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Pre-Transplant Clofarabine + Melphalan for Myelodysplastic Syndrome and Leukemia
Study Summary
This trial is testing how well clofarabine and melphalan work before a stem cell transplant for patients with myelodysplasia or acute leukemia in remission, or chronic myelomonocytic leukemia.
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Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- The stem cells used for donation can come from either the blood or the bone marrow.You rely on regular blood transfusions to maintain your health.You have a type of blood disorder called therapy-related MDS or MDS that developed from another blood disorder, except for myelofibrosis.If you have a type of blood disorder called MDS that has turned into AML, you must be in a period where the disease is not active or getting worse.You are allergic to clofarabine, melphalan, sirolimus, or tacrolimus.Using cord blood as a source of donor cells is not allowed.You cannot have other types of cancer that need treatment or might get worse during the study. However, if you had skin cancer, early stage cervical cancer, or early stage prostate cancer before and it's been treated with no signs of the disease left, you may still be able to participate.
- Group 1: Treatment (clofarabine, melphalan, transplant)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has clofarabine been confirmed to meet the standards of regulatory clearance?
"The safety of clofarabine has been evaluated to be a 2, as this clinical trial is in its second phase. Although there is some evidence for the drug's security, no data exists at the moment that fully supports efficacy."
How is clofarabine typically employed in treatment?
"Clofarabine is typically utilized to treat organ transplantation, as well as dermatitis, atopic rejection, kidney transplants and psoriasis."
What is the uppermost cap on participants in this experiment?
"This clinical trial is not accepting applicants at the present time. It was initially posted on February 10th 2014 and last updated nearly 8 years later, on February 17th 2022. If you are looking to participate in another medical study, there are 2810 trials with open recruitment for patients suffering from acute myeloid leukemia and 363 studies utilizing clofarabine presently recruiting individuals."
Are seniors of a certain age qualified to participate in this research study?
"To be included in this medical trial, those enrolling must between 18 and 75 years old. For younger or older patients respectively, there are 950 studies and 2391 studies available."
What are the eligibility criteria for enrolling in this research trial?
"This clinical trial is accepting participants aged between 18 and 75 with acute myeloid leukemia. Approximately 77 patients are being sought for this medical investigation."
Is it currently feasible to enlist for this investigation?
"As per clinicaltrials.gov, this specific medical experiment is no longer recruiting participants as it was last updated on February 17th 2022. Despite that fact, there are many other trials actively searching for test subjects right now - 3173 to be exact!"
Have any other scientific experiments utilized clofarabine?
"At present, there are 363 active clinical trials for clofarabine with 49 in Phase 3. Numerous sites from San Antonio, Texas to the far reaches of America are hosting studies on this drug, amounting to 3885 locations participating overall."
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