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Procedure

Sentinel Lymph Node Biopsy for Breast Cancer

N/A

Recruiting

Led By Andrea Barrio, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Female patients over 18 years of age with biopsy-proven breast cancer

Patients presenting with locally advanced disease in the breast (cT4) and/or in the nodes (cN2/N3) as assessed by clinical exam and imaging

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial is testing how well a sentinel lymph node biopsy can identify residual cancer cells after neoadjuvant chemotherapy in patients with locally advanced breast cancer.

Who is the study for?

This trial is for women over 18 with locally advanced breast cancer who've had neoadjuvant chemotherapy (NAC) and show no remaining cancer in their nodes by physical exam. It's not for those with persistent palpable nodes after NAC, a history of breast cancer on the same side, or if pregnant.Check my eligibility

What is being tested?

The study tests how well the sentinel lymph node biopsy (SLNB) identifies any remaining cancer cells after patients have received NAC for locally advanced breast cancer. The accuracy of SLNB post-chemotherapy is under investigation.See study design

What are the potential side effects?

While specific side effects are not listed here, SLNB procedures may include risks such as infection, bleeding, lymphedema (swelling due to fluid build-up), numbness, or allergic reactions to dyes used during the procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a woman over 18 with confirmed breast cancer.

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My breast cancer has spread to nearby tissues or lymph nodes.

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My cancer nodes responded completely to chemotherapy, as confirmed by a physical exam.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

The false negative rate of sentinel lymph node biopsy in patients with locally advanced breast cancer

Trial Design

1Treatment groups

Experimental Treatment

Group I: Sentinel Lymph Node Biopsy (SLNB)Experimental Treatment1 Intervention

The patients will undergo SLNB with dual tracer mapping using technetium-99m sulfur colloid and isosulfan blue dye, as is standard practice at our institution for cN1 patients. Than the SLNB procedure will be performed

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,936 Previous Clinical Trials

588,748 Total Patients Enrolled

202 Trials studying Breast Cancer

80,953 Patients Enrolled for Breast Cancer

Andrea Barrio, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

1 Previous Clinical Trials

1,250 Total Patients Enrolled

1 Trials studying Breast Cancer

1,250 Patients Enrolled for Breast Cancer

Media Library

Sentinel Lymph Node Biopsy (SLNB) (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT03255577 — N/A

Breast Cancer Research Study Groups: Sentinel Lymph Node Biopsy (SLNB)

Breast Cancer Clinical Trial 2023: Sentinel Lymph Node Biopsy (SLNB) Highlights & Side Effects. Trial Name: NCT03255577 — N/A

Sentinel Lymph Node Biopsy (SLNB) (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03255577 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are volunteers currently being sought out for this experiment?

"According to the information hosted on clinicaltrials.gov, this trial is still actively seeking participants. This research was initially announced in August of 2017 and has had its most recent update as recently as November 2022."

Answered by AI

In what geographical areas is the trial being conducted?

"This experiment is conducted at 8 different clinical sites, located in cities such as Miami, Middletown and New york alongside other locations. To best reduce the demands of journey distance it's important to choose a clinic close by if you decide to join."

Answered by AI

What is the current enrollment size for this clinical trial?

"Affirmative. The clinical trial website lists that this study, which was initially posted on August 17th 2017, is actively recruiting participants. A total of 150 patients need to be recruited from 8 different medical centres."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer

2017. "Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03255577.

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