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Imaging Techniques for Multiple Sclerosis
Phase 2
Waitlist Available
Led By Burcu Zeydan, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 days
Awards & highlights
Study Summary
This trial tests if MRI + PET/CT scans can help diagnose MS & measure brain inflammation related to it.
Who is the study for?
This trial is for individuals with Multiple Sclerosis (MS) who are already part of certain MS studies or clinics, and healthy controls without inflammatory brain diseases. Participants must be able to lie still for imaging procedures and give consent. Pregnant or breastfeeding women, recent steroid users, and those with MRI safety risks like pacemakers can't join.Check my eligibility
What is being tested?
The study is testing the effectiveness of combining MRI scans with PET/CT imaging using C-11 ER176 Radiotracer and C11 Pittsburgh Compound B to measure brain inflammation in people with MS.See study design
What are the potential side effects?
While not explicitly listed, potential side effects may include discomfort from lying still during imaging, allergic reactions to radiotracers, and exposure to radiation from PET/CT scans.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Uptake of C-11 ER176 Radiotracer
Uptake of C-11 Pittsburgh compound-B (PiB) in white matter myelin
Secondary outcome measures
Number of subjects with adverse events
Trial Design
2Treatment groups
Experimental Treatment
Group I: Multiple Sclerosis GroupExperimental Treatment4 Interventions
Subjects with current diagnosis of Multiple Sclerosis or an InflammatoryDemyelinating Disease of the Central Nervous System will have a PET/CT scan with radiotracer drug C-11 PIB & C-11 ER176
Group II: Healthy Control GroupExperimental Treatment4 Interventions
Subjects without inflammatory-demyelinating diseases of the central nervous system
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI
2009
Completed Phase 2
~1370
PET/CT scan
2013
Completed Phase 1
~340
Find a Location
Who is running the clinical trial?
Mayo ClinicLead Sponsor
3,207 Previous Clinical Trials
3,766,940 Total Patients Enrolled
11 Trials studying Multiple Sclerosis
2,039 Patients Enrolled for Multiple Sclerosis
Burcu Zeydan, MDPrincipal InvestigatorMayo Clinic
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I haven't taken any steroids in the last 2 weeks.I do not have any inflammatory brain or spinal cord diseases.I am able to understand and sign a consent form.I can't stay still lying down for 20 minutes.
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Research Study Groups:
This trial has the following groups:- Group 1: Healthy Control Group
- Group 2: Multiple Sclerosis Group
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are researchers recruiting participants for this clinical trial currently?
"According to clinicaltrials.gov, this particular medical exploration is no longer recruiting patients, having been initially posted on May 1st 2023 and last updated March 28th of the same year. Although potential participants for this trial are exhausted, there are 386 other trials actively searching for volunteers at present."
Answered by AI
Does the FDA recognize Healthy Control Group as an approved entity?
"Our in-house research team graded the safety of Healthy Control Group with a 2, as this is merely a Phase 2 trial which does not feature efficacy data but has evidence to suggest that it can be safely administered."
Answered by AI
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