Dyazide

Nephrotic Syndrome, Edema, Swollen feet or ankles + 8 more
Treatment
20 Active Studies for Dyazide

What is Dyazide

TriamtereneThe Generic name of this drug
Treatment SummaryTriamterene is a medication used to treat high blood pressure. It works by promoting the excretion of sodium and water from the body while helping to retain potassium. High levels of potassium can be dangerous, so triamterene needs to be carefully monitored when prescribed. Triamterene is sometimes used with other diuretics to enhance their effects and can also be found in combination with hydrochlorothiazide for treating edema and hypertension. It was approved by the FDA in 1964 and is generally considered safe and effective.
Maxzideis the brand name
image of different drug pills on a surface
Dyazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxzide
Triamterene
1988
188

Effectiveness

How Dyazide Affects PatientsTriamterene is a medication used to lower blood pressure and reduce swelling. It works in the kidneys by not allowing sodium and magnesium to be reabsorbed, and instead promotes the excretion of potassium. This can lead to an increase in potassium levels that can cause irregular heartbeats. In clinical trials, triamterene was found to be more effective when taken with hydrochlorothiazide in lowering blood pressure. It does not affect calcium excretion.
How Dyazide works in the bodyTriamterene is a diuretic drug that helps reduce sodium absorption in the late distal tubule of the kidney. It works by blocking sodium channels, which limits the amount of sodium that can be reabsorbed into the body. It also helps reduce loss of potassium, hydrogen, and chloride ions. Triamterene increases urine output and decreases sodium, potassium, and magnesium levels in the body.

When to interrupt dosage

The portion of Dyazide is contingent upon the identified disorder, including Cirrhosis, Hypokalemia and Edema. The exact dosage is contingent upon the approach of delivery (e.g. Capsule or Tablet - Oral) described in the table hereunder.
Condition
Dosage
Administration
Cirrhosis
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diuretics
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypokalemia
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Swollen feet or ankles
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Nephrotic Syndrome
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Thiazides
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Warnings

Dyazide has five contraindications, and thus should not be administered when suffering from the conditions in the following table.Dyazide Contraindications
Condition
Risk Level
Notes
severe progressive kidney disease
Do Not Combine
elevated serum potassium levels
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Liver diseases
Do Not Combine
There are 20 known major drug interactions with Dyazide.
Common Dyazide Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Neomycin.
Tacrolimus
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Tenofovir
Major
Triamterene may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Triamterene may increase the nephrotoxic activities of Tenofovir alafenamide.
Dyazide Toxicity & Overdose RiskAn overdose of triamterene can be dangerous, causing symptoms such as nausea, vomiting, weakness, and low blood pressure. These symptoms are due to an imbalance of electrolytes, such as an increase of potassium. To treat an overdose, vomiting and stomach pumping should be done right away. Doctors may also monitor electrolyte levels and fluid balance. Dialysis may be able to help remove the drug from the body. Long-term studies in mice suggest that triamterene can cause liver tumors, but it is not known if this is true in humans. Also, triamterene has not been tested to see
image of a doctor in a lab doing drug, clinical research

Dyazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Dyazide?

138 active studies are currently assessing the effectiveness of Dyazide in managing Cirrhosis, Hypokalemia and Nephrotic Syndrome.
Condition
Clinical Trials
Trial Phases
Nephrotic Syndrome
10 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Cirrhosis
52 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Diuretics
0 Actively Recruiting
Edema
0 Actively Recruiting
Congestive Heart Failure
21 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Thiazides
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypokalemia
0 Actively Recruiting

Dyazide Reviews: What are patients saying about Dyazide?

4.7Patient Review
4/23/2018
Dyazide for Visible Water Retention
I've been taking this medication for a few years to help with water retention and it's done a great job. Recently though, I've started experiencing dry mouth and dizziness.
4.7Patient Review
8/25/2017
Dyazide for High Blood Pressure
I use this medication for my blood pressure and I've already noticed some great results. My shortness of breath has decreased, and the swelling in my ankles from amlodipine is gone.
4.7Patient Review
4/23/2018
Dyazide for Visible Water Retention
I've been taking this medication for a while now and it's done wonders in reducing the water retention in my legs and ankles. Recently though, I've started to experience dry mouth and dizziness.
4.7Patient Review
8/25/2017
Dyazide for High Blood Pressure
I use this for my blood pressure and I saw an immediate difference. Not only did my shortness of breath go away, but the swelling in my ankles from amlodipine disappeared as well. I was hesitant to try this treatment at first, but I'm glad I did.
4.3Patient Review
12/23/2016
Dyazide for High Blood Pressure
4.3Patient Review
12/23/2016
Dyazide for High Blood Pressure
4Patient Review
6/4/2021
Dyazide for High Blood Pressure
I haven't tried this treatment yet, but I'm excited to.
4Patient Review
7/23/2017
Dyazide for Visible Water Retention
I've noticed that my pharmacy has given me three different types of Triamterene-HCTZ 37.5-25MG recently. One is a yellow/green cap, one is a white/black cap, and one is a green tablet. I'm wondering if these medications are the same?
4Patient Review
4/17/2019
Dyazide for High Blood Pressure
I've been on this medication for a little over a week now. The swelling in my feet and legs has gone down, but the pain in my back and hips is getting worse every day.
4Patient Review
4/17/2019
Dyazide for High Blood Pressure
After a week of taking this medication, the swelling in my feet and legs has gone down. However, I am now experiencing more pain in my back and hips.
4Patient Review
7/23/2017
Dyazide for Visible Water Retention
I've gotten three different types of Triamterene-HCTZ 37.5-25MG from my pharmacy before and I'm not sure if they're supposed to be different colors/caps. Are these medications the same?
4Patient Review
6/4/2021
Dyazide for High Blood Pressure
NA
3.7Patient Review
6/5/2018
Dyazide for High Blood Pressure
While this medication has been helpful in some ways, the side effects are becoming increasingly problematic. In recent years, I've experienced severe itching and swelling on my face and scalp, hair loss, and joint pain that gets worse when exposed to sunlight.
3.7Patient Review
6/5/2018
Dyazide for High Blood Pressure
Unfortunately, this medication has some pretty severe side effects for me. It's caused a lot of itching and inflammation on my face and scalp, as well as thinning hair and bald spots. My joints have also been really painful and sensitive to sunlight. Every year, the symptoms seem to get worse.
3.7Patient Review
7/18/2016
Dyazide for Visible Water Retention
3.7Patient Review
7/18/2016
Dyazide for Visible Water Retention
3Patient Review
11/30/2020
Dyazide for High Blood Pressure
I felt dizzy and my joints were in a lot of pain.
3Patient Review
11/30/2020
Dyazide for High Blood Pressure
I felt very dizzy after taking this medication, and my joint pain was significantly worse.
2.3Patient Review
8/28/2018
Dyazide for High Blood Pressure
I was placed on this medication by my doctor twice, in order to increase the effectiveness of Benicar. However, within a month I was so exhausted that all I could do was lay down, and my muscles were incredibly weak. My blood pressure may have lowered while on the medication, but it wasn't worth the cost of how terrible I felt. Thankfully, I found the DASH diet soon after and withdrew from this medication over the course of a week. Within two weeks following withdrawal, my energy had come back, my muscles had returned to normal strength, and thanks to the DASH diet and daily exercise my blood pressure has stayed
2.3Patient Review
2/22/2022
Dyazide for Visible Water Retention
I started taking this medication a few years ago to help with water retention. I noticed that it helped somewhat, but I also began experiencing cramps in my legs, especially at night. At first, I blamed the cramps on not getting enough circulation from sitting in the car so much (I drove 60k miles per year). So, I started stopping more often to walk around, but that didn't help and the cramping has been gradually getting worse. Today my doctor took me off of the medication and believes that it is causing the cramping. We'll see if there's improvement soon.
2.3Patient Review
8/28/2018
Dyazide for High Blood Pressure
I was prescribed this medication by my doctor to help with my blood pressure. Both times I tried it, I found myself incredibly fatigued and my muscles weak. My BP did lower, but it wasn't worth the cost of how I felt. Thankfully, going on the DASH diet and withdrawing from this medication helped me immensely. Within two weeks I had all my energy back and started feeling great again.
2.3Patient Review
2/22/2022
Dyazide for Visible Water Retention
I began taking this medication a few years ago to help with water retention. While it did help somewhat, I started noticing cramping in my legs, especially at night. This gradually got worse and began happening in my arms as well. Today, my doctor took me off the medication and believes that it is the cause of the cramping. We'll see if this is true soon enough.
2.3Patient Review
9/7/2017
Dyazide for Visible Water Retention
I didn't experience any benefits from this medication.
2.3Patient Review
9/7/2017
Dyazide for Visible Water Retention
I didn't see any benefits from taking this drug.
2Patient Review
5/6/2021
Dyazide for High Blood Pressure
I've been on this medication for a few months now and have yet to see any benefits. No change in blood pressure or shortness of breath when climbing. I don't feel any different taking this medication, which is frustrating because my doctor put me on it expecting some sort of positive result.
2Patient Review
5/6/2021
Dyazide for High Blood Pressure
I have been taking this medication for about 4 months now and I see no change. My blood pressure remains at 130/85, I never had feet swelling, the medication does not make me dizzier or feel ill. The only reason my doctor put me on this was because of shortness of breath when climbing, but thus med has not changed that.
1.7Patient Review
5/13/2017
Dyazide for Visible Water Retention
I used this treatment for nearly six months in an effort to reduce the swelling in my ankles. While it did have that effect, I found myself feeling fatigued and impotent as a result. I'll be discussing other options with my doctor.
1.7Patient Review
5/13/2017
Dyazide for Visible Water Retention
I used this treatment for nearly half a year. While it did help reduce the swelling in my ankles, unfortunately it also caused me to feel fatigue and impotence. I'll be discussing with my doctor to see if there's something else out there that might work better for me.
1.3Patient Review
2/26/2017
Dyazide for Visible Water Retention
After taking this medication for four days, I found that I was waking up several times during the night to use the restroom. This drug also caused me to wet the bed on two occasions. As a result, I only take this drug once or twice a week at most and am actively searching for an alternative solution to my swollen ankles.
1.3Patient Review
2/26/2017
Dyazide for Visible Water Retention
I've been taking this for four days and it's just made me wake up all night to run to the bathroom. I'm extremely exhausted and have wet the bed twice. I refuse to take this more than twice a week because it's just not worth it.
1Patient Review
5/27/2021
Dyazide for High Blood Pressure
The only thing this medication did well was lower my blood pressure, but it came with a range of other awful side effects like nausea and gout. I would not recommend it to anyone.
1Patient Review
5/27/2021
Dyazide for High Blood Pressure
The side effects were really unpleasant and honestly outweighed any benefits for me. I wouldn't recommend it.
1Patient Review
2/14/2018
Dyazide for High Blood Pressure
Diarrhea was absolutely awful while on this medication, to the point where I had to stop taking it. It did help with swelling in my ankles, but my blood pressure remained high.
1Patient Review
2/14/2018
Dyazide for High Blood Pressure
The diarrhea this medication caused was unbearable, and it only improved my swelling marginally. I would not recommend it.

Patient Q&A Section about dyazide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the pill Dyazide used for?

"This drug is a combination of two diuretics, triamterene and hydrochlorothiazide, which are used to lower blood pressure to prevent strokes, heart attacks, and kidney problems."

Answered by AI

What are side effects of Dyazide?

"There are a variety of possible side effects that come with this medication, such as nausea, diarrhea, constipation, blurred vision, and a dry mouth. In rarer cases, you may experience a skin rash."

Answered by AI

Is Dyazide a good diuretic?

"Dyazide is a diuretic that is used to treat high blood pressure and swelling. It is a 2-in-1 diuretic that combines hydrochlorothiazide and triamterene. It is helpful for people who need to take hydrochlorothiazide and have low potassium levels."

Answered by AI

What class of drug is Dyazide?

"Dyazide is a type of diuretic drug which works by causing the kidneys to get rid of sodium and water while holding on to potassium."

Answered by AI

Clinical Trials for Dyazide

Have you considered Dyazide clinical trials? We made a collection of clinical trials featuring Dyazide, we think they might fit your search criteria.
Have you considered Dyazide clinical trials? We made a collection of clinical trials featuring Dyazide, we think they might fit your search criteria.
Have you considered Dyazide clinical trials? We made a collection of clinical trials featuring Dyazide, we think they might fit your search criteria.