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CD70-Targeted CAR T-cell Therapy for Cancer
Study Summary
This trial is testing a new cancer therapy in which a person's white blood cells are modified with anti-CD70 before being given back to the person. The aim is to see if this can safely shrink tumors.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have up to 3 small, symptom-free brain tumors or have had brain surgery.I am between 18 and 72 years old.I am fully active or restricted in physically strenuous activity but can do light work.You do not have hepatitis B or C. If you test positive for hepatitis C, you need to have another test to make sure the virus is not in your blood.Your total bilirubin level is less than 2.0 mg/dL, unless you have Gilbert's Syndrome, in which case it should be less than 3.0 mg/dL.Participants must be enrolled in a specific cell harvest protocol alongside this study.I am currently on systemic steroid therapy.My cancer cannot be removed by surgery and tests show it has a high level of CD70.My cancer is visible on scans, can't be surgically removed, and tests high for CD70.I have an autoimmune disease that needs treatment to suppress my immune system.You've had a serious allergic reaction to cyclophosphamide, fludarabine, or aldesleukin in the past.I do not have any active infections, bleeding disorders, or major illnesses that are not under control.I have finished all my previous cancer treatments.I do not have any current infections that could weaken my immune system.You are currently taking any other experimental medications.My white blood cell count is healthy without needing medication.I have had heart surgery or symptoms of reduced blood flow to my heart.If you have a history of heart problems and your heart's ability to pump blood is less than or equal to 45%.My hemoglobin level is above 8.0 g/dL, possibly after a transfusion.Your platelet count should be 80,000/mm(3) or more.Your white blood cell count is 2500/mm(3) or higher.If you have a history of lung problems and your FEV1 test shows that your lung function is less than 50% of what is expected for someone your age and size, you may not be able to participate.Your cancer diagnosis needs to be confirmed by the NCI Laboratory of Pathology.I have a primary immunodeficiency disorder.I have tried at least one standard cancer treatment and it did not work or my cancer came back.I agree to use birth control during and for four months after the study.You do not have HIV, a virus that affects the immune system. This is because the experimental treatment works best in people with a strong immune system.Your liver enzymes (ALT/AST) levels in the blood are within a certain range.Your blood creatinine level is less than or equal to 1.6 mg/dL.
- Group 1: 2/Phase II
- Group 2: 1/Phase I
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any opportunities still available to join this clinical experiment?
"According to clinicaltrials.gov, this research project is actively looking for participants; it was initially published on the 6th of April 2017 and last revised on 16th November 2022."
What ailments can be aided by Anti-hCD70 CAR transduced PBL?
"Anti-hCD70 CAR transduced PBL is a cutting edge therapy used to treat multiple sclerosis. It also has potential efficacy in treating leukemia, myelocytic, acute, retinoblastoma and histiocytic lymphoma cases."
Could I potentially be a participant in this research endeavor?
"To meet the eligibility requirements for this trial, individuals must have been diagnosed with breast cancer and should be within an 18 to 70 year old age bracket. The total number of participants needed is 124."
Have any other investigations been conducted on Anti-hCD70 CAR augmented peripheral blood leukocytes?
"Presently, there are 913 active clinical trials exploring the therapeutic potential of Anti-hCD70 CAR transduced PBL. Of these studies, 163 have reached Phase 3 status. While most are based in Philadelphia, Pennsylvania, 28673 locations across the world conduct research on this topic."
Is this research encompassing participants over thirty years of age?
"Anyone aged 18-70 is eligible to apply for this trial. Moreover, there are 448 medical studies available for those under the age of consent and 3628 trials open to seniors over 65 years old."
How many participants are taking part in this clinical experiment?
"Affirmative. Clinicaltrials.gov provides evidence that the medical investigation originally posted on April 6th 2017 is actively recruiting participants, with 124 volunteers required from a single site. The data was last updated November 16th 2022."
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