Malathion

Head

Treatment

1 FDA approval

0 Active Studies for Malathion

Treatment for

Head

What is Malathion

MalathionThe Generic name of this drug

Treatment SummaryMalathion is a pesticide used for the treatment of head lice. It works by blocking the signals sent from the nerves to the muscles, resulting in paralysis and death of the lice. Malathion is very effective, but has low toxicity to humans.

Ovideis the brand name

image of different drug pills on a surface

Malathion Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ovide

Malathion

1982

Approved as Treatment by the FDA

Malathion, also called Ovide, is approved by the FDA for 1 uses such as Head .

Head

Effectiveness

How Malathion Affects PatientsMalathion is a type of insecticide used to get rid of mosquitos and other flying bugs. It is also used in pharmaceuticals to eliminate head lice. Malathion works by blocking an enzyme in the body called cholinesterase, which is caused by its active ingredient malaoxon and phosphorus thionate impurities.

How Malathion works in the bodyMalathion is a type of insecticide that stops a neuron from returning to its resting state. It does this by blocking the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This prevents the neuron from being able to relax, leading to muscle spasms and eventually death. Malathion is toxic to aquatic organisms, but has relatively low toxicity for birds and mammals. Its main metabolites are acid derivatives, with a small amount of malaoxon, which is the strongest cholinesterase inhibitor.

When to interrupt dosage

The quantity of Malathion is contingent upon the diagnosed ailment. The dosage also depends on the approach of delivery as noted in the table below.

Condition

Dosage

Administration

Head

5.0 mg/mL, , 0.5 mg/mL

, Topical, Lotion, Lotion - Topical

Warnings

Malathion has one contraindication, so it should not be used when experiencing any of the states listed in the following table.Malathion Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 6 known major drug interactions with Malathion.

Common Malathion Drug Interactions

Drug Name

Risk Level

Description

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Malathion is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Malathion is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Malathion is combined with Ziprasidone.

Fexinidazole

Moderate

The risk or severity of adverse effects can be increased when Malathion is combined with Fexinidazole.

Haloperidol

Moderate

The risk or severity of QTc prolongation can be increased when Malathion is combined with Haloperidol.

Malathion Toxicity & Overdose RiskTaking too much malathion can cause chest tightness, trouble breathing, slow or fast heartbeat, trembling, unsteadiness, blurred vision, and confusion. In more serious cases, a person may experience a coma, seizures, stopped breathing, and paralysis. Malathion can also be irritating to the skin and eyes. The lowest toxic dose of malathion in rats has been found to be greater than 1000 mg/kg when taken orally and greater than 4000 mg/kg when applied to the skin.

image of a doctor in a lab doing drug, clinical research

Malathion Novel Uses: Which Conditions Have a Clinical Trial Featuring Malathion?

Currently, there are zero active studies investigating the potential of Malathion to provide relief for Head-related conditions.

Condition

Clinical Trials

Trial Phases

Head

0 Actively Recruiting