Ketogenic Diet for Kidney Disease
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you must not have changed medications in the last three months to be eligible.
What data supports the effectiveness of the treatment Ketogenic Diet, High Fat, Low Carb Diet for kidney disease?
The study on the ketogenic diet for CKD patients aims to explore its impact on weight loss and metabolic changes, which could indirectly benefit kidney health by reducing obesity-related stress on the kidneys. While direct evidence for kidney disease is limited, the ketogenic diet has shown effectiveness in weight loss and metabolic improvements in other conditions, which may suggest potential benefits for CKD patients.12345
Is the ketogenic diet safe for people with kidney disease?
Research suggests that a very low-calorie ketogenic diet can be safe for weight loss in people with obesity and mild kidney failure when supervised by healthcare professionals, showing no significant harm to kidney function. However, there are reports of potential complications like hypercalcemia (high calcium levels in the blood) in children using the ketogenic diet, indicating the need for careful monitoring.13678
How is the ketogenic diet treatment different from other treatments for kidney disease?
The ketogenic diet is unique for kidney disease as it focuses on high fat and low carbohydrate intake, which is different from the typical low-protein diets often recommended for kidney health. This diet is being studied for its potential benefits in weight loss and metabolic changes in patients with mild-to-moderate chronic kidney disease and obesity, which is not a common focus of traditional kidney disease treatments.19101112
What is the purpose of this trial?
This is a prospective study to determine ketogenic diet effect on htTKV, GFR, microalbuminuria. This is a single-center study of 20 patients with ADPKD and deemed high risk for progression to ESRD. This determined by combination of features of ADPKD and htTKV as assessed by prior computed tomography (CT) or MRI. Patients will be recruited from the Polycystic Kidney Disease (PKD) Clinic at Ohio State University Wexner Medical Center. Enrolled patients will have MRI for htTKV, urinary studies, blood tests at baseline, 6 months, and 52 weeks. Blood for GFR will be assessed three times over the course of the study including baseline, 6 months, and 1 year. Participants will follow ketogenic diet for 52 weeks. Investigatory diet team will manage the ketogenic diet.
Eligibility Criteria
This trial is for adults aged 18-65 with Polycystic Kidney Disease at high risk of kidney failure, specifically those classified as Mayo Class 1C-1E. Participants should be able to follow a ketogenic diet and have stable medication use for the last three months. They must also have a GFR (a measure of kidney function) of at least 25 mg/dl.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants follow a ketogenic diet for 52 weeks with monitoring of htTKV, GFR, and microalbuminuria
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Ketogenic Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor