i.e., consistency, timeliness, and completeness)? 2. Does Footsteps use lead to improved youth behavioral health outcomes (e.g., SDQ, YTP, GAS scores)? 3. Does Footsteps improve communication and supervision processes between aides and clinical supervisors? Researchers will compare aides using Footsteps to those using a "data collection only" control app to see if Footsteps leads to higher quality data collection, enhanced supervisory communication, and better youth outcomes. Participants will: * Use either Footsteps or a control app to record de-identified data on one client's behaviors and skills over 12 weeks * Complete biweekly online surveys about data collection experiences, youth progress, and aide-supervisor communication * Participate in a virtual intake and post-trial meeting * (For a subset) Participate in a 30-45 minute qualitative interview about their experience using the app
Waitlist Available
Has No Placebo
University of PennsylvaniaHeather J Nuske, PhD
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Guided Deep Breathing for ADHD

7 - 11
All Sexes
Brookline, MA
Attention-deficit/hyperactivity disorder (ADHD) affects approximately 11% of children and adolescents in the United States. Individuals with ADHD experience substantial impairments and burdens across multiple areas of daily living, including peer difficulties, academic difficulties, poor job outcomes, high rates of co-occurring disorders, and large financial costs. Although there are many well-established, evidence-based treatments for ADHD, many children continue to experience significant impairment and elevated ADHD symptoms even with prolonged treatment. Further, there are several limitations to existing treatment approaches, including medication side effects, difficulty accessing behavioral treatments, and high out-of-pocket costs for behavioral treatments. Thus, there is a crucial need to identify low cost, low burden, alternative or additive intervention approaches for pediatric ADHD. In the current pilot study, we aim to evaluate responses in behavioral and brain-based markers of attention to a mindfulness-based intervention. Mindfulness-based interventions (MBIs), including deep breathing, have received considerable research attention regarding their benefits for ADHD symptoms. Deep breathing is a strong candidate as a supplementary MBI intervention for children with ADHD due to its simplistic and easy-to-implement nature. Studies examining the effects of deep breathing on physiological arousal and ADHD symptoms in children have yielded promising results. Children will be led through a brief deep breathing intervention using a novel tool designed to optimize child engagement in deep breathing. This tool, Domi, is designed to be held in the child's hands and uses a series of haptic vibrations to provide real-time deep breathing pacing guidance. We predict that following a brief deep breathing practice, children with ADHD will demonstrate improved sustained attention, reaction time consistency, and inhibitory control. These areas of attention and behavioral functioning will be assessed using computer tasks and measures of brain activity. We plan to use the results of this study to strengthen a future application for grant funding to run a similar trial with many more children. We believe that the results of this and future studies will improve the lives of children with ADHD and their families.
Waitlist Available
Has No Placebo
Boston Children's Hospital Laboratories of Cognitive Neuroscience
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MomMA Intervention for ADHD

18+
Female
Pittsburgh, PA
The goal of this study is to test a behavioral program for pregnant individuals with ADHD. This behavioral program focuses on skills for managing ADHD and related symptoms in pregnancy and postpartum. This pilot effectiveness-implementation trial aims to (1) preliminarily evaluate the MomMA behavioral intervention compared to treatment as usual (TAU) on clinical outcomes and (2) evaluate implementation outcomes, including feasibility and acceptability of clinic screening within existing OB workflows; assessment and intervention protocols; provider training/fidelity to manual; and all other study protocols from the perspective of real-world providers and participants.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalHeather M Joseph, DO Assistant Professor of Psychiatry and Pediatrics
Have you considered Atomoxetine Hydrochloride clinical trials? We made a collection of clinical trials featuring Atomoxetine Hydrochloride, we think they might fit your search criteria.Go to Trials
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