Temporo-masseteric Nerve Block for Acute Pain
Phase-Based Progress Estimates
Effectiveness
Safety
The University Hospital- Dental Clinic, Newark, NJ
Acute Pain
Temporo-masseteric Nerve Block - DrugEligibility
18 - 65
All Sexes
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Eligibility
18 - 65
All Sexes
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Study Summary
This is a pilot study evaluating the ability of the Temporo-masseteric Nerve Block local anesthetic injection (this was called the Twin Block earlier) to reduce pain experienced by individuals undergoing removal of lower third molar(s) under intravenous sedation. Study participants will be queried for pain experience and pain medications taken during the first post-operative week and will present for a follow-up visit on Day 8.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
6 Primary · 0 Secondary · Reporting Duration: Baseline, post-procedure (Day 1) and at post-operative visit (Day 8)
8 Days
Total dose of pain medication- acetaminophen, ibuprofen and hydrocodone
8 days
Adverse effects
Day 8
Masticatory muscle pain to palpation- Temporalis and Masseter
Passive Mouth opening
One week
Mean Numerical Pain Rating Scale pain score
Hour 4
Peak post-operative Pain Score
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Trial Design
1 Treatment Group
Temporo-masseteric Nerve Block (TMNB) Injection with Local Anesthetic
1 of 1
Experimental Treatment
20 Total Participants · 1 Treatment Group
Primary Treatment: Temporo-masseteric Nerve Block · No Placebo Group · Phase 2
Temporo-masseteric Nerve Block (TMNB) Injection with Local Anesthetic
Drug
Experimental Group · 1 Intervention: Temporo-masseteric Nerve Block · Intervention Types: DrugTrial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, post-procedure (day 1) and at post-operative visit (day 8)
Closest Location: The University Hospital- Dental Clinic · Newark, NJ
N/AFirst Recorded Clinical Trial
1 TrialsResearching Acute Pain
0 CompletedClinical Trials
Who is running the clinical trial?
Rutgers, The State University of New JerseyLead Sponsor
361 Previous Clinical Trials
60,167 Total Patients Enrolled
2 Trials studying Acute Pain
144 Patients Enrolled for Acute Pain
Gayathri D Subramanian, PhD, DMDPrincipal InvestigatorRutgers School of Dental Medicine
Eligibility Criteria
Age 18 - 65 · All Participants · 6 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You have a smart phone and internet connection.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
References
- Quek, Samuel, Andrew Young, and Gayathri Subramanian. 2014. “The Twin Block: A Simple Technique to Block Both the Masseteric and the Anterior Deep Temporal Nerves with One Anesthetic Injection”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Elsevier BV. doi:10.1016/j.oooo.2014.01.227.
- Quek, Samuel Y. P., Julyana Gomes-Zagury, and Gayathri Subramanian. 2020. “Twin Block in Myogenous Orofacial Pain: Applied Anatomy, Technique Update, and Safety”. Anesthesia Progress. American Dental Society of Anesthesiology (ADSA). doi:10.2344/anpr-67-01-03.
- “Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. 2017. “Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. JB. Quintessence International 48 (10). DE: Quintessenz Verlags-GmbH: 829–33. doi:10.3290/j.qi.a39094.
- Gayathri Dental Subramanian 2022. "Reducing Pain From Wisdom Molar Extractions". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05335070.
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