Phenylbutazone

Chronic Pain, Inflammation, arthritic pain + 1 more
Treatment
20 Active Studies for Phenylbutazone

What is Phenylbutazone

PhenylbutazoneThe Generic name of this drug
Treatment SummaryPhenylbutazone is a medication used to reduce inflammation, fever, and pain. It is most commonly used to treat ankylosing spondylitis, rheumatoid arthritis, and Reiter’s syndrome (still being investigated). However, due to potential risks, it is not recommended for treating gouty arthritis.
image of different drug pills on a surface
Phenylbutazone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Phenylbutazone
0

Effectiveness

How Phenylbutazone Affects PatientsPhenylbutazone is a synthetic drug used to treat inflammatory conditions. It works by reducing the production of two types of molecules (prostaglandin H and prostacyclin) that can cause constriction of blood vessels, clotting of blood (platelet aggregation), and pain in the body.
How Phenylbutazone works in the bodyPhenylbutazone works by blocking the production of proteins that cause inflammation. This reduces inflammation in the affected area.

When to interrupt dosage

The proposed measure of Phenylbutazone is contingent upon the ascertained condition, including Inflammation, Osteoarthritis and Chronic Pain. The amount of dosage is contingent upon the technique of delivery (e.g. Oral or Tablet) showcased in the table hereinafter.
Condition
Dosage
Administration
Chronic Pain
, 100.0 mg
, Oral, Tablet, Tablet - Oral
Inflammation
, 100.0 mg
, Oral, Tablet, Tablet - Oral
arthritic pain
, 100.0 mg
, Oral, Tablet, Tablet - Oral
Inflammation
, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Phenylbutazone Contraindications
Condition
Risk Level
Notes
Dermatitis
Do Not Combine
Varicose Ulcer
Do Not Combine
Risk cutaneous lesions
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Phenylbutazone may interact with Pulse Frequency
There are 20 known major drug interactions with Phenylbutazone.
Common Phenylbutazone Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Phenylbutazone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Phenylbutazone.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Phenylbutazone.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Phenylbutazone.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Phenylbutazone.
Phenylbutazone Toxicity & Overdose RiskThe toxic dose of a drug in mice is 238mg/kg, rabbits is 781mg/kg, and rats is 245mg/kg or 375 mg/kg depending on the species.
image of a doctor in a lab doing drug, clinical research

Phenylbutazone Novel Uses: Which Conditions Have a Clinical Trial Featuring Phenylbutazone?

512 ongoing trials are analyzing the potential of Phenylbutazone to reduce Osteoarthritis, Inflammation, and Chronic Pain symptoms.
Condition
Clinical Trials
Trial Phases
Inflammation
66 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
arthritic pain
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Chronic Pain
144 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1

Patient Q&A Section about phenylbutazone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is phenylbutazone the same as Bute?

"Phenylbutazone, also known as "bute", is an NSAID that can be used to short-term treat pain and fever in animals."

Answered by AI

What is use of phenylbutazone?

"Phenylbutazone was introduced in the early 1950s to treat arthritis and other inflammatory musculoskeletal disorders in humans, and was soon widely used to treat animals, especially horses, suffering from pain and stiffness."

Answered by AI

What does phenylbutazone do to humans?

"Phenylbutazone can cause blood disorders like aplastic anemia, which causes the bone marrow to stop producing enough red and white blood cells and platelets. People with severe forms of the disease are at risk of life-threatening infections or bleeding."

Answered by AI

Can humans have phenylbutazone?

"Phenylbutazone is a nonsteroidal anti-inflammatory drug that used to be prescribed for the treatment of arthritic conditions, but it is no longer available for use in humans because of its numerous side effects, including aplastic anemia."

Answered by AI

Clinical Trials for Phenylbutazone

Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.
Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.
Have you considered Phenylbutazone clinical trials? We made a collection of clinical trials featuring Phenylbutazone, we think they might fit your search criteria.
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