Reserpine
Hypertensive disease
Treatment
1 FDA approval
20 Active Studies for Reserpine
Treatment for
Hypertensive disease
What is Reserpine
Reserpine
The Generic name of this drug
Treatment Summary
Reserpine is a type of alkaloid found in two plants, Rauwolfia serpentina and R. vomitoria. It works by blocking the uptake of norepinephrine into storage vesicles, which leads to a decrease of catecholamines and serotonin in the body. It has been used to treat high blood pressure and certain mental health conditions, but its side effects limit its use in clinical settings.
Ser-Ap-Es
is the brand name
Reserpine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ser-Ap-Es
Reserpine
1960
8
Approved as Treatment by the FDA
Reserpine, also called Ser-Ap-Es, is approved by the FDA for 1 uses like Hypertensive disease .
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Polythiazide
Effectiveness
How Reserpine Affects Patients
Reserpine is a drug used to lower blood pressure by blocking substances (norepinephrine) that control the rate of your heart, the force of your heart's contractions, and the amount of resistance in your blood vessels. It does this by preventing these substances from being stored in nerve endings.
How Reserpine works in the body
Reserpine stops the body from storing neurotransmitters in presynaptic neurons. This prevents the neurotransmitters from being available to be used, and they are instead broken down by an enzyme called monoamine oxidase. This reduces the amount of catecholamines in the body.
When to interrupt dosage
The suggested quantity of Reserpine is contingent upon the diagnosed condition. The dosage fluctuates as per the delivery method outlined in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
, 0.1 mg, 0.25 mg, 0.125 mg, 25.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
There are 20 known major drug interactions with Reserpine.
Common Reserpine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Reserpine.
Amifostine
Major
Reserpine may increase the hypotensive activities of Amifostine.
Amisulpride
Major
Reserpine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be increased when combined with Reserpine.
Axitinib
Major
The serum concentration of Axitinib can be increased when it is combined with Reserpine.
Reserpine Toxicity & Overdose Risk
This drug has the potential to cause cancer in humans. It may also harm reproductive health. Tests have shown that when given orally to rats, the lethal dose is 420mg/kg, when given intravenously it is 15mg/kg, and when given to mice, it is 200mg/kg and 52mg/kg respectively. When given by injection to rabbits, the lethal dose is 7mg/kg.
Reserpine Novel Uses: Which Conditions Have a Clinical Trial Featuring Reserpine?
18 active trials are currently underway to assess the utility of Reserpine for the treatment of Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
30 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Reserpine Reviews: What are patients saying about Reserpine?
5
Patient Review
3/10/2012
Reserpine for High Blood Pressure
5
Patient Review
6/9/2010
Reserpine for Severe Mental Disorder with Loss of Personality & Reality
4.3
Patient Review
6/25/2009
Reserpine for High Blood Pressure
Patient Q&A Section about reserpine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the drug reserpine used for?
"Reserpine is a medication used to lower blood pressure, treat psychiatric disorders, and tardive dyskinesia. It is available as the brand name Serpasil."
Answered by AI
Why reserpine is not used clinically?
"Reserpine was approved for use in the United States in 1955. However, it is currently not often used because it can cause central nervous system effects and there are many other antihypertensive medications that are more tolerated and more potent."
Answered by AI
What is reserpine mechanism of action?
"Reserpine irreversibly blocks the vesicular monoamine transporter-2 (VMAT-2), which is involved in adrenergic neurotransmission. This blockage prevents serotonin, norepinephrine, and dopamine from being taken up into presynaptic storage vesicles."
Answered by AI
Where is reserpine found?
"In the 1950s the Indian scientist K.C. Appa and his colleagues showed that reserpine, the principal alkaloid of the root, was the active ingredient in treating high blood pressure
Reserpine is a drug that comes from the roots of certain tropical plants in the Rauwolfia species. In the past, the powdered root of the Indian shrub Rauwolfia serpentina was used to treat snakebites, insomnia, and high blood pressure. In the 1950s, Indian scientist K.C. Appa and his colleagues discovered that reserpine, the main alkaloid in the root, was what was actually effective in treating high blood pressure."
Answered by AI