Temporo-masseteric Nerve Block for Acute Pain

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
The University Hospital- Dental Clinic, Newark, NJ
Acute Pain
Temporo-masseteric Nerve Block - Drug
Eligibility
18 - 65
All Sexes
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Study Summary

This is a pilot study evaluating the ability of the Temporo-masseteric Nerve Block local anesthetic injection (this was called the Twin Block earlier) to reduce pain experienced by individuals undergoing removal of lower third molar(s) under intravenous sedation. Study participants will be queried for pain experience and pain medications taken during the first post-operative week and will present for a follow-up visit on Day 8.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

6 Primary · 0 Secondary · Reporting Duration: Baseline, post-procedure (Day 1) and at post-operative visit (Day 8)

8 Days
Total dose of pain medication- acetaminophen, ibuprofen and hydrocodone
8 days
Adverse effects
Day 8
Masticatory muscle pain to palpation- Temporalis and Masseter
Passive Mouth opening
One week
Mean Numerical Pain Rating Scale pain score
Hour 4
Peak post-operative Pain Score

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Temporo-masseteric Nerve Block (TMNB) Injection with Local Anesthetic
1 of 1
Experimental Treatment

20 Total Participants · 1 Treatment Group

Primary Treatment: Temporo-masseteric Nerve Block · No Placebo Group · Phase 2

Temporo-masseteric Nerve Block (TMNB) Injection with Local Anesthetic
Drug
Experimental Group · 1 Intervention: Temporo-masseteric Nerve Block · Intervention Types: Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, post-procedure (day 1) and at post-operative visit (day 8)
Closest Location: The University Hospital- Dental Clinic · Newark, NJ
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N/AFirst Recorded Clinical Trial
1 TrialsResearching Acute Pain
0 CompletedClinical Trials

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor
361 Previous Clinical Trials
60,167 Total Patients Enrolled
2 Trials studying Acute Pain
144 Patients Enrolled for Acute Pain
Gayathri D Subramanian, PhD, DMDPrincipal InvestigatorRutgers School of Dental Medicine

Eligibility Criteria

Age 18 - 65 · All Participants · 6 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.