Hyperpolarized Xenon-129 MRI for Idiopathic Pulmonary Fibrosis
(XeMRIIPF Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Idiopathic pulmonary fibrosis has a poor prognosis with limited treatment options. The Investigator hypothesize hyperpolarized Xe129-MRI can be performed in patients with IPF and repeated over time which will detect deficiencies related to perfusion in the lung.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is Hyperpolarized Xenon-129 MRI safe for humans?
How is the treatment Hyperpolarized Xenon-129 MRI unique for idiopathic pulmonary fibrosis?
Hyperpolarized Xenon-129 MRI is unique because it uses inhaled xenon gas to create detailed images of lung function, allowing doctors to see how well gas is transferred from the airspaces to the blood. This provides a new way to assess lung health in idiopathic pulmonary fibrosis, which is different from traditional methods that don't offer such detailed regional information.23678
What data supports the effectiveness of the treatment Hyperpolarized Xenon-129 MRI for Idiopathic Pulmonary Fibrosis?
The research suggests that Hyperpolarized Xenon-129 MRI is promising for monitoring idiopathic pulmonary fibrosis because it can image how gas moves in the lungs without using harmful radiation. This method can help detect lung function issues and track disease progression, potentially improving diagnosis and treatment response assessment.235910
Who Is on the Research Team?
John Kim, MD
Principal Investigator
University of Virginia
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with Idiopathic Pulmonary Fibrosis who can consent to the study. It's not suitable for those with claustrophobia, metal implants, severe heart conditions, chronic kidney failure, cirrhosis, or those needing continuous oxygen. Pregnant or lactating individuals and those with recent respiratory infections are also excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo hyperpolarized Xe-129 MRI to assess pulmonary ventilation and perfusion
Follow-up
Participants are monitored for changes in MRI indices over time
What Are the Treatments Tested in This Trial?
Interventions
- Hyperpolarized Xenon-129
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Virginia
Lead Sponsor