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Avocado for Type 2 Diabetes (AVOCADO-T2D Trial)

N/A
Recruiting
Led By John W Apolzan, PhD
Research Sponsored by Pennington Biomedical Research Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participant reported diagnosis of Type 2 diabetes
Age range - 18 - 65 years (inclusive)
Must not have
History of a surgical procedure for weight loss in last 5 years (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve)
Renal insufficiency consisting of potassium over 5.5 (mmol/L) on a non-hemolyzed specimen, or a creatinine over 2.5 mg/dL
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 5 - week 0
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if eating Hass Avocados can help lower blood sugar levels. The study focuses on people who need to manage their blood sugar. Researchers think that Hass Avocados might be better at reducing blood sugar than other fruits with the same number of calories. Avocado oil has been shown to improve glucose tolerance and reduce insulin resistance in animal studies.

Who is the study for?
This trial is for adults aged 18-65 with Type 2 diabetes, a BMI of 27-50, and stable blood sugar control medication. Participants must not be pregnant or trying to conceive, have recent major surgery, unstable heart disease, severe kidney issues, or be on weight loss drugs. They should agree to consume avocados and follow the study protocol.
What is being tested?
The study aims to see if eating Hass Avocados can improve blood sugar levels in people with Type 2 diabetes compared to consuming an equal calorie amount of other fruits during controlled feeding conditions.
What are the potential side effects?
While avocados are generally safe and nutritious, some individuals might experience mild digestive discomfort or allergic reactions when consuming them as part of their diet.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with Type 2 diabetes.
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I am between 18 and 65 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I had weight loss surgery in the last 5 years.
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My kidney function is impaired with high potassium or creatinine levels.
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I have not had major surgery in the last three months.
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I am willing and able to eat avocados as required by the study.
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I am not pregnant, breastfeeding, trying to conceive, and I use effective birth control.
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I am taking high doses of water pills (like furosemide 40mg or more).
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My bilirubin is over 3 mg/dL or my albumin is less than 3 g/dL.
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I do not have uncontrolled stomach or bowel disorders.
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I have diabetes and take insulin or specific diabetes medications.
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I do not have ongoing heart problems like unstable angina.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 5 - week 0
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 5 - week 0 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Fasting Blood Glucose
Secondary study objectives
Fasting Insulin
Fructosamine
Glycated Albumin
Other study objectives
Blood Glucose
Glucose
Insulin

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: AvocadoExperimental Treatment1 Intervention
Participants will consume 1 Hass avocado a day.
Group II: Other Fruit(s)Active Control1 Intervention
Participants in the other fruit arm will receive other fruits.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Type 2 Diabetes include medications like metformin, which reduces glucose production in the liver and improves insulin sensitivity, and lifestyle interventions such as diet and exercise. Nutritional components like those found in Hass Avocados—fiber, healthy fats, and low carbohydrate content—play a crucial role in stabilizing blood sugar levels. Fiber slows glucose absorption, healthy fats improve insulin sensitivity, and low carbohydrate content reduces blood sugar spikes. These mechanisms are vital for Type 2 Diabetes patients as they help maintain better glycemic control, reduce the risk of complications, and improve overall metabolic health.
The Effects of Almonds on Gut Microbiota, Glycometabolism, and Inflammatory Markers in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Oligomeric Proanthocyanidin Complex from Avocado Seed as A Promising α-glucosidase Inhibitor: Characteristics and Mechanisms.Comparative Antidiabetic Activity of Aqueous, Ethanol, and Methanol Leaf Extracts of <i>Persea americana</i> and Their Effectiveness in Type 2 Diabetic Rats.

Find a Location

Who is running the clinical trial?

Pennington Biomedical Research CenterLead Sponsor
308 Previous Clinical Trials
179,184 Total Patients Enrolled
Prachi SinghUNKNOWN
1 Previous Clinical Trials
25 Total Patients Enrolled
Frank L. GreenwayUNKNOWN
3 Previous Clinical Trials
67 Total Patients Enrolled
~19 spots leftby Jun 2025