Broccoli Sprouts for Ulcerative Colitis
Trial Summary
What is the purpose of this trial?
This trial is testing if eating broccoli sprouts can help patients with mild ulcerative colitis by increasing a compound called sulforaphane in their bodies, which may reduce inflammation. Sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables such as broccoli and brussels sprouts, has a variety of biological functions.
Will I have to stop taking my current medications?
You can continue taking your current medications for ulcerative colitis as long as the doses are stable and meet the study's requirements. However, you cannot take NSAIDs and should not expect any dose changes during the study.
What data supports the effectiveness of the treatment Broccoli Sprouts for Ulcerative Colitis?
Research shows that broccoli sprouts, which are rich in sulforaphane, can reduce inflammation and improve gut health in mice with colitis, a condition similar to ulcerative colitis. This suggests that broccoli sprouts might help manage symptoms of ulcerative colitis by reducing inflammation and supporting a healthy gut microbiome.12345
Is it safe to consume broccoli sprouts or sulforaphane-rich broccoli sprouts?
How does the treatment with broccoli sprouts differ from other treatments for ulcerative colitis?
Broccoli sprouts are unique because they contain high levels of glucoraphanin, which is converted by gut bacteria into sulforaphane, a compound with anti-inflammatory properties. This treatment focuses on restoring gut microbiota balance and reducing inflammation through dietary intervention, offering a natural and potentially more affordable option compared to traditional medications.13458
Research Team
Grace Chen
Principal Investigator
University of Michigan
Eligibility Criteria
This trial is for adults with mild ulcerative colitis, who are on a stable dose of certain medications like Aminosalicylic acids or Imuran. Participants should have a BMI between 18.5-40 and not be consuming more than 5 ½ cups of fruits and vegetables daily. They must understand the study and consent to it.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume broccoli sprouts to assess the impact on sulforaphane levels and inflammatory markers
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Broccoli Sprouts (Cruciferous Vegetables)
Broccoli Sprouts is already approved in Japan for the following indications:
- Ulcerative Colitis
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan
Lead Sponsor
University of Maine
Collaborator