Clonidine Pill for Obesity

Phase-Based Progress Estimates
Obesity+5 MoreClonidine Pill - Drug
18 - 79
All Sexes
What conditions do you have?

Study Summary

This trial will test if 4 weeks of sympathetic nerve activity inhibition can reduce circulating blood concentrations and expression of inflammatory markers.

Eligible Conditions
  • Obesity
  • Insulin Resistance
  • Diabetes
  • High Blood Pressure
  • Sympathetic Nerve Activity
  • Diuretic Drug Reactions

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 0 Secondary · Reporting Duration: 4 Week

4 Week
Adipose Tissue Sample: Efficacy of 4-week supply of Clonidine Compared VS 4-week supply of control condition using hydrochlorothiazide (HCTZ) and a separate placebo treatment

Trial Safety

Safety Progress

1 of 3

Trial Design

3 Treatment Groups

1 of 3
Hydrochlorothiazide (HCTZ)
1 of 3
1 of 3

Experimental Treatment

Non-Treatment Group

60 Total Participants · 3 Treatment Groups

Primary Treatment: Clonidine Pill · Has Placebo Group · Phase 1

Experimental Group · 1 Intervention: Clonidine Pill · Intervention Types: Drug
Hydrochlorothiazide (HCTZ)
Experimental Group · 1 Intervention: Hydrochlorothiazide 12.5Mg Tab · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 4 week

Who is running the clinical trial?

University of Kansas Medical CenterLead Sponsor
403 Previous Clinical Trials
158,843 Total Patients Enrolled
16 Trials studying Obesity
102,885 Patients Enrolled for Obesity
Seth W. W Holwerda, PhDPrincipal InvestigatorUniversity of Kansas Medical Center
1 Previous Clinical Trials
46 Total Patients Enrolled

Eligibility Criteria

Age 18 - 79 · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
on two occasions A person has diabetes if their fasting glucose level is 126 mg/dL or more on two occasions.
You are a male or female, 18-79 years old.
A person who has high blood pressure is called hypertensive
You have insulin resistance.\n
If your waist circ is more than 102 cm (men) or 88 cm (women), you are at a higher risk for developing heart disease and other health problems.

Who else is applying?

What state do they live in?
How old are they?
18 - 6566.7%
What site did they apply to?
University of Kansas Medical Center100.0%
What portion of applicants met pre-screening criteria?
Met criteria66.7%
Did not meet criteria33.3%