200 Participants Needed

Imaging Techniques for Multiple Sclerosis

JK
Overseen ByJune Kendall-Thomas
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This purpose of this study is research the usefulness of MRI with PET/CT imaging for measuring brain inflammation and its relation to Multiple Sclerosis (MS).

Who Is on the Research Team?

BZ

Burcu Zeydan, MD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for individuals with Multiple Sclerosis (MS) who are already part of certain MS studies or clinics, and healthy controls without inflammatory brain diseases. Participants must be able to lie still for imaging procedures and give consent. Pregnant or breastfeeding women, recent steroid users, and those with MRI safety risks like pacemakers can't join.

Inclusion Criteria

I do not have any inflammatory brain or spinal cord diseases.
Meet the requirements for one of the case or control groups
MS patients undergoing neurologic evaluation procedures as part of Understanding Sex Differences in Multiple Sclerosis Spectrum of Demyelinating Disorders (IRB# 19-002807) Study or the Mayo Clinic Neurology Multiple Sclerosis Clinic
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Exclusion Criteria

Women who are pregnant or cannot stop breastfeeding for 24 hours
I haven't taken any steroids in the last 2 weeks.
Standard safety exclusionary criteria for MRI such as metallic foreign bodies, pacemaker, etc.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo MRI with PET/CT imaging to measure brain inflammation

Baseline
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging

2 days

What Are the Treatments Tested in This Trial?

Interventions

  • C-11 ER176 Radiotracer
  • C11 Pittsburgh Compound B
  • MRI
  • PET/CT scan
Trial Overview The study is testing the effectiveness of combining MRI scans with PET/CT imaging using C-11 ER176 Radiotracer and C11 Pittsburgh Compound B to measure brain inflammation in people with MS.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Multiple Sclerosis GroupExperimental Treatment4 Interventions
Group II: Healthy Control GroupExperimental Treatment4 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+
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