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Loop Diuretic

Furosemide for High Blood Pressure

Phase 1 & 2

Recruiting

Led By Annet Kirabo

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

New or pre-existing diagnosis of essential hypertension defined as systolic blood pressure >140 mmHg or >90 mmHg diastolic or taking antihypertensive medications regardless of current blood pressure

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up over 3 days

Awards & highlights

Study Summary

This trial will test whether or not salt-sensitive hypertension can be diagnosed by monocyte salt-sensitivity.

Who is the study for?

This trial is for adults aged 18-60 with a healthy BMI (18.5-24.9) who have high blood pressure, either newly diagnosed or existing, and are currently on medication or have blood pressure above certain levels. It's not open to those with diabetes, recent vaccinations, pregnancy, substance abuse issues, metal implants, autoimmune diseases, claustrophobia that prevents MRI scans or those who've had a recent heart event.Check my eligibility

What is being tested?

The study tests if the drug Furosemide at 40 mg can be used as an indicator of salt-sensitivity in people with high blood pressure by observing immune cell activation. The goal is to see if this response correlates with hypertension due to salt intake.See study design

What are the potential side effects?

Furosemide may cause dehydration and electrolyte imbalances leading to symptoms like dry mouth/thirsty feeling, confusion or weakness; it might also lead to increased urination.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have high blood pressure or am on medication for it.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ over 3 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~over 3 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and over 3 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

The percent of participants with salt sensitive blood pressure

Secondary outcome measures

Percent of participants with immune cell activation

Trial Design

1Treatment groups

Experimental Treatment

Group I: Weinberger protocolExperimental Treatment1 Intervention

During the Weinberger protocol, salt loading will be achieved by the combination of a high-salt diet (isocaloric, 160 mEq Na and 70 mEq K), and an infusion of 2L of saline (300 mEq Na+). Patients will have free access to water but their food will be limited to that provided by the protocol. Salt depletion will be accomplished by administering an isocaloric diet containing 10 mEq Na and 70 mEq K and continued unlimited water intake. At 8 am, 12 noon and 4 pm, subjects will be given 40 mg of furosemide or lasix orally.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Furosemide

FDA approved

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor

861 Previous Clinical Trials

673,163 Total Patients Enrolled

Annet KiraboPrincipal Investigator - Vanderbilt University Medical Center

Vanderbilt University Medical Center

Media Library

Furosemide 40 mg (Loop Diuretic) Clinical Trial Eligibility Overview. Trial Name: NCT03753204 — Phase 1 & 2

High Blood Pressure Research Study Groups: Weinberger protocol

High Blood Pressure Clinical Trial 2023: Furosemide 40 mg Highlights & Side Effects. Trial Name: NCT03753204 — Phase 1 & 2

Furosemide 40 mg (Loop Diuretic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03753204 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment have an age limit?

"The specific age requirements to enroll in this particular trial are between 18 and 60 years old. However, there are 84 other studies for patients that fall outside of this range (under 18 or over 65)."

Answered by AI

How many people have signed up to take part in this research project?

"Yes, the trial is currently recruiting patients. According to information on clinicaltrials.gov, the study was posted on September 1st 2021 and last updated on October 27th 2021. The research needs 20 participants at a single site."

Answered by AI

Are there other scientific papers that mention the use of Furosemide 40 mg?

"There are currently 16 active clinical trials studying the effects of Furosemide 40 mg. Out of these, 6 are in Phase 3. Most notably, 44 different locations across America are running these trials."

Answered by AI

What are some conditions that Furosemide 40 mg is known to ameliorate?

"Furosemide 40 mg is an effective diuretic for treating heart failure, edema, and acute pulmonary edema."

Answered by AI

Are people still able to sign up for this clinical trial?

"The research team is currently looking for participants, as indicated by the clinicaltrials.gov website. This particular trial was originally posted on September 1st, 2021 and has since been updated on October 27th, 2021."

Answered by AI

Who is eligible to participate in this research?

"20 patients, who must be within the age bracket of 18 and 60 and currently have inflammation, will be enrolled in this study. In addition, the following criteria must be met: We will perform a pilot analysis in 20 hypertensive subjects controlled for gender (50% men, 50% women), age (18-60 years), New or pre-existing diagnosis of essential hypertension defined as systolic blood pressure >140 mmHg or >90 mmHg diastolic or taking antihypertensive medications regardless of current blood pressure., BMI (18.5-24.9). Only subjects who give informed consent will be studied"

Answered by AI

Recent research and studies

HypertensionJournal

Definitions and Characteristics of Sodium Sensitivity and Blood Pressure Resistance.

Weinberger, M H, J Z Miller, F C Luft, C E Grim, and N S Fineberg. 1986. “Definitions and Characteristics of Sodium Sensitivity and Blood Pressure Resistance.”. Hypertension. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/01.hyp.8.6_pt_2.ii127.

HypertensionJournal

Sodium and Volume Sensitivity of Blood Pressure. Age and Pressure Change over Time.

Weinberger, M H, and N S Fineberg. 1991. “Sodium and Volume Sensitivity of Blood Pressure. Age and Pressure Change over Time.”. Hypertension. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/01.hyp.18.1.67.

clinicaltrials.govStudy

Salt-Sensitivity and Immunity Cell Activation

Annet Kirabo 2021. "Salt-Sensitivity and Immunity Cell Activation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03753204.

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