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What is Orudis
KetoprofenThe Generic name of this drug
Treatment SummaryKetoprofen is a pain reliever and fever reducer that belongs to a class of drugs called nonsteroidal anti-inflammatory agents (NSAIAs). It helps reduce inflammation, pain, and fever.
Ketoprofenis the brand name
Orudis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ketoprofen
Ketoprofen
1993
51
Approved as Treatment by the FDA
Ketoprofen, also known as Ketoprofen, is approved by the FDA for 3 uses such as Ankylosing Spondylitis and Post Partum Pain .Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Post Partum Pain
Helps manage Post Partum Pain
Postoperative Pain
Helps manage Postoperative pain
Effectiveness
How Orudis Affects PatientsKetoprofen is a type of medicine (nonsteroidal anti-inflammatory agent) that is used to reduce pain and fever. It works by blocking the production of certain chemicals that are responsible for inflammation, swelling, and pain. It is commonly used to treat rheumatoid arthritis, osteoarthritis, menstrual cramps, and other moderate pain.
How Orudis works in the bodyKetoprofen works by blocking an enzyme called cyclooxygenase-2 (COX-2). This enzyme is involved in producing hormones that cause pain, fever, and inflammation. Blocking the enzyme reduces these hormones, which helps reduce pain and inflammation. It can also help lower fever. It might also prevent the body from making other hormones that can cause upset stomach and ulcers. Ketoprofen also helps stabilize cell walls and reduces the amount of a hormone that causes swelling. This can help reduce fever by increasing blood flow and allowing the body to cool off.
When to interrupt dosage
The measure of Orudis is contingent upon the diagnosed condition, such as Sprains, Ankylosing Spondylitis and Pain. The amount of dosage may differ, in light of the application technique (e.g. Capsule, extended release - Oral or Tablet, delayed release) featured in the table below.Condition
Dosage
Administration
Rheumatoid Arthritis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Sprains
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Post Partum Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Postoperative Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Migraine
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
prophylaxis of migraine headaches
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Osteoarthritis (OA)
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Ankylosing Spondylitis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Primary Dysmenorrhoea
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Mild pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Muscle Strain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Warnings
Orudis has two contraindications and should be avoided when encountering the conditions presented in the following table.Orudis ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Common Orudis Drug Interactions
Drug Name
Risk Level
Description
Allantoin
Major
The risk or severity of adverse effects can be increased when Ketoprofen is combined with Allantoin.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ketoprofen.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Ketoprofen.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ketoprofen.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Ketoprofen.
Orudis Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 62.4mg/kg when taken orally. Symptoms of overdosing may include drowsiness, vomiting, and stomach pain. Common side effects are usually mild and affect the digestive system, such as feeling bloated, nausea, diarrhea, stomach pain, constipation, and gas.
Orudis Novel Uses: Which Conditions Have a Clinical Trial Featuring Orudis?
153 active investigations are currently evaluating the potential of Orudis to alleviate Post Partum Pain, Rheumatoid Arthritis and Ankylosing Spondylitis.Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Mild pain
0 Actively Recruiting
Muscle Strain
1 Actively Recruiting
Not Applicable
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Osteoarthritis (OA)
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Sprains
0 Actively Recruiting
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Pain
0 Actively Recruiting
Postoperative Pain
21 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2
Post Partum Pain
0 Actively Recruiting
Orudis Reviews: What are patients saying about Orudis?
5Patient Review
1/18/2012 I have Rheumatoid Arthritis, and I've been using this treatment for nearly 20 years. It works well for me, better than Viox or Celebrex ever did.
4.7Patient Review
10/23/2008 Orudis is excellent for menstrual cramps. I had results within thirty minutes of taking it and would recommend it to anyone with similar issues. The only downside is that it made me feel very sleepy.
4.3Patient Review
6/23/2008 I was prescribed this for my TMJ, but I've found it works better on arthritis than any other NSAID. It's easy to use; however, the directions are to take 6 pills three times a day, so it can be hard to keep track of how many you've taken.
2Patient Review
6/3/2008 I was prescribed this for a wrist sprain, but it only made the problem worse. I saw no relief after three days of treatment.
Patient Q&A Section about orudis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is orudis used for?
"This medication is an NSAID that works by blocking the production of natural substances that cause inflammation, helping to decrease swelling, pain, or fever."
Answered by AI
Is orudis still available?
"On August 24th, 2005, Wyeth sent a letter to the FDA informing them of the company's decision to stop manufacturing ORUDIS KT (ketoprofen) tablets. These were 12.5 mg tablets, and they were moved to the "Discontinued Drug Product List" section of the Orange Book."
Answered by AI
Why was orudis discontinued?
"Orudis KT is not available anymore because some studies found that it could possibly lead to a heart attack, stroke, irritation or bleeding in the stomach and intestines."
Answered by AI
What is the drug ketoprofen used for?
"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can be used to relieve pain, inflammation, swelling, stiffness, and joint pain. This medicine requires a prescription from a doctor."
Answered by AI