Hydrochlorothiazide 50mg Tablet for Hypertension

St. David's North Austin Medical Center, Austin, TX
Hypertension+5 More ConditionsHydrochlorothiazide 50mg Tablet - Drug
18 - 50

Study Summary

This trial found that postpartum prophylactic administration of hydrochlorothiazide (HCTZ) may be effective in preventing relapse of preeclampsia or gestational hypertension.

Eligible Conditions
  • Postpartum Pregnancy-Induced Hypertension (PPIH)
  • Superimposed Preeclampsia
  • Pre-eclampsia
  • Pregnancy-Induced Hypertension
  • Postpartum preeclampsia

Treatment Effectiveness

Phase-Based Effectiveness

2 of 3
Phase 3
This is further along than 85% of similar trials

Study Objectives

2 Primary · 6 Secondary · Reporting Duration: 1-6 weeks postpartum

1-6 weeks Postpartum
Adverse Events
1-6 weeks postpartum
Elevation of blood pressure >150/90
Length of hospital stay
Need for additional antihypertensive therapy
Rate of readmission and/or triage visits
Severe composite maternal morbidity
Total Additional doses of anti-hypertensive therapy
Use of resources

Trial Safety

Phase-Based Safety

3 of 3
This is further along than 85% of similar trials

Awards & Highlights

Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 20 Other Conditions
This treatment demonstrated efficacy for 20 other conditions.

Trial Design

2 Treatment Groups

Hydrochlorothiazide 50mg Tablet
1 of 2
Placebo Tablet
1 of 2

Active Control

Non-Treatment Group

612 Total Participants · 2 Treatment Groups

Primary Treatment: Hydrochlorothiazide 50mg Tablet · Has Placebo Group · Phase 3

Placebo Tablet
PlaceboComparator Group · 1 Intervention: Placebo Tablet · Intervention Types: Drug
Hydrochlorothiazide 50mg Tablet
ActiveComparator Group · 1 Intervention: Hydrochlorothiazide 50mg Tablet · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1-6 weeks postpartum

Who is running the clinical trial?

The University of Texas Medical Branch, GalvestonLead Sponsor
228 Previous Clinical Trials
54,370 Total Patients Enrolled
7 Trials studying Hypertension
4,079 Patients Enrolled for Hypertension
Antonio Saad, M.D.Principal InvestigatorUTMB
1 Previous Clinical Trials
3,374 Total Patients Enrolled

Eligibility Criteria

Age 18 - 50 · Female Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

How many patients are enrolled in this research project?

"That is correct. The listing on clinicaltrials.gov confirms that this study, which was first advertised on November 21st 2017, is still recruiting patients. They are looking for 612 people to participate at 3 different locations." - Anonymous Online Contributor

Unverified Answer

What are some of the dangers associated with taking Hydrochlorothiazide 50mg Tablet?

"Hydrochlorothiazide 50mg Tablet is classified as a Phase 3 drug, meaning that there is both efficacy and safety data available. Our team has rated its safety as a 3 out of 3." - Anonymous Online Contributor

Unverified Answer

Are any slots still available for participants in this trial?

"Indeed, the clinical trial is still open and recruiting patients. According to the information on clinicaltrials.gov, the study was first posted on 11/21/2017, with the most recent update being made 8/18/2022. They are looking for 612 participants total, which will be recruited from 3 sites." - Anonymous Online Contributor

Unverified Answer

What is the goal of this clinical trial?

"The primary outcome of this study, which will take place in the 6 weeks post-partum, is the Need for additional antihypertensive therapy. Additionally, we will measure Use of resources (hospital stay, postpartum clinic or emergency room visit within 4-6 weeks of delivery, need for imaging or other invasive procedures), Total Additional doses of anti-hypertensive therapy (addition of total doses that patient received in the postpartum period), and Length of hospital stay (days that patient required to be in-house in the postpartum period) as secondary outcomes." - Anonymous Online Contributor

Unverified Answer

Can I join this clinical trial?

"The ideal candidate for this study is a woman aged 18-50 who has been diagnosed with pre-eclampsia. A total of 612 participants are needed." - Anonymous Online Contributor

Unverified Answer

What are some common reasons why people take Hydrochlorothiazide 50mg Tablets?

"Hydrochlorothiazide 50mg Tablet is often used to counteract sodium retention, but it can also be helpful in managing edema, when other therapies have been ineffective, and for patients who do not respond well to blood pressure medication." - Anonymous Online Contributor

Unverified Answer

Are there other research papers that focus on Hydrochlorothiazide 50mg Tablet?

"There are currently 12 ongoing clinical trials studying the effects of Hydrochlorothiazide 50mg Tablets. 5 of those trials are in their third and final phase. Most of the trial locations for this medication are centred around Kansas City, Kansas; though, there are 80 total locations running these studies." - Anonymous Online Contributor

Unverified Answer

If a septuagenarian meets the other requirements, are they eligible for this research project?

"The parameters for this study only allow patients aged 18 to 50. However, there are 66 other clinical trials for minors and 739 for seniors." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.