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Allodepleted T Cells for Leukemia (CASPALLO Trial)
CASPALLO Trial Summary
This trial is testing a way to treat GvHD using a new drug. Patients will be given the drug as part of their stem cell transplant treatment.
CASPALLO Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCASPALLO Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CASPALLO Trial Design
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Who is running the clinical trial?
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- I don't have a closely matched donor or my disease is worsening too quickly.My transplant shows at least 50% donor cells, or my original disease has returned.My kidney function is not severely impaired.I have graft-versus-host disease.I am 65 or younger with advanced leukemia or lymphoma that has not responded to treatment.I have a condition related to an overactive immune response, such as HLH or a related disorder.I can do most activities but may need help.My liver functions are within normal limits.You have taken any experimental drugs within the last 30 days.I do not have a severe ongoing infection.My AML has returned after treatment or did not respond to initial treatment.I have been diagnosed with Myelodysplastic syndrome.I have chronic myeloid leukemia (CML).
- Group 1: Dose Level 1-3
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What safety concerns should be taken into consideration when utilizing Allodepleted T Cells?
"The safety of allodepleted T Cells is tentatively rated as a 1 due to the limited amount of data collected during Phase 1 trials, which can provide some insight into efficacy but only preliminary evidence regarding safety."
Is it still possible to join the experiment of this clinical trial?
"clinicaltrials.gov states that this research is not taking on any additional patients at the moment, despite having been initially posted in 2008 and edited as recently as July 22nd 2022. Despite this particular study's lack of recruitment opportunities, there are still 3111 other ongoing trials accepting volunteers presently."
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