Hydrochlorothiazide for Postpartum Hypertension
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing whether hydrochlorothiazide can help prevent or reduce high blood pressure in women who have given birth. The medication works by making you urinate more, which helps lower blood pressure. Hydrochlorothiazide is known for its effectiveness in lowering blood pressure.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are currently on antihypertensive therapy, you may not be eligible to participate.
Is Hydrochlorothiazide safe for postpartum hypertension?
Thiazide diuretics, like Hydrochlorothiazide, may pose a risk to the fetus by affecting blood flow to the placenta, but this is more relevant during pregnancy rather than postpartum. There is no specific safety data for Hydrochlorothiazide in postpartum hypertension, but it is generally used with caution due to potential risks.12345
How does the drug Hydrochlorothiazide differ from other treatments for postpartum hypertension?
Hydrochlorothiazide is a commonly used diuretic (a drug that helps remove excess fluid from the body) for managing high blood pressure, and it is often combined with other medications to enhance its effects. While it is widely used for general hypertension, its specific use for postpartum hypertension is less common, making it a potentially novel option for this condition.678910
What evidence supports the effectiveness of the drug Hydrochlorothiazide for treating postpartum hypertension?
Who Is on the Research Team?
Benjamin Bush, M.D.
Principal Investigator
UTMB
Are You a Good Fit for This Trial?
This trial is for women aged 18-50 who had high blood pressure or preeclampsia during pregnancy. They must not need blood pressure meds at screening, can't be discharged with such meds, and shouldn't have kidney failure, sulfonamide allergy, pre-gestational diabetes, lactose intolerance or issues that prevent follow-up.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Hydrochlorothiazide 50 mg or placebo once daily for fourteen days postpartum
Follow-up
Participants are monitored for safety and effectiveness after treatment, including readmission rates and need for additional antihypertensive therapy
What Are the Treatments Tested in This Trial?
Interventions
- Hydrochlorothiazide
- Placebo Tablet
Hydrochlorothiazide is already approved in United States, European Union, Canada, Japan for the following indications:
- Edema
- Hypertension
- Nephrotic syndrome
- Nephritic syndrome
- Gouty arthritis
- Calcium nephrolithiasis
- Essential hypertension
- Oedema
- Mild to moderate hypertension
- Edema
- Hypertension
- Edema
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Medical Branch, Galveston
Lead Sponsor