Phenylbutazone

Chronic Pain, Inflammation, arthritic pain + 1 more
Treatment
20 Active Studies for Phenylbutazone

What is Phenylbutazone

PhenylbutazoneThe Generic name of this drug
Treatment SummaryPhenylbutazone is a medication used to reduce inflammation, fever, and pain. It is most commonly used to treat ankylosing spondylitis, rheumatoid arthritis, and Reiter’s syndrome (still being investigated). However, due to potential risks, it is not recommended for treating gouty arthritis.
image of different drug pills on a surface
Phenylbutazone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Phenylbutazone
0

Effectiveness

How Phenylbutazone Affects PatientsPhenylbutazone is a synthetic drug used to treat inflammatory conditions. It works by reducing the production of two types of molecules (prostaglandin H and prostacyclin) that can cause constriction of blood vessels, clotting of blood (platelet aggregation), and pain in the body.
How Phenylbutazone works in the bodyPhenylbutazone works by blocking the production of proteins that cause inflammation. This reduces inflammation in the affected area.

When to interrupt dosage

The proposed measure of Phenylbutazone is contingent upon the ascertained condition, including Inflammation, Osteoarthritis and Chronic Pain. The amount of dosage is contingent upon the technique of delivery (e.g. Oral or Tablet) showcased in the table hereinafter.
Condition
Dosage
Administration
Chronic Pain
, 100.0 mg
Tablet, Tablet - Oral, , Oral
Inflammation
, 100.0 mg
Tablet, Tablet - Oral, , Oral
arthritic pain
, 100.0 mg
Tablet, Tablet - Oral, , Oral
Inflammation
, 100.0 mg
Tablet, Tablet - Oral, , Oral

Warnings

Phenylbutazone Contraindications
Condition
Risk Level
Notes
Dermatitis
Do Not Combine
Varicose Ulcer
Do Not Combine
Risk cutaneous lesions
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phenylbutazone may interact with Pulse Frequency
There are 20 known major drug interactions with Phenylbutazone.
Common Phenylbutazone Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Phenylbutazone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Phenylbutazone.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Phenylbutazone.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Phenylbutazone.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Phenylbutazone.
Phenylbutazone Toxicity & Overdose RiskThe toxic dose of a drug in mice is 238mg/kg, rabbits is 781mg/kg, and rats is 245mg/kg or 375 mg/kg depending on the species.
image of a doctor in a lab doing drug, clinical research

Phenylbutazone Novel Uses: Which Conditions Have a Clinical Trial Featuring Phenylbutazone?

512 ongoing trials are analyzing the potential of Phenylbutazone to reduce Osteoarthritis, Inflammation, and Chronic Pain symptoms.
Condition
Clinical Trials
Trial Phases
Inflammation
59 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
arthritic pain
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Patient Q&A Section about phenylbutazone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is phenylbutazone the same as Bute?

"Phenylbutazone, also known as "bute", is an NSAID that can be used to short-term treat pain and fever in animals."

Answered by AI

What is use of phenylbutazone?

"Phenylbutazone was introduced in the early 1950s to treat arthritis and other inflammatory musculoskeletal disorders in humans, and was soon widely used to treat animals, especially horses, suffering from pain and stiffness."

Answered by AI

What does phenylbutazone do to humans?

"Phenylbutazone can cause blood disorders like aplastic anemia, which causes the bone marrow to stop producing enough red and white blood cells and platelets. People with severe forms of the disease are at risk of life-threatening infections or bleeding."

Answered by AI

Can humans have phenylbutazone?

"Phenylbutazone is a nonsteroidal anti-inflammatory drug that used to be prescribed for the treatment of arthritic conditions, but it is no longer available for use in humans because of its numerous side effects, including aplastic anemia."

Answered by AI

Clinical Trials for Phenylbutazone

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Image of Baylor College of Medicine/Texas Children's Hospital in Austin, United States.

Guided Imagery Therapy for Abdominal Pain

7 - 12
All Sexes
Austin, TX
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application. This intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.
Waitlist Available
Has No Placebo
Baylor College of Medicine/Texas Children's Hospital (+1 Sites)
Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.Go to Trials
Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Image of UConn Health in Farmington, United States.

Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)
Waitlist Available
Has No Placebo
UConn HealthCutter Lindbergh, Ph.D.
Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.Go to Trials
Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.Go to Trials
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