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Temporo-masseteric Nerve Block for Acute Pain

Phase 2

Recruiting

Led By Gayathri D Subramanian, PhD, DMD

Research Sponsored by Rutgers, The State University of New Jersey

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, post-procedure (day 1) and at post-operative visit (day 8)

Awards & highlights

Study Summary

This trial is testing whether a nerve block can reduce pain for people getting their lower wisdom teeth removed while sedated. People will be asked about their pain and pain meds use for a week after the procedure, and then checked in on 8 days later.

Who is the study for?

This trial is for adults aged 18-64 who need their lower wisdom teeth removed and can consent to the study. They must be healthy enough for sedation, not pregnant, have internet access with a smartphone, and able to take common pain meds like Tylenol or Advil.Check my eligibility

What is being tested?

The study tests if a local anesthetic injection called Temporo-masseteric Nerve Block reduces pain after wisdom tooth removal under sedation. Participants will report their pain levels and medication use over the first week post-surgery.See study design

What are the potential side effects?

Potential side effects may include discomfort at the injection site, possible allergic reactions to the anesthetic used in the nerve block, and typical risks associated with dental procedures such as swelling or infection.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, post-procedure (day 1) and at post-operative visit (day 8)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, post-procedure (day 1) and at post-operative visit (day 8)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, post-procedure (day 1) and at post-operative visit (day 8) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adverse effects

Masticatory muscle pain to palpation- Temporalis and Masseter

Mean Numerical Pain Rating Scale pain score

+3 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Temporo-masseteric Nerve Block (TMNB) Injection with Local AnestheticExperimental Treatment1 Intervention

Following lower third molar extraction under intravenous sedation, the patient will receive the TMNB local anesthetic nerve block using the standard dental local anesthetic, i.e,. 2% lidocaine with 1:100,000 epinephrine, on the side/s of lower wisdom molar extraction/s

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor

429 Previous Clinical Trials

64,212 Total Patients Enrolled

2 Trials studying Acute Pain

144 Patients Enrolled for Acute Pain

Gayathri D Subramanian, PhD, DMDPrincipal InvestigatorRutgers School of Dental Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential hazards should patients be aware of prior to receiving a Temporo-masseteric Nerve Block?

"Our team at Power has assessed the safety of Temporo-masseteric Nerve Block to be a 2, meaning there is some existing evidence that supports its safety but not efficacy."

Answered by AI

Could I fulfill the criteria to participate in this experiment?

"To qualify for this clinical trial, individuals between 18 and 64 years of age with acute pain will be accepted. The study requires 20 participants in total."

Answered by AI

Does this research encompass seniors as study participants?

"Eligible enrollees must be 18 years of age or older and not yet 65."

Answered by AI

Are there still slots available to join this clinical experiment?

"Clinicaltrials.gov states that this investigation is seeking out qualified participants, with the initial posting taking place on September 13th 2022 and most recent editing occurring on October 24th 2022."

Answered by AI

How many individuals have been recruited to partake in this research endeavor?

"Affirmative. According to the clinicaltrials.gov directory, this trial is actively recruiting; it was initially posted on September 13th of 2022 and updated most recently on October 24th of the same year. The research intends to enrol 20 individuals from one location."

Answered by AI

Recent research and studies

Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyJournal

The Twin Block: A Simple Technique to Block Both the Masseteric and the Anterior Deep Temporal Nerves with One Anesthetic Injection

Quek, Samuel, Andrew Young, and Gayathri Subramanian. 2014. “The Twin Block: A Simple Technique to Block Both the Masseteric and the Anterior Deep Temporal Nerves with One Anesthetic Injection”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Elsevier BV. doi:10.1016/j.oooo.2014.01.227.

Anesthesia ProgressJournal

Twin Block in Myogenous Orofacial Pain: Applied Anatomy, Technique Update, and Safety

Quek, Samuel Y. P., Julyana Gomes-Zagury, and Gayathri Subramanian. 2020. “Twin Block in Myogenous Orofacial Pain: Applied Anatomy, Technique Update, and Safety”. Anesthesia Progress. American Dental Society of Anesthesiology (ADSA). doi:10.2344/anpr-67-01-03.

Quintessence InternationalJournal

Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series

“Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. 2017. “Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. JB. Quintessence International 48 (10). DE: Quintessenz Verlags-GmbH: 829–33. doi:10.3290/j.qi.a39094.

clinicaltrials.govStudy