What is Arthrotec
MisoprostolThe Generic name of this drug
Treatment SummaryMisoprostol is a medication used to reduce the risk of ulcers caused by taking certain types of NSAID drugs. It can also be used to manage miscarriages, prevent post-partum bleeding, and terminate early pregnancies. Misoprostol works by stimulating prostaglandin receptors in the stomach and uterus, which reduces gastric acid production, and increases the strength and frequency of uterine contractions. The FDA approved misoprostol in 1988.
Cytotecis the brand name
Arthrotec Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cytotec
Misoprostol
1986
107
Approved as Treatment by the FDA
Misoprostol, also known as Cytotec, is approved by the FDA for 4 uses which include prophylaxis of Gastric ulcer and Gastric Ulcer .prophylaxis of Gastric ulcer
Gastric Ulcer
NSAID use
Medically induced abortion
Used to treat Medically induced abortion in combination with Mifepristone
Effectiveness
How Arthrotec Affects PatientsMisoprostol is a medication that helps protect the stomach from ulcers caused by taking NSAIDs. It can also help manage miscarriages and can be used on its own or with another drug, mifepristone, to terminate a pregnancy in the early stages. Depending on the method of administration, it may take 8-100 minutes to take effect, and its effects last for 2-4 hours.
How Arthrotec works in the bodyMisoprostol is a medication that reduces stomach acid, increases mucus and bicarbonate secretion, and thickens the protective layer of the stomach. It also makes contractions in the uterus stronger and more frequent, while loosening the neck of the uterus.
When to interrupt dosage
The advised measure of Arthrotec is contingent upon the diagnosed ailment, including Incomplete Abortion, prophylaxis of Gastric ulcer and Missed Abortion. The measure of dosage can be found in the table beneath, contingent upon the delivery technique (e.g. Tablet - Oral or Oral).Condition
Dosage
Administration
Incomplete Abortion
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
prophylaxis of Gastric ulcer
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Missed Abortion
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Cervix Uteri
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
NSAID use
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Gastric Ulcer
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Postpartum Haemorrhage (PPH)
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Medically induced abortion
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Postpartum Hemorrhage
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Labour
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Induction of Labour
0.2 mg, , 0.1 mg
Tablet - Oral, Oral, , Tablet, Tablet, film coated, Buccal; Oral, Tablet, delayed release, Tablet, delayed release - Oral, Kit; Tablet, Tablet, film coated - Oral, Kit; Tablet - Buccal; Oral
Warnings
Arthrotec has one contraindication, and it should not be taken when experiencing the conditions listed in the table below.Arthrotec ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Common Arthrotec Drug Interactions
Drug Name
Risk Level
Description
Carbetocin
Major
The risk or severity of adverse effects can be increased when Misoprostol is combined with Carbetocin.
Oxytocin
Major
The risk or severity of adverse effects can be increased when Misoprostol is combined with Oxytocin.
Arthrotec Toxicity & Overdose RiskThe toxic dose of misoprostol in rats is 81mg/kg and 27mg/kg in mice. Overdosing on misoprostol can lead to drowsiness, shaking, seizures, difficulty breathing, stomach pain, diarrhea, fever, heart palpitations, low blood pressure, and slow heartbeat. Dialysis is not likely to help, but activated charcoal taken by mouth may reduce absorption. To treat an overdose, supportive care should be provided which may include removing undissolved tablets, fluids, pain relievers, and other medications depending on the symptoms.
Arthrotec Novel Uses: Which Conditions Have a Clinical Trial Featuring Arthrotec?
3 active trials are currently being conducted to explore the potential of Arthrotec in providing Medically induced abortion, prophylaxis of Gastric ulcer and NSAID use.Condition
Clinical Trials
Trial Phases
Medically induced abortion
0 Actively Recruiting
prophylaxis of Gastric ulcer
0 Actively Recruiting
NSAID use
0 Actively Recruiting
Postpartum Haemorrhage (PPH)
2 Actively Recruiting
Phase 2
Induction of Labour
1 Actively Recruiting
Not Applicable
Incomplete Abortion
0 Actively Recruiting
Postpartum Hemorrhage
0 Actively Recruiting
Gastric Ulcer
1 Actively Recruiting
Not Applicable
Labour
0 Actively Recruiting
Missed Abortion
0 Actively Recruiting
Cervix Uteri
0 Actively Recruiting
Arthrotec Reviews: What are patients saying about Arthrotec?
5Patient Review
12/26/2014 I've been taking this medication for four days now and I'm already seeing a lot of improvement. I used to take ibuprofen for my arthritis pain, but this Arthrotec 50 is much better. I don't have any pain in my hands, back, etc., and I can finally sleep through the night.
5Patient Review
11/9/2013 Arthrotec has given me such relief from my osteoarthritis pain. It's been a lifesaver, working almost immediately to provide pain relief. I highly recommend it to anyone struggling with similar issues.
5Patient Review
1/5/2016 Aethrotec 50 was prescribed to me by my doctor to help with the pain while I waited for hip replacements. It's the only thing that's helped and it's been a miracle. I don't need surgery anymore and I can live again thanks to this medication. The downside is that it's hard on my stomach and bowels, but it's worth it!
5Patient Review
9/16/2013 I was struggling with knee pain for over a year and wasn't getting any relief from other methods. This treatment has been really effective in managing my pain, to the point where I can now skip a day without having too much discomfort.
5Patient Review
3/4/2014 I would not recommend this to people who are struggling with swelling, as it only made my own edema worse.
5Patient Review
1/12/2016 I've been on this drug for nearly two decades and it's changed my life. The pain I was in before starting this treatment was so bad that I couldn't walk most days. But since taking it, I haven't had any negative side effects.
5Patient Review
2/26/2022 I was in a lot of pain before starting this treatment, and I'm amazed at how quickly it's helped.
5Patient Review
7/4/20134.7Patient Review
3/30/2014 This treatment has allowed me to do things I really enjoy again, like going out to eat or see a movie. Before, even just walking around my own house was agonizing due to the swelling and pain in my knee.
4.7Patient Review
3/29/2015 This drug has been really effective for me and it's allowed me to do things that I haven't been able to do in years, like walk long distances. I don't have any side effects from it which is great. I've been using it for 6-8 months now and hopefully it will continue to be effective.
4.7Patient Review
1/25/2022 I had to stop taking opioids because my GP wasn't willing to prescribe them. I've got general osteoarthritis and this treatment (Arthrotec 50mg) has worked great for me with few side effects. I only take it 5x per week because I don't want to constantly monitor my blood levels. Highly recommended!
4Patient Review
6/22/2014 After months of severe pain, I took Arthrotec for 3-4 days and it worked very well. I stopped taking it after that and it also worked well on a toothache.
3.7Patient Review
2/8/2014 I take this medication for migraines and it has been really effective. I still get the aura but no pain after.
Patient Q&A Section about arthrotec
Can Arthrotec be used for body pain?
"Arthrotec contains diclofenac, a nonsteroidal anti-inflammatory drug, and misoprostol. The diclofenac in Arthrotec works by reducing substances in the body that cause pain and inflammation. Arthrotec is taken once or twice daily." - Anonymous Online Contributor
Unverified Answer
Is Arthrotec the same as diclofenac?
"It helps to protect the stomach lining from the effects of diclofenac.
Arthrotec is a combination of diclofenac and misoprostol. Diclofenac is an NSAID, which blocks the production of chemicals that cause pain and inflammation. Misoprostol is a prostaglandin E1 analog, which helps protect the stomach lining from the effects of diclofenac." - Anonymous Online Contributor
Unverified Answer
Is Arthrotec the same as ibuprofen?
"The drugs Arthrotec and ibuprofen both contain a nonsteroidal anti-inflammatory drug (NSAID). Arthrotec also contains a prostaglandin that protects the stomach from the irritating effects of NSAIDs. Ibuprofen is available under brand names such as Advil and Motrin, and also as a generic drug." - Anonymous Online Contributor
Unverified Answer
What is Arthrotec used for?
"Arthrotec 75 is a non-steroidal, anti-inflammatory drug that is effective in treating the signs and symptoms of arthritic conditions. Diclofenac, an active ingredient in Arthrotec 75, is responsible for the drug's anti-inflammatory and analgesic properties." - Anonymous Online Contributor
Unverified Answer