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Soft Tissue Augmentation for Immediate Dental Implants

N/A
Waitlist Available
Led By I-Ching Wang, DDS, MS
Research Sponsored by University of Iowa
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adequate tooth space to support an immediate implant placement (i.e., adequate mesiodistal space of greater than or equal to 6 mm and interocclusal space to support a non-occluding provisionalization).
Adequate tooth space to support an immediate implant placement (i.e., adequate mesiodistal space of greater than or equal to 6 mm and interocclusal space to support a non-occluding provisionalization)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement)
Awards & highlights

Study Summary

This trialwill compare the effectiveness of different treatments for restoring the gum and bone around immediate implants, which are used to replace missing teeth.

Who is the study for?
This trial is for adults aged 18-95 with a single tooth needing replacement in the upper front area, who maintain good oral hygiene and have adequate bone support for an implant. Smokers, pregnant individuals, those with certain medical conditions or treatments affecting bone health or healing are excluded.Check my eligibility
What is being tested?
The study tests how well two different grafting techniques (CTG and VCMX) prevent gum and bone changes around new dental implants compared to no augmentation. It uses ultrasound imaging to monitor these changes over time.See study design
What are the potential side effects?
Potential side effects may include discomfort at the graft site, swelling, bruising, bleeding or infection. The CTG procedure might also cause additional pain where tissue was taken from.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have enough space in my mouth for an immediate dental implant.
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I have enough space in my mouth for an immediate dental implant.
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I am between 18 and 95 years old.
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I have one bad tooth in the front upper part of my mouth.
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My tooth socket's outer wall bone loss is 3mm or less.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement)
This trial's timeline: 3 weeks for screening, Varies for treatment, and multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in from Baseline in Soft and Hard Tissue Thickness as assessed by ultrasound

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Xenogeneic Volume-Stable Collagen Matrix (VCMX) graftExperimental Treatment1 Intervention
Subjects in this arm will have Xenogeneic Volume-Stable Collagen Matrix (VCMX) graft at the time of immediate implant placement.
Group II: Tuberosity Connective Tissue Graft (CTG)Experimental Treatment1 Intervention
Subjects in this arm will have a tuberosity connective tissue graft at the time of immediate implant placement.
Group III: No Soft Tissue AugmentationActive Control1 Intervention
Subjects in this arm will have no soft tissue augmentation at the time of immediate implant placement.

Find a Location

Who is running the clinical trial?

University of IowaLead Sponsor
446 Previous Clinical Trials
879,462 Total Patients Enrolled
I-Ching Wang, DDS, MSPrincipal InvestigatorUniversity of Iowa

Media Library

No Soft Tissue Augmentation Clinical Trial Eligibility Overview. Trial Name: NCT05330702 — N/A
Immediate Implant Placement Research Study Groups: Tuberosity Connective Tissue Graft (CTG), Xenogeneic Volume-Stable Collagen Matrix (VCMX) graft, No Soft Tissue Augmentation
Immediate Implant Placement Clinical Trial 2023: No Soft Tissue Augmentation Highlights & Side Effects. Trial Name: NCT05330702 — N/A
No Soft Tissue Augmentation 2023 Treatment Timeline for Medical Study. Trial Name: NCT05330702 — N/A
Immediate Implant Placement Patient Testimony for trial: Trial Name: NCT05330702 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment still open for participation in this experiment?

"The data found on clinicaltrials.gov shows that this trial, which began recruiting patients on November 1st 2022, is no longer actively enrolling participants. However there are 8 other trials in the same field currently accruing individuals for their studies."

Answered by AI

Do the age requirements for this trial permit individuals above 18 years old to participate?

"In accordance with the trial's eligibility criteria, potential participants must be aged 18 or over and 95 or younger."

Answered by AI

Is there an opportunity to register for this research project?

"This clinical trial is enrolling 40 candidates aged between 18 and 95 for the purpose of tooth extraction. In order to join, applicants must have a single unviable molar in the aesthetic zone #5-#13 with adequate oral hygiene (FMBS/FMPS <25%), sufficient space to support immediate implantation (>6 mm mesiodistal and non-occluding provisionalization), as well as ≤3mm postextraction vertical bone defect on the buccal socket wall."

Answered by AI

Who else is applying?

What state do they live in?
Nevada
North Carolina
Texas
What site did they apply to?
University of Iowa College of Dentistry and Dental Clinics
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
3+
0

Why did patients apply to this trial?

My missing teeth and with research like this, I can help with the studies and get implants at the same time.
PatientReceived 1 prior treatment
All my teeth are falling out and I really need to get them fixed I really can’t afford it so I thought I’d give you a try.
PatientReceived no prior treatments
I am healthy 62 year old still working and very active. I have been delaying the removal of a couple teeth in order to not lose.
PatientReceived no prior treatments
Hoping that I could get some help on implants. My gums hurt when I eat due to the food. I’m losing weight because I can only eat soft foods.
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation
I-Ching Wang 2023. "Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05330702.
~18 spots leftby May 2025
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