Lorazepam for Pain During IUD Insertion
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether lorazepam, a medication often used to ease anxiety, can reduce anxiety and pain during the insertion of an Intrauterine Device (IUD). The researchers aim to determine if lorazepam is helpful and practical for individuals receiving an IUD. Suitable participants are those planning to get an IUD at a specific clinic and who can arrange for transportation to and from the appointment. As a Phase 2 trial, the research measures the treatment's effectiveness in an initial, smaller group of people.
Do I have to stop taking my current medications for the trial?
The trial requires that you do not take medications with a central nervous system depressant effect, like opioids or benzodiazepines, to participate.
Is there any evidence suggesting that lorazepam is likely to be safe for humans?
Research has shown that lorazepam is generally safe for people. Studies indicate it causes minimal vein irritation and patients usually tolerate it well. The FDA has already approved lorazepam for other uses, supporting its safety profile.
Although specific data on side effects during IUD insertion is lacking, lorazepam is known for its calming effects, which may help reduce anxiety and pain during the procedure. As this is a Phase 2 trial, safety remains under close observation, but past use of lorazepam suggests it is well-tolerated.12345Why do researchers think this study treatment might be promising?
Lorazepam is unique because it offers a novel approach to managing pain during IUD insertion by targeting anxiety and muscle tension, which can exacerbate discomfort. Unlike the standard of care, which often relies on local anesthetics or nonsteroidal anti-inflammatory drugs, lorazepam is a benzodiazepine that helps calm the nervous system, potentially making the procedure more tolerable. Researchers are excited about this treatment because it could improve the overall experience for patients, offering a more comprehensive pain management option that addresses both physical and psychological aspects of discomfort.
What evidence suggests that lorazepam might be an effective treatment for pain during IUD insertion?
Research has shown that lorazepam might help with anxiety and pain during IUD insertion. Although few studies focus specifically on lorazepam for this use, its calming effects can reduce anxiety. Lowering anxiety might also lessen the perception of pain. Many healthcare providers use medications to manage pain during IUD procedures, often achieving good results. In this trial, participants will receive lorazepam before the IUD insertion to evaluate its effectiveness. Given its known benefits in reducing anxiety and its common use in similar situations, lorazepam could prove effective.13467
Who Is on the Research Team?
Jensena Carlson, MD
Principal Investigator
UW School of Medicine and Public Health
Are You a Good Fit for This Trial?
This trial is for adults who are scheduled to have an IUD inserted at a UW Family Medicine residency clinic. They must be able to rate their anxiety and pain, agree to have a driver for clinic visits, and consent to email communication.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive lorazepam and ibuprofen prior to IUD insertion to measure effects on anxiety and pain
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Lorazepam
Lorazepam is already approved in United States, European Union, Canada for the following indications:
- Anxiety disorders
- Short-term relief of anxiety symptoms
- Preoperative sedation
- Anxiety disorders
- Insomnia
- Preoperative sedation
- Anxiety disorders
- Short-term relief of anxiety symptoms
- Preoperative sedation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Wisconsin, Madison
Lead Sponsor