Reserpine

Hypertensive disease

Treatment

1 FDA approval

20 Active Studies for Reserpine

Treatment for

Hypertensive disease

What is Reserpine

ReserpineThe Generic name of this drug

Treatment SummaryReserpine is a type of alkaloid found in two plants, Rauwolfia serpentina and R. vomitoria. It works by blocking the uptake of norepinephrine into storage vesicles, which leads to a decrease of catecholamines and serotonin in the body. It has been used to treat high blood pressure and certain mental health conditions, but its side effects limit its use in clinical settings.

Ser-Ap-Esis the brand name

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Reserpine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ser-Ap-Es

Reserpine

1960

Approved as Treatment by the FDA

Reserpine, also called Ser-Ap-Es, is approved by the FDA for 1 uses like Hypertensive disease .

Hypertensive disease

Used to treat High Blood Pressure (Hypertension) in combination with Polythiazide

Effectiveness

How Reserpine Affects PatientsReserpine is a drug used to lower blood pressure by blocking substances (norepinephrine) that control the rate of your heart, the force of your heart's contractions, and the amount of resistance in your blood vessels. It does this by preventing these substances from being stored in nerve endings.

How Reserpine works in the bodyReserpine stops the body from storing neurotransmitters in presynaptic neurons. This prevents the neurotransmitters from being available to be used, and they are instead broken down by an enzyme called monoamine oxidase. This reduces the amount of catecholamines in the body.

When to interrupt dosage

The suggested quantity of Reserpine is contingent upon the diagnosed condition. The dosage fluctuates as per the delivery method outlined in the table beneath.

Condition

Dosage

Administration

Hypertensive disease

, 0.1 mg, 0.25 mg, 0.125 mg, 25.0 mg

, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

There are 20 known major drug interactions with Reserpine.

Common Reserpine Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Reserpine.

Amifostine

Major

Reserpine may increase the hypotensive activities of Amifostine.

Amisulpride

Major

Reserpine may increase the antipsychotic activities of Amisulpride.

Astemizole

Major

The metabolism of Astemizole can be increased when combined with Reserpine.

Axitinib

Major

The serum concentration of Axitinib can be increased when it is combined with Reserpine.

Reserpine Toxicity & Overdose RiskThis drug has the potential to cause cancer in humans. It may also harm reproductive health. Tests have shown that when given orally to rats, the lethal dose is 420mg/kg, when given intravenously it is 15mg/kg, and when given to mice, it is 200mg/kg and 52mg/kg respectively. When given by injection to rabbits, the lethal dose is 7mg/kg.

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Reserpine Novel Uses: Which Conditions Have a Clinical Trial Featuring Reserpine?

18 active trials are currently underway to assess the utility of Reserpine for the treatment of Hypertensive disease.

Condition

Clinical Trials

Trial Phases

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Reserpine Reviews: What are patients saying about Reserpine?

5Patient Review

3/10/2012

Reserpine for High Blood Pressure

I've been using this medication for 30 years now and it's still working great with no side effects!

5Patient Review

6/9/2010

Reserpine for Severe Mental Disorder with Loss of Personality & Reality

This treatment is amazing. I'm grateful for modern medicine.

4.3Patient Review

6/25/2009

Reserpine for High Blood Pressure

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Patient Q&A Section about reserpine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug reserpine used for?

"Reserpine is a medication used to lower blood pressure, treat psychiatric disorders, and tardive dyskinesia. It is available as the brand name Serpasil."

Answered by AI

Why reserpine is not used clinically?

"Reserpine was approved for use in the United States in 1955. However, it is currently not often used because it can cause central nervous system effects and there are many other antihypertensive medications that are more tolerated and more potent."

Answered by AI

What is reserpine mechanism of action?

"Reserpine irreversibly blocks the vesicular monoamine transporter-2 (VMAT-2), which is involved in adrenergic neurotransmission. This blockage prevents serotonin, norepinephrine, and dopamine from being taken up into presynaptic storage vesicles."

Answered by AI

Where is reserpine found?

"In the 1950s the Indian scientist K.C. Appa and his colleagues showed that reserpine, the principal alkaloid of the root, was the active ingredient in treating high blood pressure

Reserpine is a drug that comes from the roots of certain tropical plants in the Rauwolfia species. In the past, the powdered root of the Indian shrub Rauwolfia serpentina was used to treat snakebites, insomnia, and high blood pressure. In the 1950s, Indian scientist K.C. Appa and his colleagues discovered that reserpine, the main alkaloid in the root, was what was actually effective in treating high blood pressure."

Answered by AI

Clinical Trials for Reserpine

Have you considered Reserpine clinical trials? We made a collection of clinical trials featuring Reserpine, we think they might fit your search criteria.

Have you considered Reserpine clinical trials? We made a collection of clinical trials featuring Reserpine, we think they might fit your search criteria.