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Neurostimulation Device

Spinal Cord Stimulation for Stroke Recovery

N/A
Waitlist Available
Led By Marco Capogrosso, PhD
Research Sponsored by Lee Fisher, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must be between the ages of 21 and 70 years old.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7, 15, 21, 29 days
Awards & highlights

Study Summary

This trial is testing whether electrical stimulation of the spinal cord can help people with paralysis in one arm recover movement. A device is implanted to deliver the stimulation, and then removed after a month.

Who is the study for?
This trial is for adults aged 21-70 who've had a stroke at least 6 months ago, resulting in arm weakness but not complete paralysis. They should be able to participate actively and not have severe diseases, cognitive issues, or be pregnant. They can't take certain medications or have implants that could interfere with the study.Check my eligibility
What is being tested?
Researchers are testing if electrical stimulation of the spinal cord can help activate arm and hand muscles in stroke survivors with hemiplegia. Participants will get a temporary implant to deliver this stimulation and see if it improves their ability to move their limbs.See study design
What are the potential side effects?
Potential side effects may include discomfort from the surgical procedure for implant placement and removal, possible skin irritation from the device, muscle pain due to electrical stimulation, and risks associated with any surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 21 and 70 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7, 15, 21, 29 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7, 15, 21, 29 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adverse Events
Discomfort and Pain
Secondary outcome measures
Cortico-spinal Tract Integrity
Dexterity / Function: Action Research Arm Test
Joint Velocity
+11 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Epidural electrical stimulation of the cervical spinal cordExperimental Treatment1 Intervention
Individuals with prior subcortical stroke and hemiparesis of the upper extremity.

Find a Location

Who is running the clinical trial?

Lee Fisher, PhDLead Sponsor
3 Previous Clinical Trials
50 Total Patients Enrolled
Marco CapogrossoLead Sponsor
2 Previous Clinical Trials
30 Total Patients Enrolled
Marco Capogrosso, PhDPrincipal Investigator - University of Pittsburgh
University of Pittsburgh

Media Library

Epidural electrical stimulation (EES) of the cervical spinal cord (Neurostimulation Device) Clinical Trial Eligibility Overview. Trial Name: NCT04512690 — N/A
Stroke Research Study Groups: Epidural electrical stimulation of the cervical spinal cord
Stroke Clinical Trial 2023: Epidural electrical stimulation (EES) of the cervical spinal cord Highlights & Side Effects. Trial Name: NCT04512690 — N/A
Epidural electrical stimulation (EES) of the cervical spinal cord (Neurostimulation Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04512690 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available for participants in this trial?

"Affirmative. According to clinicaltrials.gov, this research effort is actively recruiting participants with its first posting on March 24th 2021 and most recent update on August 11th 2022. The trial requires 15 patients from one site."

Answered by AI

How many individuals are currently taking part in the experiment?

"Affirmative. According to the research posted on clinicaltrials.gov, this medical investigation is still seeking volunteers and began recruiting on March 24th 2021. The most recent update was issued August 11th 2022 and 15 participants are needed at a single location."

Answered by AI

What aspirational objectives has this research endeavor set out to accomplish?

"As the primary outcome, this medical trial will assess evoked motor responses in arm muscles through surface electromyography (EMG) over a 4-week period. As secondary outcomes, examiners will look into sensory motor integration using the KINARM robot; evaluate impairment levels with Fugl-Meyer Assessment scores; and measure spinal circuit excitability via H-reflexes of arm muscles pre and post implantation. Ultimately, it is anticipated that these measures can demonstrate how Spinal cord Stimulation affects sensori-to-motoneuron excitability."

Answered by AI

Am I qualified to partake in this research?

"This medical trial seeks 15 volunteers between the ages of 21 and 70 who are afflicted with a central nervous system disorder. Additionally, they must have had either an ischemic or hemorrhagic stroke more than 6 months prior to enrollment which has caused hemiparesis. The Fugl-Meyer scale should also produce scores that range from 7 up to 45 in order for them to be eligible."

Answered by AI

Are participants aged 50 or older being included in this trial?

"Patients aged 21 to 70 are qualified for this investigation. Those younger than 18 and older than 65 can still participate in 145 clinical trials and 1513 studies respectively."

Answered by AI
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~5 spots leftby Sep 2025